鉛暴露 作業者의 鉛中毒 早期發見을 위한 集團檢診法 改善方案에 관한 硏究

홍대용,김장락,정주화,최현림,윤형렬 慶尙大學校 1995 論文集 Vol.34 No.1

This study was carried out to evaluate the feasibility of current lead indicators used in screening lead who were sspeted to have been exposed to lead were selected as 'case'and 207 female workers from non-lead industry were selected for 'control'. The results obtained were as follows: 1. The mean values of blood lead for case and control were 31.4㎍/dl, 22.2㎍/dl,respectively. The difference observed in the mean concentration between case and control was statistically signifi-ant(P<0.01) 2. The mean values for blood ZPP by hematofluorometer for case and control were 31.3㎍/dl, 25.4㎍/dl,respectiely. And difference between two groups was statistically significant(P<0.01). 3. No statistically significant correlation was found between working duation and blood lead, blood ZPPlovel. 4. According to the simple correlation analysis,ZPPand urine lead were found to be statistically correlated with blood lead(P<0.01) 5. According to the discriminant analysis using blood lead as a dependent variable, it showed 89.1% predictability when using 40㎍/dl as a cutting value which is used as a screenig cutting value for industry workers health examination, while 81.8% for 30㎍/dl,77.54% for 20㎍/dl, respectively. 6. Lead related simptons which is used for screening the lead ntoxicated patients were used as a dependent variables in multiple regression analysis to find useful lead indicator. And significant independent variables were found to be ZPP, Age, and Hct. 7. Above results suggest that objective evalution of feasibbility of several lead indicators should be developed to correct the disutility of current lead screeng system in Korea.

초등 사회과 3학년 지역화 교수·학습자료개발 연구

홍기대,손정선,김언식,김용조,이광성,김경운 光州敎育大學校 初等敎育硏究所 2002 初等敎育硏究 Vol.17 No.-

The purpose of this study is in developing locally-oriented teaching-learning materials to motivate students to effectively take part in activities using map and in improving the field work of social studies to plan a map learning and to give them the ability of practice. It represents the right order involved in teaching the activities using map after doing preceding learning : classroom, playground, and the environs of the school including to some learning methods such as a puzzle map, a correlative of learning. Field trip study planning and lesson-plan are designed in case of Sewage disposal plant, Duknam filtration plant, Bonchon industrial complex relating to field trip study. There are some effects expected which follow through this study. First, teachers are able to draw learner's interest in finding learning sources directly through the community where they live. Second, learners have active participation in class, motivation, drawing their interests through map learning by doing preceding study of learner-centered. Third, teachers can make use of it as useful tools to get high achievement goal with self-direct learning.

백서에서 동종 신경이식시 항 T임파구 단일클론항체 분포에 관한 조직화학적 연구

홍창섭,김경욱,임창준,정대현 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

Nerve allografts as a bridge through which lost nerve can regenerate is useful in the repair of peripheral nerve defect resulting from trauma, neoplasm and leprosy. But immunological rejection and complicated scar formation is an unaboidable problem in the application of allogenic nerves. This article is intended to study histopathological and immunohistochemical response after fresh allogenic sciatic nerve grafts in rats. 12 male Sprague- Dawley rats were used as the experimental animals. A 2cm skin incision was made on the lateral aspects of limb, parallel to the femur. 1cm-long sciatic nerve trunk taken from the one rat was resected at the middle of the to high, and it was transplanted to the same area of the other rat with perineural suture method. Observation was made at the postoperative 1, 3, 8, 16 day. The results were as follows. 1. Histopathologically, destruction of the perineural sheath was observed only in 1-day group. 2. Mild degenerative changes of the nucleus and cytoplasm of Schwann cells were ovserved in the 1-day and 3-day groups. These changes gradually resolved. 3. Hollow space phenomena of the nucleus and cytoplasm of schwann cells were observed. The response was mild in the 1 day and 3 day groups, and moderate in the 8 day group. The phenomena were not identified in the 16 day group. 4. Immunohistochemical studies revealed pan T cells and cytotoxic T cells in the 1 day group. Increased numbers of cytotoxic T Cells and helper T cells were observed in the 3 and 8 day groups. 5. According to these results, after transplantation of fresh allogenic sciatic nerve an inflammatory response was observed up to 8 days and then gradually resolved. Degenerative changes were more severe up to 8 days, but an the 16th day they had resolved histopathologically and immunopathologically.

Caco-2 세포 단층막 투과 실험시 교반이 약물의 투과계수에 미치는 영향

홍순선,유호정,이홍,정석재,김대덕,심창구 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

The unstirred water layer (UWL), which has been known to exist in the boundary of the intestinal lumen and intestinal wall, often behaves as an absorption barrier especially for lipophilic drugs. The intestinal absorption of drugs is often characterized using Caco-2 cell monolayers grown on Transwell polycarbonate membranes. The permeability (Pare) of drugs across the cell monolayer might be influenced by the agitation of the donor compartment, since the width of UWL on the surface of the cell monolayer would be reduced by the agitation. In this study, the effect of agitation of the donor compartment with 60 rpm on the permeability was measured for 12 drugs with a wide range of lipophilicity and permeability. The of mannitol, tributylmethyl ammonium, cimetidine, ranitidine, hydrocortisone, benzylpenicillin and loxoprofen was not influenced by the agitation, while the P_(app) of theophylline, propranolol, YH439, phenylpropanolarnine and testosterone was increased by the agitation. There was a significant correlation between the increase of P_(app) by agitation and the lipophilicity for the compounds having P_(app) > 2 x 10^(-5) cm/sec. No correlation was observed for the difference in P_(app) by agitation and the molecular weight, or lipophilicity of the drugs. Therefore, the agitation rate of the donor compartment in the Caco-2 cell monolayer study should be carefully controlled in order to estimate Pap, reproducibly especially for iipophilic drugs.

대도시 도심지역 일방통행 체계 적용에 관한 연구

김대웅,정웅기,홍익상 嶺南大學校 環境問題硏究所 1999 環境硏究 Vol.18 No.2

요약문본 연구는 대구시 도심지역의 주요 간선도로를 대상으로 일방통행 적용 모의실험을 교통배 분모형을 통하여 행하였다. 일방통행 적용은 도심지역 전체 도로망에 대해 일괄적으로 행하 지 않고, 현실성 있는 일방통행 실현을 위하여 일방통행 대상 도로망을 도로망 형태 및 기 능, 교통량 패턴, 토지이용 특성 등의 기준을 설정하여 선정하였으며, 그 결과 도심지역의 동서간선도로의 경우에는 일방통행 적용 기준에 부적합한 것으로 판단되어 남북간선도로에 대해서만 적용하였다. 일방통행 운영 대안으로는 시내버스 운행과 관련하여 시내버스를 포 함한 일방통행 운영안(대안 1)과 시내버스 제외 일방통행 실시안(대안2) 등 2가지를 설정하 여 분석을 행하였다. 이상의 연구결과를 정리하면 다음과 같다. 첫째, 일방통행 운영 대안별 기대효과 분석 결과, 전차량 일방통행 실시안인 대안(1)이 교통 소통, 신호 및 차로운영, 연도 접근성 등의 여러 측면에서 가장 양호한 대안으로 나타났으 나, 대안(1)의 시행에는 41개 시내버스 노선 변경이라는 현실적인 어려움이 있는 것으로 분 석되었다.둘째, 일방통행 운영 대안별 평균통행속도 분석 결과, 일방통행 실시 대상 8개소 도로구간에 서는 대안별 약 23∼51% 증가, 1차 순환선내 주요 도로망에서는 대안별 약 26∼35% 증가 하는 것으로 분석되어 일방통행 실시에 따른 교통 소통력 개선효과도 매우 좋은 것으로 나 타났다.셋째, 일방통행 운영 대안별 교차로에 있어서 차량의 지체도 및 서비스수준 분석 결과는 2 가지 대안 모두 일방통행 실시전에 비해 교차로에서의 지체도가 대부분 100% 이상 개선되 었으며, 종단부 교통처리도 별 문제가 없는 것으로 분석되었다.Abstractthis study has been conducted a simulation of an oneway operation system using a traffic assignment model at major arterials in the CBD in Taegu city. For adaptiong of oneway operation system, arterials selected according to a criterion of road network types, road network functions, patterns of traffic volume, and land use characteristics, while it does not act of road network in whole CBD.The operating method has been analyzed, one for including city bus of oneway operating method(alternative I), and the other for excluding city bus (alternative Ⅱ). The results are as follow :First, the alternative 1 has been appeared most feasible one concerning for traffic operation, signal and lane operation, accessibility. However, the alternative 1 has been analyzed several problems changing about 41 city bus routes.Second, comparing each operating alternatives with average travel speed, eight places of oneway operations were increased about 23-51% within the first circulation. Therefore, the oneway ooperation is very efficient for traffic flow improvement.Third, the results of car delay and level of service analysis according to intersection analysis of each alternatives of oneway operation have been improved almost 100% efficiently, also there was not a big problem treating traffic operation at the end of oneway operation system.

친환경 방염액의 연구

이순홍,김병량,문명욱,이대정,정영호 안양대학교 산업기술연구소 2004 自然科學硏究 Vol.11 No.1

대구 지하철 참사 이후 사회 전반적으로 방염에 대한 관심이 증대되어 방염제에 대한 연구가 활발하게 진행되고 있는 실정이다. 기존의 할로겐화 방염제는 방염제 자체의 독성으로 인해 인간의 건강과 환경에 유해성이 확인됨에 따라 이를 대체할 친환경 방염제의 연구가 부각되고 있는 시점이다. 본 연구에서는 친환경 대체 방염제의 일환으로 인계와 무기계 방염제를 혼합 사용하여 우수한 방염성능 및 연소시 유독가스가 발생되지 않는 친환경 방염제의 조성을 설계하고자 하였다. 인계 방염제로서 제1인산암모늄, 제2인산암모늄을 사용하였으며, 무기계 방염제로서 붕산과 붕사를 사용하여 각 조성 배합비의 함량 변화 실험을 통한 방염 특성 평가를 수행하였다. 이와 더불어 방염제의 부착률에 따라서 방염효과가 달라지는데, 최적의 조성으로 부착률을 달리하여 경제성과 법적인 측면을 고려하여 가장 효율적인 부착률을 알아보았다. The purpose of this research is to make a non toxic flame retardants as a substitute material for toxic halogen type, and to evaluate burning area, adhesion rate and flammability of non toxic flame retardants. The non toxic flame retardants were prepared by mixing processes of ammonium phosphate monobasic, ammonium phosphate dibasic, boric acid and borax under the various preparation conditions. Flammability of polyester fabrics treated with these mixed flame retardants was investigated through measurement of burning area and adhesion rate. The burning area values were decreased with increase of the Ammonium phosphate monobasic and ammonium phosphate dibasic content of flame retardants. For economic and legal reasons, the optimum adhesion rate of flame retardants on the polyester fabrics was 50%.

국내 데크작업의 생산성 증대에 관한 연구

윤대중,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The use of plates have gone on constantly increasing the slab system of the steel structures in construction field but the productivity of deck plate installation has constantly declined because of the lack of coordination, fragmented nature, and queuing time. This paper provides models for analyzing the complex cause and effect relationships that may lead to a loss of productivity in construction. The purpose of this study is to suggest the methods to improve the productivity and reduce the idle time of the deck plate installation through work sampling, crew balance, work sequence evaluation, and Extend simulation. The model introduced in the paper will provide a new approach to evaluating occurrences of productivity.

Au를 공침한 SnO₂후막센서의 가스 감응 특성

성정훈,강대원,이윤수,임준우,홍영호,이덕동 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

High selective and sensitive thick film type methane gas sensors were fabricated and their sensing characteristics for various hydrocarbon gases were investigated. Raw material, SnO_(2)/Au, prepared by coprecipitation was even grain size. SEM, TEM, BET and XRD analyses were carried out for investigation of surface morphology and crystalline structure. The thick film devices using the above materials exhibited high sensitivity to methane gas at the operating temperature of 400°C. The sensitivity of SnO_(2)/Au+Pd thick film devices to methane gas was higher than that to the other hydrocarbon gases such as iso-butane and propane. The optimal adding amounts of Au and Pd were 1wt.% and 3wt.%, respectively. The sensitivity, S, is defined as {(R_(A)-R_(G))/R_(A)}><100, which R_(A) and R_(G) are resistance in air and that in the gas ambient, respectively.

항균성 펩타이드인 Mastoparan B의 살조효과

서정길,김찬희,배윤정,문호성,김근용,박희연,윤호동,김창훈,변대석,홍용기,박남규 한국어병학회 2003 한국어병학회지 Vol.16 No.3

Mastoparan B (MPB)는 벌독으로부터 정제된 양친매성α-helical 구조를 취하면서 14개의 아미노산 잔기로 구성된 염기성 항균성 펩타이드로서 여러 가지 생물막과 작용한다. 본 연구에서는 우리 나라 연안의 적조 (HABs, harmful algal blooms)를 일으키는 4종의 적조생물 (Alexandrium tamarense, Chattonella catenatum)에 대한 MPB의 살조효과를 조사하였다. MPB의 4종의 적조생물에 대한 살조효과는 31.3㎍/㎖에서 세포의 lysis또는 ecdysis와 같은 형태로 현미경으로 관찰할 수 있었다. 또한 MPB는 C. marina 및 C. polykridorides에 대해서 A. tamarense와 G. catenatum보다 더욱 강한 살조효과를 나타내었다. 이러한 MPB의 HABs에 대한 살조효과연구는 새로운 살조물질을 개발하기 위한 자료가 될 것으로 생각된다. Mastoparan B (MPB), an antimicrobial cationic peptide isolated from the venom of the hornet Vespa basalis, is a basic amphipathic a-helical peptide composed of fourteen amino acid residues. In this study, we have investigated the algicidal effect of MPB against hatmful algae blooms (HABs) casative Alexandrium tamarense, Chattonella marina, Cochlodinium polykrikoides and Gymnodinium catenatum. The algicidal effect of MPB showed in the concentration of 31.3 ㎍/㎖ to 500 ㎍/㎖ against 4 HAB species and observed cell lysis or cell ecdysis by microscopy. MPB reacted more sensitive to C. marina and C.polykrikoides than A. tamarense and G. catenatum. The algicidal study of MPB against HABs will provides much insight into development of new algicidal substances.

근적외선을 이용한 두개강내 혈종의 진단

박정율,홍기선,김상대,김세훈,임동준,조태형 대한체열학회 2003 대한체열진단학회지 Vol.3 No.1