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寒冷과 溫熱刺戟을 받은 흰쥐의 體溫과 血淸反應에 對한 實驗的 硏究
朴元煥,崔達永 대한동의병리학회 1989 동의생리병리학회지 Vol.4 No.-
This study was planned to observed the reaction of temperature-variation occurring in a living body received cold stimulus and heat stimulus. The external condition was devised to measure Han-Yol (cold and heart) reaction. According to the type of stimulus-method(cold and heat) rats were divided two groups (C-1ㆍC-2 and H-1ㆍH-1) The change of rectal temperature and transaminase, glucose, alkaline phosphatase, total protein, albumin in blood serum were measured 0, 1, 2, 4, 6 and 8 hours after one hour exposure to cold or heat (C-1, H-1) and immediately after one cold or heat, the stimulus being 1, 2, 3, 5 and 7 hours (C-2, H-2) Their results were as follows : 1) In the rectal temperature, old-stimulus-group showed higher degree compared with heat-stimulus-group. (C-2) group showed higher significance than (C-1) group, and also. (H-1) group showed higher significance than that of (H-1) group. 2) In serm glutamic oxaloacetic transaminase activities, (C-2ㆍH-2) group showed higher significance than (C-1ㆍH-1) group, also (H-1) group showed higher significance than (C-1) group particulary, (C-2ㆍH-2) group showed an especially higher value at 3, 5 hours' stimulus group. serum glutamic pyruvic transaminase activities showed an especially higher value at 2 hour' stimulus of (C-2) group. 3) In variation of glucose level, (H-1) group showed rapidly higher value than (C-1) group, (H-2) group showed an especially higher value at 1 hour' stimulus group. 4) In alkaline phosphate activities, (C-1) group showed an especially higher value at 1 hour' stimulus group, (C-2) group showed rapidly higher significance than (H-2) group. 5) In total protein, (H-1) group (at 0, 1, 6 hours' stimulus) showed higher significance than (C-1) group, (C-2ㆍH-2) group decreased gradually as extension of stimulus hours. 6) In albumin, (C-1) group showed a statistical significance at 8 hours' stimulus, (H-2) group showed higher significance than (C-2) group. Han-Yol(cold and heat) stimulus caused metabolic abnormal stimulation and depression in the body, and the reaction of Han-Yol (cold and heat) stimulus caused relatively variation as resisting power in the body. But, in order to make an indication of Han-Yol (cold and heat) stimulus, continuous study is more necessary.
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健脾益氣湯 및 加菱實方의 cyclophosphamide에 依한 副作用 抑制에 關한 實驗的 硏究
崔達永,金俊錡,구입본,朴元煥 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1
韓醫學에 있어서 癌의 治療에 대해서는 韓藥을 利用한 抗癌劑의 開發과 아울러 東·西醫學의 結合을 통한 治療 效果의 增大 方向에서 化學療法과 放射線療法의 副作用을 減少시키는 藥劑 및 處方에 대한 硏究가 활발히 진행되어 왔다. 근래 毆陽汝忠은 항암제 부작용 감소를 위한 치법으로 健脾益氣法, 和胃降逆法, 補益氣血法, 調陽肝腎法 등을 제시하였는데, 健脾益氣湯은 이러한 치법에 의거하여 四君子湯에 益氣의 황기, 陳皮와 補心의 速志, 酸棗仁을 가미하여 創方된 것으로 臨床事例分析을 통하여 항암제 부작용으로 인한 胃腸障碍, 骨髓抑制,肝腎障碍, 神經損傷을 개선한다고 보고되었으며, 菱實은 韓國과 中國, 日本 등에서 胃癌이나 胎毒, 酒毒에 使用되고 있다. 이에 著者는 健脾益氣湯 및 加菱實方의 抗癌劑 副作用에 대한 抑制 效果를 實驗的으로 立證하기 위하여 흰쥐에 化學療法劑인 cyclophosphamide를 注射하여 副作用을 誘發시키고, cyclophosphamide 投與 前後 各 5日間 健脾益氣法湯 및 加菱實方을 投與한 다음 GOT, GPT, BUN, creatinine, 白血球數, 赤血球數, 血小板數를 測定하였으며, 腹腔癌을 誘發시킨 雄性 생쥐에 健脾益氣湯 및 加菱實方 投與 5日後 cyclophoshamide를 注射하여 副作用을 誘發시키고 白血球數, 赤血球數, 血小板數를 測定하였다. 健脾益氣湯 및 加菱實方은 cyclophoshamide의 副作用에 대한 抑制 效果가 있는 것으로 사료되어 동서의학의 결합을 통하여 암치료에 유효하게 응용될 수 있을 것으로 기대된다. In order to investigate the effects of Gunbiikgitang and Gunbiikgtangganungsil on reducing side-effects of cyclophosphamide to the rats, and mice which have abdominal tumor after Sarcoma-180 cells were transplanted, cyclophosphomide, the anti-cancer agent, was injected in order to induce the side-effects, and the extract of Gunbiikgitang and Gunbiikgtangganungsil was administrated through mouth from 5 days before the injection to 5 days after the injection, and observe GOT, GPT, BUN, creatine, number of leukocyte, erythrocyte an thrombocyte. The results are summarized as follows: 1. In the effects of the inhibition of side-effects on the liver function, the GOT activity were proved to be reduced by the Gunbiikgitang and Gunbiikgtangganungsil and GPT activity were proved to be reduced by the Gunbiikgitang. 2. In the effects of the inhibition effect on the side-effects on the kidney function, the BUN and creatine remained unchanged in all groups. 3. In the number of leukocyte, erythrocyte and thrombocyte, the sample groups of Gunbiikgitang and Gunbiikgtangganungsil that did not had cancer showed an increase compared with control group. 4. In the number of erythrocyte and thrombocyte, the sample group of Gunbiikgitang and Gunbiikgtangganungsil that had cancer showed an increase compared with control group. while, there was no distinguishable development in the study on the cancer-carrier mice in the number of leukocyte. As the result of above experiment, it is presumed that Gunbiikgitang and Gunbiikgtangganungsil has proven to have inhibitory effect on side-effects of cyclophospnhomide. We can conclude that Gunbiikgitang and Gunbiikgtangganungsil will be useful for cure of the cancer in occidental and oriental medical world.
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文濬典,崔達永,朴元煥,尹相柱 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-
연구배경 : 최근 우리나라에 있어서도 생활 양식의 서구화로 말미암아 다발하고 있는 각종 현대병의 하나인 고지혈증을 한의학적으로 치료하기 위한 방법론의 개발을 연구목적으로 하여, 한의학의 전통적 병인 개념인 담음이론을 통해 고지혈증의 한의학적 개념을 설명하고, 〈의학입문〉처방인 소조중탕을 통해 치료 약재의 개발 가능성을 실험적으로 규명하고자 한다. 방법 : 실험동물에 cholesterol현탁액을 투여하여 고지혈증을 유발시키면서, 〈의학입문〉에 수재된 소조중탕을 투여하여 혈청지질에 포함되어 있는 total-cholesterol, H. D. L-cholesterol, triglyceride, phospholipid 등의 함량변화를 관찰한다. 결과 : 血淸中 total-cholesterol과 triglyceride含量에 미치는 影響은 對照群에 比하여 매우 顯著한 有意性있는 減少가 나타났으며, 血淸中 H.D.L.-cholesterol과 phospholipid含量에 미치는 影響은 對照群에 比하여 有意性있는 減少가 나타났으며, 血淸中 total cholesterol과 HDL cholesterol의 比率은 對照群에 比하여 有意性이 認定되지 않지만 total cholesterol과 phospholipid의 比率은 對照群에 比하여 有意性이 認定된다. 결론 : 祛痰之劑인 小調中湯은 高脂血症의 改善에 有意性있는 成績을 나타내므로 高脂血症과 痰飮은 相關性이 있으며 脂質代謝異常에 따른 動脈硬化症에도 活用될 수 있는 것으로 思慮된다. In order to study the effects of Xiaotiaozhongtang on hyperlipidemia, white rats were induced by lipid metabolism disorder by the oral-injection of cholesterol. The effects of Xiaotiaozhongtang on lipid in serum were measured by the quantity of total-cholesterol and of H.D.L-cholesterol and of triglyceride and of phospholipid, by the rate of total-cholesterol vs H.D.L-cholesterol and of total-cholesterol vs phospholipid in serum. As a result, we can conclude as follows: 1. Effects of Xiaotiaozhongtang on total-cholesterol and triglyceride levels in serum of cholesterol treated rats were very noticeable. 2. Effects of Xiaotiaozhongtang on H. D. L-cholesterol and phospholipid levels in serum of cholesterol treated rats were noticeable. 3. Effect of Xiaotiaozhogtang on the rate of total-cholesterol vs H. D. L-cholesterol in serum of cholesterol treated rats was unnoticed, but on the rate of total-cholesterol vs phospholipid was noticeable. Thus,as the above-mentioned, on hyperlipidemia, the effects of Xiaotiaozhongtang can be recognized. Secondly, both hyperlipidemia and "phlegm-retention" have correlation each other. In the last place,Xiaotiaozhongtang may be used to artherosclerosis induced by, lipid metabolism disorder, hyperlipidemia.
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