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Oxidant에 의한 신장세뇨관 물질이동계의 장애에 대한 단삼(丹參)의 효과
김상범,정지천,Kim, Sang-Beum,Jeong, Ji-Cheon 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.1
This study was undertaken to determine whether Salviae-radix (SVR) exraction exerts benefical effect against oxidant-induced inhibition of tetraethylammonium (TEA) uptake which is actively secreted by renal proximal tubules. TEA uptake increased as function of incubation time to 60 min. When renal cortical slices were exposed to 50 mM $H_2O_2$, TEA uptake was significantly inhibited. The inhibition was significantly protected by addition of 0.5% SVR extraction. The benefical effect of SVR was dose-dependent over the concentration range of 0.1-1%; $H_2O_2$ (50 mM)-induced inhibition of TEA uptake was completely protected by 0.5-1% SVR extraction. $H_2O_2$ increased LDH release which was accompanied by an increase in lipid peroxidation in renal cortical slices. These changes were prevented by 0.5% SVR. These results suggest that SVR exerts benefical effect against oxidant-induced impairment of membrane transport function, this effect may be due to by an antioxidant action.
노재현 ( Rho Jae-hyun ),최영현 ( Choi Yung-hyun ),김상범 ( Kim Sang-beum ) 한국전통조경학회(구 한국정원학회) 2018 한국전통조경학회지 Vol.36 No.3
조선시대 설정된 구곡의 현황과 그 실태를 파악하기 위한 기초적 단계로서 남한 지역에 분포하는 구곡원림의 분포현황과 설정된 구곡의 경물 특성을 파악한 본 연구의 결론은 다음과 같다. 첫째, 국내에 분포하는 구곡원림은 대경권에 55개소(51.4%), 충청북도에 22개소(20.56%)가 집중 분포하는 것으로 확인되었다. 구곡이 집중 분포된 곳은 소백산-월악산-속리산을 잇는 백두대간상의 좌우안과 낙동정맥 우안의 낙동강 유역에 집중되는 경향이 매우 강하게 나타났는데, 이는 영남 성리학파의 학풍과 그들의 원림 향유와 밀접하게 관련된 것으로 판단된다. 둘째, 기초지자체별로 구곡의 분포를 살펴 본 결과, ‘한국 정신문화의 수도’로 자타가 공인하는 안동시에 10개소(9.35%)로 가장 많은 구곡원림이 존재하는 것으로 확인되었고, 다음으로 괴산군 9개소(8.41%), 문경시 8개소(7.48%), 봉화군 6개소(5.61%), 영주시 5개소(4.67%) 등의 순으로 나타났다. 셋째, 구곡원림의 설정 시기는 18C 33개소(33.0%)를 필두로, 19C 33개소(33.0%), 20C 14개소, 17C 13개소, 16C년 4개소 등의 순으로 16세기 이후부터 조선 말기까지 꾸준히 구곡문화가 전파된 것으로 파악되었다. 특히 조선 후기인 18~19C(66.0%) 사이에 높은 빈도로 구곡원림이 설정된 것으로 나타났다. 넷째, 곡의 집경형태는 ‘구곡’이 97개소(90.65%)로 압도적이었으며 그 중 상향식 구곡은 총 99개소(92.5%), 하향식 구곡은 총 8개소(7.5%) 구곡으로 확인되었다. 다섯째, 구곡 콘텐츠 중 구곡시는 67개소(64.49%)로 가장 많이 나타났고 바위 글씨가 29개소(27.10%), 구곡도는 16개소(14.95%)가 존재하는 것으로 확인되었다. 여섯째, 구곡 경관구성에 가장 많이 등장한 경물은 대(臺)가 124개(13.05%)로 월등히 많았는바, 이는 조선구곡의 특성을 부각하는 경물 속성으로 볼 수 있다. 이어 암(岩)을 포함한 암(巖)이 115개(11.2%), 담(潭) 73개(7.68%), 정(亭) 48개(5.05%), 동(洞) 39개(4.10%), 산(山) 36개(3.78%), 봉(峯) 27개(2.84%), 연(淵) 23개(2.42%), 천(川)·탄(灘) 각각 22개(2.31%) 등의 순으로 나타났다. 향후 구곡의 총 연장거리 및 경사도 등 지형 등을 감안한 구곡의 입지유형 분류 등의 연구가 뒤따라야 진정한 구곡 원림의 경물 특성 및 입지분포 특성이 더욱 명료하게 부각될 것으로 예상된다. This study was attempted to understand present status and characteristics of landscape components of the domestic Korean Gugokwonlim created by the classical scholars in the Joseon Dynasty. The results are as follows. First, Distribution of Gukokwonlim in Korea shows that 55(51.4%) are located in Daegu and Gyeongsangbuk-do, and 22(20.56%) are located in Chungcheongbuk-do. Concentrated locations of Gugok are on the part of Baekdudaegan, from Sobaeksan mountain to Sokrisan mountain via Wolaksan mountain, and the Nakdong River basin of the Nakdong vein in the right bank. This consideration seems to be closely related to the academy of Yeongnam Confucianism and the their trend of Wonrim enjoyment. Second, according to the result of examining the distribution of Gugok according to the basic local government authority, The biggest number of the Gugok places(10 places, 9.35%) are located in Andong, which is called 'the capital of Korean spiritual culture.' Additionally in order, 9 places(9.45%) is located in Goesan, 8 places(7.48%) in Mungyung, 6 places(5.61%) in Bonghwa, and 5 places(4.67%) in Yeongju. Third, in order to the creating time of Gugokwonlim, 33 (33.0%) were created in 18<sup>th</sup> century, and other 33 (33.0%) were created in 19<sup>th</sup> century. In addition, 14 were created during 20<sup>th</sup> century, while 13 were created in 17<sup>th</sup> century. And 4 were created in 16<sup>th</sup> century. Respectively. great number of 18<sup>th</sup> and 19<sup>th</sup> centuries shows that many(66.0%) Gugokwonrim were created between late 18th to 19th centuries. Fourth, There were 97(90.65%) of 'Gugok' in the form of collecting type, and a total number of bottom-up style Gugok were 99(92.5%) while top-down style Gugok were 8(7.5%). Fifth, Among the contents of Gugok, 67 were found in pome of Gugok(64.49%), 29 caved letters in rock(27.10%), and 16 in painting of Gugok(14.95%). Sixth, The most emerged landscape components of Gugok was Dae(臺) 124(13.05%), followed by Am(巖) 115[11.2%, including of Am(岩)] 115(11.2%), and Dam(潭) 73(7.68%), Jeong(亭) 48(5.05%), Dong(洞) 39(4.10%), San(山) 36(3.78%), Am(岩, rocks) 31(3.26 %), Bong(峯, peaks) 27(2.84%), Yeon(淵) 23(2.42%) and Chun(川) and Tan(灘) 22(2.31%). Mostly, common landscape components of Gugok are entrusted natural things. It is expected that more studies about the analysis of characteristics of Gugok’s positioning types considering total distance and a gradient are required to understand more clearly characteristics and location distribution of true Gugok and its landscape components.