Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Development of Sun-Glint Prediction Program For The Communication, Ocean and Meteorological Satellite

Park Jae-Ik,Choi Kyu-Hong,Park Sang-Young,Lee Byoung-Sun,Ahn Yu-Hwan 한국우주과학회 2004 한국우주과학회보 Vol.13 No.2

行列의 固有値와 그 應用

朴淳圭 진주산업대학교 1975 論文集 Vol.13 No.-

As the proper value pure mathematics or applied mathematics is of very important position,I made clear the concept of proper Value and proper vector and studied the method of ca1cu1ation of them in(Ⅱ) In (Ⅲ) I studied the relation between proper value and differential equation Solution. In (iV) I studied the nature of proper value and the problems on Principa1 axis.

웨이브릿 변환 영역의 일반화된 서브밴드 분해 FIR 적응필터를 이용한 채널 등화기

박남천,박순규 慶南大學校 附設 工業技術硏究所 1997 硏究論文集 Vol.15 No.1

웨이브릿 변환 영역의 일반화된 서브밴드 분해 FIR(finite impulse response) 적응 필터를 이용한 새로운 채널 등화기를 구성하였다. 이 적응 필터의 희소 인자는 균일하지 않고 변환 레벨이 1 증가할 때 2 감소 한다. 구성된 적응필터를 이용한 채널 등화기의 수렴 속도를 조사하고 DFT(discrete fourier transform) 변환 영역의 일반화된 FIR 필터를 이용한 채널 등화기의 수렴 속도가 비교 평가하였다. A new channel equalizer using the adaptive filter based on the generalized subband decomposition FIR(finite impulse response) filter in the wavelet transform domain is designed. The sparsity factor of the subfilter used in this adaptive filter is not uniform but decreases by two as the wavelet transform level is increased by one. The convergence speed of the channel equalizer using the designed adaptive filter is tested and compared with the channel equalizer using adaptive filter with the DFT(discrete fourier transform) domain generalized subband FIR filter.

웨이브릿변환을 이용한 서브밴드 구조 FIR 적응필터

박순규,최일홍,김자룡 진주여자전문대학 1996 論文集 Vol.19 No.-

A adaptive filter structure based on the subband decomposition of FIR filter using the wavelet transform is designed and tested. There is no sampling rate alternation in this structure and therefore no aliasing problem occurs. The adaptive noise reduction characteristics using the Harr wavelet transform and DFT are presented and compared. The structure using the Harr wavelet transform is computationally efficient compared to the DFT(FFT) method.

한국어 연속음성의 실시간 주기검출에 관한 연구

박순규,최일홍,황준혁 진주여자전문대학 2002 論文集 Vol.25 No.-

In this thesis, the method for period detection of korean continuous speech recognition, detecting the voice section out of input signal and classification of the voice section by voiced and unvoiced, after period detection in classified voiced. Strong at noise, because of threshold energy stipulate in input signal, possible to detecting the voice section and classification voiced and unvoiced by zero crossing rate(ZCR) and short time energy(STE), period detecting possible as real-time approach by matlab.

마늘成分이 肝 Glutathione S-Transferase 및 Glutathione peroxidase 活性에 미치는 影響

朴鍾珉,李相日,金善業,許瑾,金碩煥,徐赫珪 嶺南大學校 環境問題硏究所 1985 環境硏究 Vol.5 No.2

Garlic (Allium sativum L.) is a widely distributed plant used in all parts of the world not only as a spice but also as a popular remedy for several thousand years Recent studies have shown that garlic components may regulate the many metabolism in liver. Therefore, the present work was undertaken to study the effect of garlicjuice, allicin fraction and heat-treated allicin fraction on the hepatic glutathione s-transferase and glutathione peroxidase which protect against toxic compound and lipid peroxide in liver. The results obtained were summarized as follows. By the treatment of garlic juice, glutathione s-transferase and glutathione peroxidase activity was increased in hepatic cytosolic fraction compare with control group. The enzyme activtiy is more increased by treatment with boiled garlic juice compared with fresh garlic juice in rats. The effect of allicin fraction and heat-treated allicin fraction on the hepatic glutathione s-transferase was observed that these components inhibited the enzyme activity in vitro, whereas the enzyme activity was strongly inhibited heat-treated allicin fraction than allicin fraction. These observation led us to conclude that the garlic components which are a stable substance in heat may regulate the hepatic glutathione s-transferase and glutathione peroxidase activity.

Amorphus Selenium의 K吸收端 微細構造 硏究

朴鍾允,金璿圭,李悳源 成均館大學校 1982 論文集 Vol.31 No.-

The K-abserpsion specterum of Amorphus Selenium were measured. The Speetrometer used is a single Crytal spectrometer which are modified a X-ray diffractometer. There have been several attemps to interpret the extented X-ray abserption fine structure(EXAFS) in terms of the final state interaction of photoelectron with surrounding atoms of the absorbing atom. The general formula of the EXAFS oscillations obtained for uncrystalline Selenium with unpolarized X-ray has been drived. Assuming only the single scattering atoms, the one electron theory with the Muffin-tin potential gives the absorption coefficient for the photoabsorption by an inner core electron with angular momentum. An inner-core electron absorbs the photon and is excited to the final continuum state with angular momentum above the Fermi level. The basic assumption made in the derivation of the formula on our calculation. 1) The absorbing atom phase shifts δ_l' are evaluated assuming neutral atom model. 2) In evaluating the backscattering amplitude f(π), the scattering phase shifts of photoelectron by surrounding atoms are calculated using the core wave function. The comparrison between theory and experiments shows a good agreement.

Mild Cognitive Impairment 노인군의 점화효과 특성

박재우,김도관,고선규,고효정,김성환,김재경,서민영,이인수,김지혜 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.3

연구목적 : 이 연구에서는 K-MMSE에서 25점 이하를 받은 50대 이상 노인들을 MCI(Mild Cognitive Impairment) 군으로 보고 이들의 인지 기능 특성을 점화 효과를 중심으로 살펴보고자 하였다. 먼저, 점화 효과가 MCI 노인군에서 있어서도 유지되고 있는지를 알아보고, 인지 기능의 손상 정도에 따라 점화 효과가 유의미하게 변화하는 지를 살펴보고자 하였다. 방 법 : 본 연구에서는 K-NAME 점수 25점 이하의 노인 96명으 대상으로 ADAS-Cog와 일종의 간접 기억 검사 도구인 지각적 파악 과제를 제작하여 점화 효과를 측정하여 인지 기능의 퇴행이 시작된 고연령군이 나타내는 암묵 기억 능력 특성을 알아보았다. 점화효과는 컴퓨터 상에 사전 노출된 자극과 그렇지 않은 자극을 순간 노출시켜 미리 노출된 자극에 대해 반응 시간이 줄어들고 정확 반응이 증가하는 정도로써 측정하였다. 이 때 지능이나 연령, 학력 수준과 같은 변인이 미치는 영향을 통제하기 위해 한국판 웩슬러 지능 검사의 <어휘>, <토막> 소검사를 실시하였고, 인구통계학적 변인에 관한 면접을 실시하였다. 통계적 분석 과정에서는 먼저, 연구에서 측정된 점화효과의 특성을 알아보기 점화 효과 측정치의 기술 통계치를 구하였으며 다른 측정 변인들과의 상관 분석을 실시하였다. 마지막으로 측정된 점화효과가 인지 기능의 퇴행 수준에 비례하는 지의 여부를 파악하기 위해 ADAS-Cog 및 나이, 교육 연한 및 지능 수준을 독립변인으로 회귀분석을 실시하였다. 결 과 : 먼저 기술 통계 분석 결과에 의하면 본 연구에 참여한 피보험자들의 경우 점화효과에 의해 미리 노출된 자극을 평균 3.6개 더 정확히 파악하였으며 평균 59ms 더 빠르게 반응한 것으로 나타나 이들 집단에서도 점화효과가 유지되고 있음을 알 수 있었다. 다음으로 변인들 간의 상관 분석 결과에 따르면, 정확 파악 반응 점수에 따른 점화효과는 전반적인 인지 기능을 평가하는 K-MMSE 및 ADAS-Cog와 정적인 상관이 있는 것으로 나타났으며 반응 속도로 측정한 점화효과의 경우에는 나이와는 정적인 상관이, KWIS의 <어휘> 소검사 점수와는 부적인 상관이 있는 것으로 나타났다. 또한, 본 연구에서 사용된 점화 효과 측정치를 종속 변인으로 ADAS-Cog와 KWIS의 어휘 및 코막 소검사로 측정한 지능 수준, 나이와 교육 연한과 같은 인구 통계학적 변인을 독립 변인으로 회귀 분석을 실시한 결과에 따르면 정화간응 점수로 측정한 점화 효과의 경우 상관 분석 결과에서와 같이 ADAS-Cog 변인만이 유의미한 효과를 갖는 것으로 나타났으며 반응 속도로 측정한 점화 효과의 경우 나이의 효과만 유의미한 것으로 나타났다. 결 론 : 이러한 결과는 경미한 인지 기능의 손상이 진행되고 있는 고연령군의 경우에는 외현 기억 능력은 손상이 시작되지만 점화효과로 측정된 암묵 기억이 전반적으로는 유지되다가 인지 기능의 퇴행이 진행됨에 따라 노출된 자극을 더 정확히 파악하는 능력이 저하되고 점화 효과에 의해 인출 속도가 빨라지는 현상이 연령이 증가함에 따라 함께 증가하는 것으로 나타남을 말해 준다. Objectives : In this study, the cognitive characteristics, especially priming effect, of above 50 years old age group who had less than 25 points in K-MMSE were investigated. Methods : In this study, an implicit memory test measuring priming effect was made and administered ti old age people who had less than 25 points in k-MMSe in screening session. To control the effect of age, educational level and intelligence, demograohic variables were measured, and the subjects of KWIS, vocabulary and block design were administered. Descriptive statistical analysis of the two priming measures and correlational analysis between variables were done. To test the effect of cognitive functioning on priming effect multiple regression analysis was done. Results : Correlational analysis revealed priming score obtained from correct identification response was positively correlated with K-MMSE and ADAS-Cog. And priming score obtained from mean reaction time was positively correlated with age and negatively correlated with vocabulary substest of KWIS. The regression analysis results indicated from correct identification response, whereas age has significant effect on priming score obtained from mean reaction time. Conclusions : The results revealed that as cognitive deterioration progresses priming effect which identify primed stimulus correctly diminish, and as one grow older within age 50 to 70, priming effect which identifies primed stimulus quickly increase.

우리나라 現行 財務狀態變動表의 有用性에 관한 實證的 檢證

朴範鎬,蔡奎學,孫 敏,李 悠,吳瑗善,全夏成 홍익대학교 경영연구소 1988 경영연구 Vol.12 No.-