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심혈관계의 중추조절에 대한 Prostaglandin $F_{2{\alpha}}$의 영향
이상복,김인순,김옥녀,조규철,Lee, S.B.,Kim, I.S.,Kim, O.N.,Cho, K.C. 대한약리학회 1982 대한약리학잡지 Vol.18 No.1
This study was carried out in order to clarify whether the cardiovascular effect of prostaglandin(PG) $F_{2{\alpha}}$ might be centrally mediated. In unrestrained conscious rat, $PGF_{2{\alpha}}$ was administered into the lateral ventricle. The mechanism of action was also studied by observing the interaction with several adrenergic antagonists injected subcutaneously, Indomethacin was administered into lateral ventricle to investigate the role of endogenous $PGF_{2{\alpha}}$ on the central regulation of cardiovascular system. The results were as follows: 1) The intraventricular injection of $PGF_{2{\alpha}}$ produced an increase in blood pressure and heart rate. 2) The pretreatment with phenoxybenzamine (2 mg/g, s.c.) inhited pressor, but not heart rate responses to the intraventricular injection of $PGF_{2{\alpha}}$ $(2{\mu}g/kg)$. 3) The pretreatment with propranolol (1 mg/kg, s.c.) inhibited tachycardia, but not pressor responses to the intraventricular injection of $PGF_{2{\alpha}}(2{\mu}g/kg)$. 4) The intraventricular injection of indomethacin $(40{\mu}g/kg)$ could not induce significant changes in blood preesure and heart rate. 5) The result indicates that intraventricular injection of $PGF_{2{\alpha}}$ produces pressor and tachycardia responses in the unanesthetized rat, and it is mediated primarily by centrally increased sympathetic outflow. But the endogenous $PGF_{2{\alpha}}$ synthetized in the brain seems to play minor role in the direct regulation of cardiovascular system.
심혈관계의 중추조절에 대한 Prostaglandin F<sub>2α</sub>의 영향
이상복(S.B. Lee),김인순(I.S. Kim),김옥녀(O.N. Kim),조규철(K.C. Cho) 대한약리학회 1982 대한약리학잡지 Vol.18 No.1
This study was carried out in order to clarify whether the cardiovascular effect of prostaglandin(PG) F<sub>2α</sub> might be centrally mediated. In unrestrained conscious rat, PGE<sub>2α</sub> was administered into the lateral ventricle. The mechanism of action was also studied by observing the interaction with several adrenergic antagonists injected subcutaneously, Indomethacin was administered into lateral ventricle to investigate the role of endogenous PGE<sub>2α</sub> on the central regulation of cardiovascular system. The results were as follows: 1) The intraventricular injection of PGE<sub>2α</sub> produced an increase in blood pressure and heart rate. 2) The pretreatment with phenoxybenzamine (2 mg/g, s.c.) inhited pressor, but not heart rate responses to the intraventricular injection of PGE<sub>2α</sub> (2μg/kg). 3) The pretreatment with propranolol (1 mg/kg, s.c.) inhibited tachycardia, but not pressor responses to the intraventricular injection of PGE<sub>2α</sub>(2μg/kg). 4) The intraventricular injection of indomethacin (40μg/kg) could not induce significant changes in blood preesure and heart rate. 5) The result indicates that intraventricular injection of PGE<sub>2α</sub> produces pressor and tachycardia responses in the unanesthetized rat, and it is mediated primarily by centrally increased sympathetic outflow. But the endogenous PGE<sub>2α</sub> synthetized in the brain seems to play minor role in the direct regulation of cardiovascular system.
Vanadium이 신장 Na-K-ATPase에 미치는 영향
김인순,이상복,조규철,Kim, I.S.,Lee, S.B.,Cho, K.C. 대한약리학회 1983 대한약리학잡지 Vol.19 No.1
Vanadium is widely distributed in animal tissues and it is supposed to be a regulator of Na-K-ATPase activity. The effect of sodium orthovanadate on Na-K-ATPase activity in rabbit kidney was measured in vitro and compared with that of ouabain. The influence of sodium orthovanadate on the renal function of rabbits was also investigated. 1) Na-K-ATPase activity was decreased by sodium orthovandate at the concentrations of $10^{-7},\;10^{-6},\;10^{-5}\;and\;10^{-4}\;M$ to 73.89, 36.49, 6.50 and 4.99% of the control activity respectively. 2) Na-K-ATPase activity was decreased by ouabain at the concentrations of $10^{-4},\;10^{-3}\;and\;10^{-2}\;M$ to 69.52, 22.84 and 3.88% of the control activity respectively. 3) Urine volume, urinary excretion of $Na^+,\;K^+\;and\;Cl^-$, clearances of inulin and p-amino-hoppuric acid were decreased until after 60 minutes following the administration of sodium orthovanadate 0.5 mg/kg intravenously $Na^+\;reasorption$ rate was not changed and mean arterial pressure was significantly elevated during 60 minutes after the administration of sodium orthovanadate.
Penicillin G 주입이 Furosemide 이뇨작용에 미치는 영향
김인순,이상복,조규철,Kim I.S.,Lee S.B.,Cho K.C. 대한약리학회 1980 대한약리학잡지 Vol.16 No.2
The influence of penicillin G infusion(7.5 units/min/kg) on the diuretic action of furosemide$(250{\mu}g/kg)$ in rabbits was studied to investigate the drug interaction between penicillin G and furosemide. The results were as follows: 1) There was no significant change in renal function in the penicillin G infused rabbits compared with the normal ratbit. 2) In comparison with the control group, a significant increase in ${\triangle}U_{flow},\;{\triangle}U_{Na}V,\;{\triangle}U-kV\;and{\triangle}U_{cl}V$ was noted by 30 minutes following the administration of furosemide in the penicillin G infused group. There was no significant difference in ${\triangle}C_{In},\;{\triangle}C_{PAH}$ between the two groups and ${\triangle}Na^+$ reabsorption rate was significantly decreased in the latter. The potentiating effect of penicillin G on the diuretic action of furosemide should be due to the increased luminal concentration of free form of furosemide, and it may be related to the competitive inhibition of plasma protein binding between the two drugs.
곽인숙,이상복,조병헌,조규철,Kwak I.S.,Lee S.B.,Cho B.H.,Cho K.C. 대한약리학회 1976 대한약리학잡지 Vol.12 No.2
Coptis rhizoma had been applied in the chines medicine as well as in the folk remidies and it was advocated that coptis rhizoma exerts good therapeutic effect in some case of alimentary disorders and other hypotensive ailments. However the basic pharmacology and the mechanism of hypotensive action are not clear. This experiment was carried out in order to reevaluate the pharmacology, especially hypotensive action of coptis rhizoma and to clarify the mechanism of action, in the rabbits and also $LD_{50}$ of coptis rhizoma was determined using mice as experimental animals. The results of the experiment were as follows. 1) $LD_{50}$ to the mice was 69 mg/kg. 2) Blood pressure manifested gradual responses by the fall of -17, -26, -62 mmHg in proportion to the administration of 3, 5, 10 mg/kg of coptis rhizoma extract respectively. 3) No significant differance was observed in heart rate between the normal control group and the coptis rhizoma extract treated group. 4) Administration of coptis rhizoma extract 5 mg/kg to the rabbit pretreated with atropine or avil did not show any significant difference in the blood pressure compared with that of control group. 5) In the rabbit pretreated with coptis rhizoma extract 5mg/kg, the hypotensive effect of epinephrine was significantly inhibited in comparison with that of normal rabbit.
원통형 입자에 따른 관내 차압 전산 해석 및 Ergun식 보정 연구
유승영(S.Y Yoo),임태규(T.G. Lim),이상복(S.B. Lee),노태성(T.S. Roh) 한국전산유체공학회 2012 한국전산유체공학회 학술대회논문집 Vol.2012 No.5
In this study, Pressure drops in a pipe according to cylinderical particle that has been calculated and analyzed. In general, it is used in a interior ballistic cylindrical particle shape. The analysis of 10 cases for Reynolds number has been conducted in 3 cases cylindrical particle. The results have been compared to the Erguns empirical equation which predicts pressure drop in pipe. To reduce difference between the Erguns empirical equation and the numerical results, calibration has been conducted.