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RISS 인기검색어
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- 저자 : ( Changrong Zhang ) (검색결과 2 건)
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On the Prevention of Juvenile Deviant Behaviors in Adolescence
Changrong Zhang 아시아경찰학회 2011 아시아경찰학회 국제학술회의 Vol.2011 No.-
Juveniles are in a crucial stage of physical and mental development, and are inclined to have deviant behaviors. So the prevention of juvenile deviance is of great significance for the control of juvenile delinquency. This project conducted a sample survey on 5,594 Grade 9 students, discovering a few new juvenile deviant behaviors in adolescence that deserved attention. Both schools and families still lay emphasis on ranking good and bad academic performances based on their scores, which results in more and more prominent negative effects. Prevention of juvenile deviant behaviors is a very important basis for crime prevention, therefore, the whole society should work together to prevent the juvenile deviance and create positive conditions to reduce the juvenile delinquency by improving infrastructure.
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( Qiuke Hou ),( Yongquan Huang ),( Changrong Zhang ),( Shuilian Zhu ),( Peiwu Li ),( Xinlin Chen ),( Zhengkun Hou ),( Fengbin Liu ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.4
Background/Aims MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity in IBS-D remains largely unknown. Methods We established the IBS-D rat model and evaluated it using the nociceptive visceral hypersensitivity test, myeloperoxidase activity assay, restraint stress-induced defecation, and electromyographic (EMG) activity. The distal colon was subjected to miRNA microarray analysis followed by isolation and culture of colonic epithelial cells (CECs). Bioinformatic analysis and further experiments, including dual luciferase assays, quantitative real-time polymerase chain reaction, western blot, and enzyme-linked immunosorbent assay, were used to detect the expression of miRNAs and how it regulates visceral hypersensitivity in IBS-D rats. Results The IBS-D rat model was successfully established. A total of 24 miRNAs were differentially expressed in the distal colon of IBS-D rats; 9 were upregulated and 15 were downregulated. Among them, the most significant upregulation was miR-200a, accompanied by downregulation of cannabinoid receptor 1 (CNR1) and serotonin transporter (SERT). MiR-200a mimic markedly inhibited the expression of CNR1/SERT. Bioinformatic analysis and luciferase assay confirmed that CNR1/SERT are direct targets of miR-200a. Rescue experiments that overexpressed CNR1/SERT significantly abolished the inhibitory effect of miR-200a on the IBS-D rats CECs. Conclusions This study suggests that miR-200a could induce visceral hyperalgesia by targeting the downregulation of CNR1 and SERT, aggravating or leading to the development and progression of IBS-D. MiR-200a may be a regulator of visceral hypersensitivity, which provides potential targets for the treatment of IBS-D. (J Neurogastroenterol Motil 2018;24:656-668)
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