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Case Report : Active Sensitization of Para-tertiary-butylphenol after TRUE Test®
( Hyun Wuk Cha ),( Han Jin Jung ),( Hyun Jung Lim ),( Weon Ju Lee ),( Seok Jong Lee ),( Won Kim ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.5
Active sensitization of contact allergen is an uncommon complication of patch test. Para-tertiary-butylphenol (PTBP) is a component of neoprene-based adhesives used in glued leather goods such as shoes, handbags, belts and watchstraps. Contact allergy to PTBP is frequently seen when the patch test is performed. However, active sensitization to PTBP after the patch test is rare. A 23-year-old female patient came to our clinic with a brownish hyperpigmented patch on the belt position of her belly. Pruritic erythematous papules and vesicles developed on the abdomen when she wore new pants 4 months ago. Under the clinical diagnosis of allergic contact dermatitis, the patient was patch tested with the Thin-layer Rapid Use Epicutaneous Test (TRUE Test®). The result showed strong positive reaction to nickel sulphate and thiomersal both on day 2 and 3 after application. Twenty-nine days after the test, the patient noticed pruritus on the TRUE Test® area. Thirty-four days after the test, an erythematous square-shaped plaque studded with tiny vesicles developed at the PTBP patch test site. This strongly suggests that the reaction to PTBP is occurred. She was diagnosed with an active sensitization to PTBP. We report a rare and interesting case of active sensitization to PTBP after TRUE Test®.
FCP 7 : Cutaneous foreign body reaction induced by retained bee sting
( Hyun Bo Sim ),( Soo Yuhl Chae ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Weon Ju Lee ),( Seok Jong Lee ),( Do Won Kim ),( Yong Hyun Jang ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Reactions to a bee sting ranges from mild erythema to severe anaphylactic reactions. Occasionally, a sting may be retained in the skin and a foreign body reaction to the sting may persist. In traditional Korean medicine, bee sting therapy applies a bee sting directly into a lesion to treat various diseases. Although, some cases about foreign body reaction induced by bee sting were reported, there is no report showing bee sting in biopsy specimens. A 50-year-old woman presented mild pruritic grouped papules on both lip angles for 7 months. She had suffered from recurrent herpes simplex. As a treatment, multiple bee stings had been applied on the the skin lesions several months before. Interestingly, we found apparatuses suspected to be retained stings of bees, which were showed as yellow sticks with central cavity filled with eosinophilic venom in the biopsy specimen. The retained apparatuses were surrounded by hair follicle-like structure and a granulomatous inflammatory cell infiltrate. In H&E staining, that apparatuses were consistent with bee stings. Cutaneous reactions induced by long-standing retention of bee stings in the tissues may cause some difficulties in diagnosis, because of nonspecific, neoplasm-like changes in clinical and histopathological examination. Herein, we report an interesting case of a foreign body reaction induced by retained bee stings, demonstrated in comparison with live bee stings.
( Soo Yuhl Chae ),( Hyun Bo Sim ),( Kyung Hea Park ),( Hyun Wuk Cha ),( Hyun Ho Son ),( Hong Dae Jung ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Microneedle devices have been useful tools to reduce scarring and wrinkling. In addition, microneedle devices have been used in the treatment of pattern hair loss. Objectives: To investigate the efficacy and safety of home-use microneedle for the treatment of pattern hair loss. Methods: A total of 29 patients were enrolled. They were randomized into 3 groups; 5% minoxidil group, home-use microneedle group and their combination group. They were used twice a week. This study was evaluated through macrophotographic hair count, folliscope hair count, investigator`s global assessment (IGA), subject satisfaction score (SSS) and side effects at 0, 1, 3 and 6 months. Results: In all groups, a significant improvement was not shown in macrophotographic hair count (p>0.05) but in folliscope hair count (p<0.05). There was no statistically significant difference in hair count among the three groups (p>0.05). IGA was increased in three groups and 5% minoxidil group showed a statistically significant increase in IGA (p<0.05). SSS showed an improvement in a combination group. Mild and transient pruritus occurred in one patient of home-use microneedle group. Conclusion: Our study showed that a combination of home-use microneedle and 5% minoxidil is not inferior to 5% minoxidil. Home-use microneedle twice weekly is considered as a safe therapeutic modality to stimulate hair growth and to enhance transdermal delivery.