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RISS 인기검색어
- 검색키워드
- 저자 : ( Mostafa Saadat ) (검색결과 3 건)
- 무료
- 기관 내 무료
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Apolipoprotein E (APOE) Polymorphisms and Susceptibility to Breast Cancer: A Meta-Analysis
Mostafa Saadat 대한암학회 2012 Cancer Research and Treatment Vol.44 No.2
Purpose Apolipoprotein E (APOE, MIM: 107741) has three functionally distinct isoforms of the protein (E2,E3, and E4), encoded by corresponding alleles ε2, ε3, and ε4, which have been well described. Findings from previous studies investigating association between APOE polymorphisms and breast cancer risk have been inconsistent. The present meta-analysis was conducted in order to investigate association of APOE polymorphisms with risk of breast cancer. Materials and Methods Several electronic databases were used for identification of studies containing information on APOE polymorphisms and breast cancer risk published up to January 2012. We identified 10eligible studies, including 3,835 subjects (2008 patients, and 1,827 healthy controls), that reported on polymorphisms of APOE and risk of breast cancer. Summary odds ratios (ORs) and 95%confidence intervals (CIs) were obtained using a fixed and random-effects models. Results Among studies reported from Asia, an association of the ε4 allele with increased risk of breast cancer, in comparison with the ε3 allele, was observed (OR, 1.56; 95% CI, 1.19 to 2.04; p=0.001). It should be noted that allele ε2 showed no association with breast cancer risk. Among Caucasians,neither the ε4 (OR, 0.99; 95% CI, 0.83 to 1.17; p=0.917) nor the ε2 (OR, 0.92; 95% CI, 0.72 to 1.17;p=0.514) allele showed an association with susceptibility to breast cancer, when compared with the ε3 allele. Carriers of the ε4 allele (E4E4, E4E3, and E4E2 genotypes), in comparison with the E3E3 genotype, showed an association with elevated risk of breast cancer only among Asians (OR, 1.75; 95% CI, 1.23 to 2.47; p=0.002). No publication bias was detected. Conclusion This meta-analysis suggest that the APOEε4 allele is a low-penetrant risk factor for development of breast cancer.
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( Iraj Saadat ),( Roghayyeh Vakili-ghartavol ),( Majid Farvardin-jahromi ),( Mostafa Saadat ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.6
Purpose: To investigate whether the G6721T polymorphism (rs.7003908) of the non-homologous end-joining DNA repair XRCC7 gene contributes to the development of exudative age-related macular degeneration (ARMD). Methods: The present case-control study consisted of 111 patients with exudative ARMD and 112 sex frequency-matched healthy controls that were randomly selected from unrelated volunteers in the same clinic. Genotypes were determined by the Restriction Fragment Length Polymorphism (PCR-RFLP) based method. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for ARMD risk associated with polymorphism of XRCC7. In all analysis the GG genotype was considered to be the reference genotype. Results: There was no significant association between genotypes of XRCC7 and susceptibility to ARMD. Considering the significant difference in age distribution between cases and controls, age was used as a covariate in further analysis. After ORs were adjusted for age, the same result was observed. In the next step we stratified our subjects into outdoor and indoor groups according to their job titles. The outdoor and indoor patients were occupationally exposed to sunlight and not exposed to sunlight, respectively. Our present study showed that among indoor subjects there was no association between XRCC7 polymorphism and susceptibility to ARMD. However, among outdoor subjects, the GT + TT genotypes compared to the GG genotype increased the risk of ARMD (OR, 3.13; 95% CI, 1.04-9.39; p = 0.042). Conclusions: Our study revealed that the T allele of the G6721T polymorphism of XRCC7 increased the risk of ARMD among outdoor subjects.
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Seyyed Mostafa Mirkhalili,Seyyed Abbas Mousavi,Ahmad Ramazani Saadat Abadi,Masoud Sadeghi 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.12
Mesh-reinforced cellulose acetate (CA)-based membranes were prepared for forward osmosis (FO) by immersion precipitation. Casting compositions such as CA percent and 1, 4-dioxane/acetone ratio and also preparation conditions such as evaporation time, coagulation bath and annealing temperatures were tested for membranes’ performance. The results were compared with commercially CTA membranes. The best membrane (17.9% polymer and 1, 4-dioxane/acetone ratio of 1.89) showed water flux of 9.3 L/m2h (LMH) and RSF of 0.536mol NaCl/m2h. Moreover, the membrane structure was reinforced by a polyester mesh, which created micro pores in the back of the membrane. This caused higher water flux and RSF compared to membranes without mesh. FO membrane prepared under best conditions, had a smoother surface than commercial ones. This feature enhances the fouling properties of the membrane, which can be appropriate for wastewater treatment applications.
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