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구재희,남철현,최연희,배향선,신옥순,양숙희,이명옥 慶山大學校 保健福祉硏究所 2002 保健福祉硏究 Vol.7 No.-
This study was conducted to analyze aspects of women's skin care and related factors in order to contribute to community residents's right skin care. The subjects of this study was 800 women who were 15 to 65 years old. Data were collected in Daegu City and Kyungsan City from June 21, 2002 to August 18, 2002. The results of this study can be summarized as follows. 1. According to socio-demographic characteristics of the respondents, 26.8% of them were in twenties. 50.9% of them was students at colleges or graduated from collges. 38.3% was students and 37.5% was housewives. 55.5% belonged to the middle economic class. 2. 47.9% of the respondents replied that they were in good health. 57.2% of them had fair skin, while 25.1% had dark skin. According to health condition of face skin, 61.5% was in regular condition, while 26.0% was in bad condition. 29.9% had drying face skin and 21.3% had neutral or complex character of face skin. 3. Among the reasons they had trouble with face skin, the proportion of having the rough skin was highest (25.0%). 16.6% replied that they had trouble with a lot of wrinkles and 16.3% replied that they had trouble with dark face skin. 25.4% responded that their face skin was too tight. 13.3% replied that they had trouble with scars. 4. The factors significantly influencing the experience of skin care were age, education level, residence, experience of side effect of cosmetics, experience of skin diseases on face or body, experience of trouble after receiving skin care, and experience of trouble with acne. From above results, it can be concluded that selection of proper skin care rooms is important in receiving desirable skin care and preventing side effect related to skin care. The women also must be cautious in selecting and using cosmetics and massage pack. The government, related organizations, and skin and beauty specialists must make efforts to develop education programs for healthy skin care.
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황구연,최민수,정연숙 진주교육대학교 1990 論文集 Vol.34 No.1
The learning activities of young children have been frequently accomplished through the prose materials varied in the form and the structure. The probe passages mean the language activities that explain, describe, and tell about the objects and events in several sentences. It is needed the concrete materials and the method of instruction in order that young children understand the abstract and complex informations and concepts in prose. The materials of instruction for young children's prose learning involve the pictures, the actions, and the written language that are similar or identical with the prose contents. Thus it is possible to study the relations between Bruner's three repersentational modes (enactive, iconic, symbolic) and the young children's prose learning. The main purpose of this study was to present the appropriate instruction media and method in young children's prose learning by investigating the effects of the repersentational modes, the area, and the kinds of word on young children's memory of key words in prose learning. And the other purpose was to give the basic information in selecting the words for instruction throuh the comparison of nouns and adjectives. The hypotheses of this study are as follows: Hypothesis 1. The young children win recall key words differently in ages. Hypothesis 2. The young children win recall key words better in the conditions of enactive representation and iconic representation than in the condition of symbolic representation, Hypothesis 3. The five, six, seven-year-olds will recall more nouns than adjectives. Hypothesis 4. There win be the interaction effect of the ages and the representational modes. Hypothesis 5. There win be the interaction effect of the representational modes and the kinds of word. For subjects in this study, a total of 90 children who know the written language and go to the kindergarten and the elementary school in Guang-Ju, Ma-San were randomly assigned to the three experimental conditone (actions, pictures, witten languages). The experimental instruments were the actions, the 10 pictures, and the 10 cards with the written languages, and the tapes with the prose passages by the experts. Stein's(1978) "Albert Gets Caught" was used for this study as in Jung Yeon-Suk'a paper(1986). The datas were colleted by the response test consisted of ten items that were divided to 0. 1. and 2 degrees by the responses. The collected dates were analized by the repeated 3×3×2 (Ages × Rrpesentational Modes × Kinds of Word) ANOVA. The following findings were obtained: First, the hypothesis 1 was accepted [F(2, 81) = 1.09, p<,01]. The seven-year-olds (the second grades) rememberd key words better then the five-year-olds and the six-year-olds. But the differonce between the memory of the five- year-olds and that of the six-year-olds was not. Second, the hypothesis 2 was accepted [F(2, 51) = 5.56, P<.01]. Namely the significant differences among the conditions of the notions, the pictures, and the written languages were. The means of the three conditions were 6.78, 6.98, 5.92. And be the mean of the iconic repersentation mods was highest. Third, the hypothesis 3 was sccepted [F(1,81) = 39.68. P<.01]. This indicates the main effect of the kinds of word. And this mians that the kinds of word affect the prose learning of the five, six, and seven-year-olds. Forth, the hypothesis 4 was rejected. the degrees in the three representational modes were consistent in disregard of ages. Fifth, the hypothesis 5 was accepted [F(2, 81) = 3.01, P<.10]. The young children remembered relatively well key words of adjectives in the iconic representation mode.
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Treatment of Elastosis Perforans Serpiginosa with the 585-nm Pulsed-dye Laser
( Yeon Gu Choi ),( Sang Yeon Kim ),( Ji Soo Park ),( Kyu Yeon Kim ),( Bo Bin Cha ),( Jin Seop Kim ),( Gyoo Huh ),( Heun Joo Lee ),( Young Jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2
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Choi, Ji Yeon,Hwang, Chul Ju,Lee, Do Yeon,Gu, Sun Mi,Lee, Hee Pom,Choi, Dong Young,Oh, Ki Wan,Han, Sang-Bae,Hong, Jin Tae Springer US 2017 Neuromolecular medicine Vol.19 No.4
<P>Alzheimer’s disease (AD) is pathologically characterized by an excessive accumulation of amyloid-beta (Aβ) fibrils within the brain. We tested the anti-inflammatory and anti-amyloidogenic effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor. We examined whether MMPP (5 mg/kg in drinking water for 1 month) prevents amyloidogenesis and cognitive impairment on AD model mice induced by intraperitoneal LPS (250 μg/kg daily 7 times) injections. Additionally, we investigated the anti-neuroinflammatory and anti-amyloidogenic effect of MMPP (1, 5, and 10 μg/mL) in LPS (1 μg/mL)-treated cultured astrocytes and microglial BV-2 cells. MMPP treatment reduced LPS-induced memory loss. This memory recovery effect was associated with the reduction of LPS-induced inflammatory proteins; cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) as well as activation of microglial cells and astrocytes in the brain. Furthermore, MMPP reduced LPS-induced β-secretase and Aβ generation. In in vitro study, LPS-induced expression of inflammatory proteins and amyloidogenic proteins was decreased in microglial BV-2 cells and cultured astrocytes by MMPP treatment. Moreover, MMPP treatment suppressed DNA binding activities of the activation of STAT3 in in vivo and in vitro. These results indicated that MMPP inhibits LPS-induced amyloidogenesis and neuroinflammation via inhibition of STAT3.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s12017-017-8469-3) contains supplementary material, which is available to authorized users.</P>
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Treatment of elastosis perforans serpiginosa with the 585-nm pulsed dye laser
Yeon-Gu Choi,Jin Seop Kim,Seoung Wan Chae,Young-Jun Choi 대한의학레이저학회 2022 MEDICAL LASERS Vol.11 No.2
Elastosis perforans serpiginosa (EPS) is a rare disorder showing erythematous or skin-colored hyperkeratotic papules with a serpiginous or arcuate distribution. There are various treatment modalities available, but a standard treatment method has not been established. We report the case of a 33-year-old male patient with a 2-month history of grouped, multiple, annular-shaped, scaly erythematous papules on his right anterior neck. A histopathological analysis revealed increased brightly eosinophilic elastic fibers from the papillary dermis through the epidermis and clutching the dermis at the site of the perforation of the elastic fibers. Immunohistochemical analysis revealed abnormal elastic fibers with transepidermal elimination in the papillary dermis on the elastic stain. Based on these features, the lesion was diagnosed as EPS. After treatment with six sessions of the 585-nm pulsed dye laser over 3 weeks, the lesion was cleared without any adverse events and no recurrence was observed 2 months after therapy.
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Clinical outcome of a 1064 nm picosecond Nd:YAG laser in the treatment of melanonychia
( Yeon Gu Choi ),( Gyoo Huh ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yunho Lee ),( Jung Yup Kim ),( Sunmin Yim ),( Heun Joo Lee ),( Young-jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Mangement of melanonychia is often not clear. And there have been no previous study to confirm the efficacy of picosecond laser treatment for melanonychia. Objectives: The aim of this study was to verify the efficacy of 1064 nm picosecond neodymium-doped yttrium aluminum garnet (PSNY) laser in melanonychia without malignant risk. Methods: A retrospective chart review and photo analysis were performed on 9 patients. The patients were included who ruled out malignancy by biopsy or have multiple melanonychia. Also, dermatophyte infection was excluded. Planimetry using Image J software was used to calculate lesion reduction. Clinical improvement was assessed by two blinded dermatologists using a 5-point Global Assessment Scale (GAS). Results: 9 Patients (4 males and 5 females, mean age 38.3 ± 17.0 years, range 20 ~ 65) were analyzed. A total of 38 nails, consisting of 15 finger nails and 23 toe nail, were treated with a 1064 nm PSNY laser, pulse duration of 450 and 750ps, spot size of 3-6 mm, fluence of 1.5-7.0 J/cm2, and pulse rate of 5-10 Hz. The mean interval of treatment was 7.05 ± 5.43 weeks (range: 2 weeks ~ 6 months). The mean treatment session was 3.89 ± 2.15. The average proportion of area of lesions decreased from 33.6% to 26.5% (p < 0.05). The total mean GAS 2.67 ± 0.84 showed fair improvement and no serious adverse event occurred. Conclusion: 1064 nm-PSNY lasers could be an effective option for treatment for benign melanonychia.
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A retrospective analysis of factors affecting effectiveness of cyclosporine in psoriatic patients
( Yeon Gu Choi ),( Jin Seop Kim ),( Gyoo Huh ),( Hyeon Jeong Park ),( Junghwa Yang ),( Yunho Lee ),( Heun Joo Lee ),( Young-jun Choi ),( Won-serk Kim ),( Ga-young Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Cyclosporine is an effective drug for the treatment of psoriasis. Nonetheless, little is known about factors associated with effectiveness of cyclosporine. Objectives: To analyze factors affecting effectiveness of cyclosporine in psoriatic patients. Methods: ‘Good response to treatment’ and ‘treatment failure’ were each defined as who has been achieved 75% improvement in the psoriasis area and severity index (PASI 75) and who has not been achieved PASI 50. The factors affecting good response to treatment were investigated by comparing good response group and the others. Additionally, we analyzed factors affecting treatment failure and the time to achieve PASI 75. Results: Patients 78(63 males and 13 females, mean age 44.9 ± 13.1 years) were analyzed. Baseline PASI score, staring dose, treatment duration, age of onset, accompanying psoriatic arthritis showed a significant relation with PASI 75 achievement. And starting dose, last dose, age of onset showed relation with PASI 50 achievement. The mean time of achieving PASI 75 was 6.70 ± 3.17 weeks and didn’t correlate with any factor. Conclusion: High starting dose, sufficient treatment duration may be considered for successful cyclosporine treatment in psoriatic patients, especially in severe severity, long disease-duration or psoriatic arthritis patient. Also, high starting dose and proper dosage increment may be need for prevention of treatment failure, particularly in long disease-duration patients.
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