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- 저자 : ( Ismail Simsek ) (검색결과 2 건)
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Effect of urea concentration on microbial Ca precipitation
Mustafa Isık,Levent Altas,Samet Ozcan,Ismail Simsek,Osman Nuri Agdag,Ali Alas 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.6
High calcium concentrations are problematic, because they lead to clogging of pipelines, boilers and heat exchangers through scaling, or malfunctioning of aerobic and anaerobic reactors. Urea hydrolysis provides simultaneously a pH and CO2 increase, both of which are responsible of CaCO3 production. This study was carried out to determine urea concentrations between 5 and 20 mM on ureolytic mixed culture treating synthetic wastewater. The optimum urea concentration was found as 15 mM for effective calcium removal. This work showed the feasibility of urea-based microbial carbonate precipitation as an alternative Ca2+ removal technology.
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The presence of MEFV gene mutations in patients with primary osteoarthritis who require surgery
( Sedat Yilmaz ),( Hakan Erdem ),( Servet Tunay ),( Deniz Torun ),( Halil Genc ),( Yusuf Tunca ),( Omer Karadag ),( Ismail Simsek ),( Muhterem Bahce ),( Salih Pay ),( Ayhan Dinc ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5
Background/Aims: Chronic arthritis of familial Mediterranean fever (FMF) involves weight-bearing joints and can occur in patients without a history of acute attack. Our aim was to investigate a possible causal relationship between FMF and osteoarthritis in a population in which FMF is quite common. Methods: Patients with late stage primary osteoarthritis were enrolled, and five MEFV gene mutations were investigated. The frequency of MEFV gene mutations was compared among patients with osteoarthritis and a previous healthy group from our center. Results: One hundred patients with primary osteoarthritis and 100 healthy controls were studied. The frequency of MEFV gene mutations was significantly lower in the osteoarthritis group (9% vs. 19%). M694V was the most frequent mutation (5%) in the osteoarthritis group, whereas in the control group, E148Q was the most common (16%). In subgroup analyses, the mutation frequency of patients with hip osteoarthritis was not different from that of patients with knee osteoarthritis and controls (7.1%, 9.7%, and 19%, respectively). There were no differences among the three groups with respect to MEFV gene mutations other than E148Q (8.1% vs. 3.6%). E148Q was significantly lower in the osteoarthritis group than in the controls (16% vs. 1%), although the mutations did not differ between patients with knee osteoarthritis and controls. Conclusions: In a population with a high prevalence of MEFV gene mutations, we did not find an increased mutation rate in patients with primary osteoarthritis. Furthermore, we found that some mutations were significantly less frequent in patients with osteoarthritis. Although the number of patients studied was insufficient to claim that E148Q gene mutation protects against osteoarthritis, the potential of this gene merits further investigation.
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