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( Sibel Serin ),( Yildiz Okuturlar ),( Asuman Gedikbasi ),( Esra Demir ),( Sema Ucak Basat ),( Ozlem Harmankaya ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Introduction: Metabolic syndrome (MS) is associated with increased cardiovascular risk. There are a lot of study that is releated with the correlation between metabolic syndrome and low grade inflammation. We have attempted to compare Framingham Risk Score(FRS) that calculates cardiovascular risc rates and Matrix Metalloproteinase- 9 levels that is an aterosclerotic proinflammatory marker, on metabolic syndrome`s between other healties. Method: We included 86 patients that contains 51 MS and 35 healties to this study..In both groups, age, length, weight, BMI, waist circumference, familial hearth disease and HT on family was registered. Framingham risk score (FRS) was calculated. Insulin, glucose, HOMA-IR, total cholesterol, LDL, HDL, Triglyceride levels saved. Blood samples for MMP -9 levels were taken and stored at -80 ℃. MMP-9 levels measured by the way of solid phase platinium ELISA (BIOSOURCE). Results: This case contained 86 patients, 51 of them is MS (%59.3) and the others are called as control group (%40.7). Ages of patients are changed between 20-55 years and the mean age is 38.52±10.02. FRS of MS patients were calculated statistically high compaired to control group (p=0.017). MMP-9 levels of MS patients were calculated statistically high compaired to control group (p=0.001).In both goups, there is no statistically significant relationship between MMP-9 levels and FRS (p>0.05) Conclusion: MMP-9 changes between the groups of MS young aged of 20-55 and health group may show us early atherosclerosis. At the group of high MMP-9 levels, even age releated cardiovasculary hearth disease risks are lower, risk was statistically calculated high compared to the other healthy populations. This situation is important in order to control risk factors as MS at early ages.
( Sibel Serin ),( Yildiz Okuturlar ),( Asuman Gedikbasi ),( Irem Kilic Utku ),( Sema Ucak Basat ),( Ozlem Harmankaya ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Objective: Frequent changes in parameters like blood pressure, plasma lipid changes, waist circumference which are accepted as a metabolic syndrome (MS) are observed in thyroid patients with hypothyroid. In this study we investigated serum levels of TPO which is the diagnosis of hypothyroid and prognosis criteria antithyroid peroxidase antibody (Anti-TPO) in patients with MS and we analysed the correlation with matrix metalloproteinases-9 (MMP-9) which is accepted as an indicator of infl ammation in MS. Method: 51 patients with MS and 35 controls were enrolled in the study. Age, body mass index (BMI), waist circumference and hypertension (HT) values of both group were recorded in the beginning. Medical records of HT were noted and cardiovascular diseases in their family were queried. Insulin, glucose, HOMA-IR, total cholesterol, LDL, HDL, TG, TSH and Anti-TPO levels were measured. Blood samples for measuring MMP- 9 were stored at -80°C. Measurement of MMP-9 was performed by using solid phase platinum ELISA kits (Biosource). Results: Study was performed with 51(59,3%) MS group and 35(40,7%) control group. Both Anti-TPO and MMP-9 levels of patients with MS were statistically and signifi cantly higher than the levels of control group (p<0.01 for both group). There is a statistically signifi cant correlation (positive, 83.2%) between MMP-9 and TPO in patients with MS (p<0.01). There is a statistically signifi cant correlation (positive, 37.5%) between MMP-9 and TPO in controls (p<0.05). Discussion: Researching Anti-TPO in patients with MS might be an indicator of higher rate of both hypothyroid and MS. High levels of both MMP-9 (>76 mg/ml) and TPO show that TPO can be used as a cheaper and more easily provided marker in patients with MS without acute thyroid. Anti-TPO follow-up might be necessary in MS diagnosis and monitoring.
( Meral Mert ),( Yildiz Okuturlar ),( Pinar Karakaya ),( Asuman Gedikbasi ),( Filiz Islim ),( Ozlem Harmankaya ),( Abaki Kumbasar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It has been reported that MPV is increased in diabetes while the status of MPV in prediabetes is not well known. It has been reported that decreasing level of paraoxonase-1 is related to increased probability of development of atherosclerosis and cardiovascular disease (CVD). In this study we compared the mean platelet volume (MPV), paraoxonase-1 (PON) and arylesterase (ARE) levels in patients with the diagnosis of prediabetes and diabetes mellitus (DM). Methods: Forty five prediabetic patients and 135 type 2 diabetic patients were enrolled into the study. Height, weight, BMI, age, gender, smoking, alcohol, exercise, family history of DM and CVD, childbirth, menopause status of all patients were recorded. Routine biochemical tests and A1c, lipid profiles, homocysteine, PON, ARE and MPV levels were performed. Results: Mean age of diabetics and prediabetic patients are 53.4 ±13.7 and 53.0±12.8 respectively. Age, weight, height, BMI and MPV levels were not significantly different in both groups but PON, ARE, A1c and HOMA levels were significantly different (p=0.0001). There were no significant differences in smoking, hypertension, hyperlipidaemia, exercise, coronary heart disease between the two groups. There was no significant correlation between MPV and PON, ARE but there was a negative correlation between Alc, glucose, WBC values and PON, ARE. We also found a negative correlation between triglyceride and PON levels and microalbuminuria and ARE levels. Conclusions: There was no difference in MPV level in both groups having different risk of atherosclerosis and probably because of the limited number of prediabetic patients in our study. However, lower levels of PON and ARE may have been caused by high risk of atherosclerosis in diabetic patients. It would be more reliable to analyse MPV, PON and ARE according to biochemical and clinical conditions.
( Yildiz Okuturlar ),( Meral Mert ),( Pinar Karakaya ),( Aysun Erbahceci Salik ),( Asuman Gedikbasi ),( Nilgul Akalin ),( Ozlem Harmankaya ),( Abaki Kumbasar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Atherosclerosis is one of the most important causes of death worldwide. Detection and prevention of the organ damage and determination of the risk due to atherosclerosis is getting more and more important in recent days. Brachial Intima-Media Thickness (B-IMT), mean platelet volume (MPV), paraoxonase (PON) and arylesterase (ARE) are accepted as markers of atherosclerosis. In this study we aimed to determine the importance of B-IMT, ARE, PON and MPV levels in four patient groups which are expected to have increased risk of atherosclerosis without vascular complications. Methods: A total of 100 patients (32 prediabetic patients = group 1, 13 subclinical hypothyroidism + prediabetic = group 2, 20 subclinical hypothyroidism = group 3, 35 diabetic patients = group 4) are enrolled into the study. Height, weight, BMI, age, gender, smoking, alcohol, exercise, family history of diabetes mellitus and cerebrovasculer disease, childbirth, menopause status and HOMA levels of all patients were recorded. Routine biochemical tests and Alc, lipid profiles, homocysteine, PON, ARE were performed and brachial artery index was measured. Results: There were no significant differences in age, B-IMT, BMI, homocysteine, MPV, PON and LDL, HDL levels between the groups. We found a significant difference in A1c (p=0.001), glucose (p=0.0001), ARE (p=0.0001), triglyceride (p=0.005) and HOMA-R (p=0.0001) levels between groups. The significant correlations were shown in Table-1. Conclusions: The relationship between insulin resistance, lipid profile, TSH, B-IMT, PON, ARE and MPV are not similar in different patient groups. This is probably due to varying degrees of atherosclerosis in patients.
( Yildiz Okuturlar ),( Nilgul Akalin ),( Ozlem Harmankaya ),( Nurten Turan Guner ),( Deniz Yilmaz ),( Asuman Gedikbasi ),( Ozlem Soyluk ),( Meral Mert ),( Abaki Kumbasar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Paraoxonase (PON)-1 is an antioxidant enzyme. It has three known activities, paraoxonase, arylesterase and diazoxonase. It has been reported that PON-1 defi ciency is related to increased susceptibility to development of atherosclerosis and cardiovascular disease. The aim of this study is to evaluate antioxidative status and carotid intima-media thickness (CIMT) in patients with anemia with/without chronic renal failure. Methods: 42 patients with anemia and a control group of 47 patients were enrolled in to the study. Patients were divided into two groups as Group 1 with iron defi ciency anemia and Group 2 with chronic renal failure and anemia of chronic disease and Group 3 as the healthy control group. In all three groups antioxidative status was evaluated by measuring free sulfhydryl groups (-SH = total thiol), paraoxonase and arylesterase levels. CIMT measurements were also performed at the same time. Results: In all three groups, age, weight, average height, gender, presence of diabetes and smoking habit were not signifi cantly different (p>0.05). Hemoglobin levels were 7.85 ± 1.25 in Group 1, 8.62 ± 1.09 in Group 2 and 13.45±1.63 in Group 3. We have found that Arylesterase and -SH levels were decreased both in Group 1 and 2 according to Group 3. Bilateral CIMT was increased only in Group 2. Between group 1 and group 2 the only difference was the the more signifi cant decrease in Arylesterase levels in group 2 (Table 1-2). Conclusion: PON-1 activity and -SH levels may be independently associated with the presence of atherosclerosis.