사상체질과 두피상태의 상관관계에 대한 연구보고

노석선,이태현,황성록,유인기,이인호,강상진,류현신,Roh, Seok-Seon,Lee, Tae-Hyun,Hwang, Seong-Lok,Yoo, In-Kee,Lee, In-Ho,Kang, Sang-Jin,Ryu, Hyun-Shin 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objectives ; Sasang Constitional Medicine is a part of Korean traditional Medicine, and classify human constitution into four types. Scalp and hair is a part of skin. Skin is one of constitutional charasteristic element. So we researched a correlation between Sasang constitutions and Korean adult scalp and hair condition. This is a basic study to find constitution can be a important factor to care scalp and hair. Methods ; We examined Sasang constitutions and scalp and hair condition of 80 human who aged from 20-50. Scalp disease, dandruff was observed by video micro scope and sebum tape diagnosis. Thickness of hair was measured by Laser Scan Micrometer(LSM-3100). Itching sense and life habit was also investigated. Constitution diagnosis and scalp, hair diagnosis was investigated seperately as a blind test and the data was statistically analyzed with chi-square test, correlation analysis, one-way analysis of varience. Results ; 1. In Sasang Constitution, Taeumin group had significant tendency of oilily scalp. 70% of Taeumin group had oilily scalp. 2. The group of dry or oilily scalp had more itching sense and more sensativity of scalp compaired to neuter scalp group. 3. There was no correlation between height, weight, thickness of hair, itching sense, scalp disease and Sasang constitution. 4. There was correlation between loss of hair and drinking alcohol, obesity, curly hair, soft scalp. Conclusions ; Korean adult scalp and hair condition had correlation with Sasang constitution.

봉선화 내에 함유 된 레톡시나프타퀴논의 미백활성에 미치는 영향

노석선 ( Seok Seon Roh ),황동성 ( Dong Sung Hwang ) 대전대학교 한의학연구소 2012 한의학연구소 논문집 Vol.21 No.1

加味托里消毒飮이 瘡傷 治癒에 미치는 影響

서형식,노석선,Seo, Hyung-Sik,Roh, Seok-Seon 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.2

In order to investigate the effects of GamiTakliSodocyum(GTS) on wound healing, migration of epidermis, formation of granulation tissue and number of capillary within the granulation tissue were measured in diabetic mice by local application and NZW rabbits by local application and prescription of medicine in vivo, and proliferation of human epidermal keratinocytes and human dermal fibroblasts and composition of extracellular matrix were measured in vitro. The results were summerized as follows. 1. $2\%,\;10\%$ GTS remarkably increased migration of epidermis in diabetic mice by local application. 2. $2\%,\;10\%$ GTS remarkably increased formation of granulation tissue, number of neovascularization within the granulation tissue in diabetic mice by local application. 3. 5\%,\;10\%$ GTS remarkably increased migration of epidermis in NZW rabbits by local application. 4. $5\%,\;10\%$ GTS remarkably increased fonnation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by local application. 5. $5\%,\;10\%$ GTS increased migration of epidennis in NZW rabbits by prescription of medicine. 6. $5\%,\;10\%$ GTS increased formation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by prescription of medicine. 7. GTS didn't show effect on the proliferation of human epidermal keratinocytes. 8. GTS increased the proliferation of cultured human dermal fibroblasts. 9. GTS increased the expression of procoliagen ${\alpha}1(I) mRNA in cultured human dermal fibroblasts. 10. GTS increased the expression of fibronectin mRNA in cultured human dennal fibroblasts according to dosage of GTS using northern blot hybridization but didn't increase, using RT-PCR. From the above results, it is conclude that GTS might use on wound healing.

$Henoch-Sch{\ddot{o}}lein$ Purpura 환자 치험 2례

연경진,노석선,김창훈,Yeon, Kyoung-Jin,Roh, Seok-Seon,Kim, Chang-Hun 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

The Henoch-Schnlein Purpura (HSP) is a systemic small vasculitis, characterized by palpable purpura, abdominal pain, hematuria or proteinuria, and arthritis. The etiology is unknown but it is manifested by allergic reaction, so it is called Anaphylactoid Purpura. The prognosis of disease is usually good, but about 50% of patients have experienced recurrences. Oral corticosteroid is treatment of choice, but it cannot prevent recurrence of Disease. We experienced two case of young patients who suffered from the Henoch-Schnlein purpura. We prescripted Mokyangbinrang-hwan, Insamyang-witang, Gwibi-tang. For both two patient, symptoms were much relieved.

원예내장에 관한 문헌적 고찰

류현신,노석선,Rheu Hyun-sin,Roh Seok-seon 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.2

The Wonyenaejang is equivalent to the (senile)cataract in western medicine. The word cataract is used to describe the natural lens that has turned cloudy. As the natural lens of the eye becomes cloudy, it does not allow light to pass through it. Cataracts usually start as a slight cloudiness that progressively grows more opaque. As the cataract becomes more mature(increasingly opaque and dense), the retina receives less and less light. The light that does reach the retina becomes increasingly blurred and distorted. This causes gradual impairment of vision. If left untreated, cataracts can cause needless blindness. Although there are many kinds of cataracts, a senile cataract is the most common one. We chose the oriental medicine textbooks and the oriental medicine journals that were dealing with the symptoms, etiology, and internal/external treatments. The results were as follows : 1. The main causes of this disease are weak liver and kidney, burning up of the wind and heat in the liver and gall, weak spleen and stomach. 2. As the internal treatment of the Cataract, Geegukjihwangtang is mostly prescribed. 3. As the external treatment of the Cataract, (l) In the field of medicine for external application is commonly prescribed (2) In the field of drug action, frequently used treatments are as follows. emission of the evil, alleviation of fever, removal of lump of blood, and the medicine for external applications. (3) In the field of four Qi, cold medicine is commonly prescribed. (4) In the field of five tastes, bitter/hot/sweet mdicine are commonly prescribed. (5) In the field of toxicity, non-togic medicine is commonly prescribed. (6) In the field of channel distribution, most of the medicine belong to liver channel.

淸上防風湯加味이 面포에 미치는 影響

홍석훈,노석선,Hong, Seok-Hoon,Roh, Seok-Seon 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.1

This study was carried out to prove the effects of CBTLC on the $5{\alpha}$-reductase inhibition, the sterilizing power for Propionibactrium acnes, the cytotoxicity of human monocyte, the inhibition for prosta-glandins($PGE_2$), Interleukins(IL-$1{\beta}$) and TNF-${\alpha}$ in inflammation, and the size of Hamster ear sebaceous gland concerned with Acnes. The result were obtained as follows : 1. On the $5{\alpha}$-reductase inhibition of CBTLC in vitro, An undiluted solution of CBTLC was $71{\%}$ inhibition on $5{\alpha}$-reductase and $\frac{1}{10}$ diluted solution of CBTLC was $20{\%}$ inhibition on $5{\alpha}$-reductase. 2. On the sterilizing power for Propionibactrium acnes concerned in Acnes, an undiluted solution and $\frac{1}{10}$ diluted solution of CBTLC formed 12mm clear zone diameters. 3. CBTLC was showed the cytotoxicity of human monocyte in $0.08{\%}$ and $0.12{\%}$ of CBTLC. 4. $0.01{\%}$ and $0.04{\%}$ of CBTLC inhibited the production of prostaglandins($PGE_2$) in the human monocyte stimulated with P. acnes LPS. 5. $0.08{\%}$ and downward of GMHBS inhibited the production of interleukins(lL-$1{\beta}$) in the human monocyte stimulated with P. acnes LPS. 6. $0.08{\%}$ and $0.12{\%}$ of GMHBS inhihited the production of TNF-${\alpha}$ in the human monocyte stimulated with P. acnes LPS. 7. As the antiandrogenic compound, CBTLC was used in hamster ears with topical application. CBTLC was diminished slightly on the size of hamster ears sebaceous gland.

乾癬에 活用되는 加味當歸飮子에 對한 實驗的 硏究

이건학,노석선,Lee, Keun-hak,Roh, Seok-seon 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1

The purpose of this research was to investigate the effect of Kamidangkwieumja(KDEJ) water extract on the allergy reaction in mice. The results were obtained as follows: 1. The passive cutaneous anaphylaxis induced by egg albumin in fat was not affected. 2. The lethal anaphylaxis induced by platelet activating factor in mice. was inhibited. 3. The degranulation of peritoneal mast cells induced by compound 48/80 was not affected. 4. The acute hind paw edema was inhibited after 2hours later when it was induced by histamine. 5. The permeability of evans blue into peritoneal cavity induced by acetic acid was not affected. 6. Arthus reaction in mice was not affected. 7. The delayed type hypersensitivity induced by SRBC was inhibited. 8. The contact dermatitis induced by DNFB was not affected. 9. The hemagglutination titer induced by SRBC was inhibited. 10. The writhing syndrome induced by acetic acid was inhibited. 11. The population of heper T cells in mice thymus was enhanced. 12. The phagocytic activity of peritoneal macrophages was enhanced. 13. The production of nitric oxide from peritoneal macrophages was not affected. These results suggest that the anti-allergy effect of KDEJ is caused by steroidlike and enhanced immune action. The steroidlike action of KDEJ correspond with steroid-applying-method that frequently used in clinic, so it is used io treatment of psoriasis. The research on anti-allergy of KDEJ might has to be continued.

內托千金散加味方이 3-MCA로 誘發된 皮膚癌 및 免疫調節作用에 미치는 影響

김희택,노석선,Kim, Hee-taek,Roh, Seok-seon 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.2

In order to investigate the effect of Naetakchungumsankamibang(NTCGS) water extract on the skin tumor induced by 3-MCA and immunological responses in mice, the cytotoxicity against SK-MEL-2 cells and total number of tumors induced by 3-MCA were measured. The numbers of WBC, platelets and RBC, plaque forming cells, hemagglutinin titer, hemolysis titer, carbon clearance, proliferation of splenocyte by thymidine uptake assay, splenic leukocyte by FACS analysis and $TNF-{\alpha}$ were also measured for the evaluation of the immunological responses. The results were obtained as follows: 1. In cytotoxicity against SK-MEL-2 cells, concentration inhibiting cell growth up to below $20\%$ of control was recognized at 1mg/ml of NTCGS. 2. In Inhibitory effect on the skin tumor induced by 3-MCA, the results showed a strong inhibitory effect of NTCGS. 3. In hematological changes in the tumor bearing mice, the numbers of WBC decreased significantly in NTCGS treated group as compared with control. 4. In hematological changes in the tumor bearing mice, the numbers of platelets increased significantly in NTCGS treated group as compared with control. 5. In hematological changes in the tumor bearing mice, the numbers of RBC increased with no significance in NTCGS treated group as compared with control. 6. Effects of the plaque forming cells in the tumor bearing mice, NTCGS treated group exhibited a significant effect compared with control. 7. In terms of the effects on hemagglutinin titer, NTCGS treated group showed higher level than control, without significance. 8. In terms of the effects on hemolysis titer, NTCGS treated group showed higher level than control, without significance. 9. In terms of the effects on phagocytic index K in Balb/C mice, NTCGS treated group showed significant difference from control. 10. In terms of the effects on proliferation of splenocyte by thymidine uptake assay, NTCGS showed significant effect at the concentration of 0.5mg/ml. 11. In terms of the effects on splenic leukocyte of Balb/C mice by FACS analysis, NTCGS treated group showed significantly higher level of helper T cell, B cell and macrophage than in control. 12. In terms of the effects on the secretion of $TNF-{\alpha}$, the treated group showed significant effect at the concentration of 1mg/ml of NTCGS. Based on the results summarized above, NTCGS is considered to have antitumor activity and immunological responses against skin tumor, and to be usable fur the treatment.

回春凉膈散과 龍石散이 抗炎作用에 미치는 影響

강승원,노석선,Kang, Shung-won,Roh, Seok-seon 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1

Hoichunyonggyuksan(HCYGS) and Yongseksan(YSS) are important prescriptions that have been used in oriental medicine for stomatitis and wound healing. The study was done to evaluate the inhibitory effects of cytotoxicity, formation of superoxide on the macrophage and neutrophil, prostaglandins($PGE_2$), interleukins($IL-1{\Beta}$), collagenase activity and synthesis of collagen and DNA. The results were obtained as fo1lows: 1. HCYGS and YSS were not showed the proliferation difference of human fibroblast and monocyte in all concentrations to be experimented and in result, it was concluded that they have no cytotoxicity. 2. YSS inhibited the formation of superoxide to $48\% at the concentration of $0.001\%$ in the mouse monocyte. 3. HCYGS inhibited the formation of superoxide to $13\%$ at the concentration of $0.001\%$ as compared with control in the human monocyte. 4. HCYGS and YSS inhibited the formation of superoxide to $25\%\;and\;35\%$ respectively at the concentration of $0.0001\%\;and\;HCYGS\;showed\;38\%$ inhihitory rate on the formation of superoxide at concentration of $0.001\%$ in the human neutrophil. 5. The concentration of inhibiting the production of prostaglandins($PGE_2$) to $11\%$ in the human monocyte stimulated with E. coli were $0.01\%$ of HCYGS. 6. The concentration of inhibiting the production of interleukins($IL-l{\Beta}$) to $43\%\;and\;39\%$ in the human monocyte stimulated with E. coli were $0.01\%$ of HCYGS and YSS. 7. HCYGS and YSS didn't influence on collagen synthesis and total protein in fibroblasts. 8. HCYGS and YSS inhibited the collagenase activity to $22\%\;and\;19\%\;at\;0.1\%,\;45\%\;and\;56\%\;at\;0.2\%,\;57\%\;and\;52\%$ at $0.5\%$ respectively, but YSS exerted the inhibitory effect on collagenase activity to $27\%$ at the lower concentration of $0.01\%$. 9. HCYGS and YSS didn't show the faster recovary than control group hut exerted the consistant effect on the anti-inflammations and the formation of granulation tissue.

敷貼藥의 活用에 관한 硏究

서형식,노석선,Seo, Hyung-Sik,Roh, Seok-Seon 대한한방안이비인후피부과학회 2000 한방안이비인후피부과학회지 Vol.13 No.2

The result were as follows: 1. Apply the drug to the affected part can used every time of ulcer. 2. Apply the drug to the affected part is used cold drug on yang-syndrome, hot drug on yin-syndrome, regulate drug on ban yin and ban yang-syndrome. 3. Apply the drug to the affected part is used alcohol, water, allii radix(인), zingiberis rhizoma recens(姜), juice of chrysanthemi flos(菊花) and so forth. 4. Apply the drug to the affected part can't used hot drug on yang-syndrome, cold drug on yin-syndrome. 5. Apply the drug to the affected part is used to be very busy of YouYuiKimHoangSan(如意金黃散). 6. Apply the drug to the affected part is used to be very busy on the angelicae adhuricae radix(白芷) of disperse the edema and drain the pus, and on the arisaematis rhizoma(南星), rhei radix et rhizoma(大黃), olibanum(乳香), phellodendri cortex(黃柏), calomelas(輕粉), glycyrrhizae radix(甘草), angelicae gigantis radix(當歸), myrrha(沒藥) of clearing away heat, activating blood circulation and relieve pain. 7. Apply the drug to the affected part is clearing away heat, activating blood circulation 8. Apply the drug to the affected part is cold and hot. 9. Apply the drug to the affected part is pungent, bitter and sweet. 10. Apply the drug to the affected part is non-toxic. 11. Apply the drug to the affected part is used to be very busy on the chanel of liver, heart, spleen, lung, stomach.