Bio-electrode에 의한 Urea정량에 관한 연구(Ⅱ)

나영악 최신의학사 1994 最新醫學 Vol.37 No.2

尿酸測定에 있어서 各種 成分이 미치는 影響

羅永岳 대구보건대학 1983 대구보건대학 論文集 Vol.7 No.-

Many reducing substances present in the sample may effected with thease method. Effects of bilirubin, hemoglobin, glucose and ascorbic acid in the enzymatic method of uric acid were evaluated and compared to those uric acid levels. The results obtained are as follows: 1) Serum bilirubin concentrations of less than 5㎎/㎗ showed negligible effect on the results of uric acid determined by the enzymatic method. But the concentrations of over 5㎎/㎗ showed an increased uric acid levers. 2) Serum hemoglobin concentrations of less than 100㎎/㎗ showed negligible effect on the results of uric acid determined by the enzymatic method. 3) Serum glucose concentrations of less than 500㎎/㎗ have no effect on the result of uric acid determined by the enzymatic method. 4) Ascorbic acid concentrations showed an increased uric acid level in proportion 0.4㎎/㎗ to 5㎎/㎗ of added ascorbic acid. The usual methods are not greatly effected by normal amounts of ascorbic acid, but excessive amounts may lead to high results.

n-Nonane과 Isopropyl alcohol 混合液(抽出液)을 利用한 血淸 Triglycerides 測定法(TRI-25)의 檢討

羅永岳 대한임상병리사협회 1977 임상병리사회지 Vol.9 No.1

Bio-electrode에 의한 Urea정량에 관한 연구(Ⅰ)

나영악 최신의학사 1989 最新醫學 Vol.32 No.1

공복혈당과 당화혈색소를 적용한 당뇨병 이상소견자의 분포 및 특성 - 당뇨병 기진단자를 제외한 성인을 대상으로

권세영,나영악,Kwon, Seyoung,Na, Youngak 대한임상검사과학회 2017 대한임상검사과학회지(KJCLS) Vol.49 No.3

Among the commonly known tools to diagnose diabetes are fasting plasma glucose (FPG), HbA1c., and OGTT known as gold standard. However, there can be many disagreements on the ways to diagnose diabetes. In this study, we examined the differences of the types of diabetes according to the applicability of FPG and HbA1c. Moreover, we evaluated the concordance of diagnosis. We excluded subjects with missing glucose and HbA1c data, as well as those previously diagnosed with diabetes, and those who fasted less than 8 hours. The data of 4,502 subjects (1,956 men and 2,546 women) from the 2015 KNHNES were analyzed. We divided these patients into three categories which are normal, prediabetes, and diabetes, based on the FPG and HbA1c. In men, the number of subjects with FPG ranging from 100 to 125 mg/dL and HbA1c ${\geq}6.5%$ was 23 out of 664, and the number of subjects with FPG < 126 mg/dL and HbA1c ${\geq}6.5%$ was 39 out of 86 newly diagnosed diabetes patients. The concordance rate was as follows: Normal 80.3%, prediabetes 44.9%, and diabetes 54.7%. The coefficient of Cohen's Kappa was 0.322 in men and 0.362 in women; this suggests that both gender showed a low concordance rate. However, when we divided them into two categories (nondiabetes and diabetes), Kappa was 0.582 in men and 0.637 in women, showing a relatively high concordance rate. While all subjects with FPG ${\geq}126mg/dL$ showed a significantly high HOMA IR, all subjects with FPG < 126 mg/dL showed a significantly high QUICKI. Considering the low concordance rate for the diagnosis of diabetes and characteristic of diagnostic tests, it is necessary to combine the related tests for diagnosing diabetes.

인슐린 저항과 B세포 기능이 당뇨병이 없는 성인의 항상성 모델 평가에 의해 결정되는 것에 대한 상대적 요인

권세영,나영악 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.4

Insulin resistance and pancreatic beta cell dysfunction have been established as being related to the diabetes. Lately, what is emphasizing is that those have been shown as something related to the metabolic syndrome and cardiovascular disease. Homeostasis model assessment (HOMA), simple index is calculated on blood levels of fasting glucose and insulin. And HOMA has been widely validated and applied for insulin resistance and pancreatic beta cell dysfunction. We also assessed the factors relative to insulin resistance and β cell function determined by HOMA. The data from the 2010 Korean National Health and Nutrition Examination Survey were used. Analysis was done for 3,465 nondiabetic subjects (male 1,357, female 2,108). At baseline, anthropometric measurements were done and fasting glucose, insulin, lipid (Total cholesterol, HDL cholesterol, LDL cholesterol and Triglycerides) profiles were measured. HOMA-insulin resistance (HOMA-IR) and beta cell function (HOMA β-cell) were calculated from fasting glucose and insulin levels. In male, the value of HOMA-IR and HOMA β-cell was the highest among 30's and decreased as the age increased. In female, the value of HOMA-IR increased with age, while HOMA β-cell decreased. High HOMA-IR and low HOMA β-cell were associated with the highest value of fasting glucose and systolic blood pressure. Low HOMA-IR and high HOMA β-cell showed the lowest concentration of fasting glucose and the highest concentration of HDL cholesterol. High HOMA-IR and high HOMA β-cell were connected with BMI, Total cholesterol, LDL cholesterol, and Triglycerides. There was a negative correlation between HOMA β-cell and age. The correlation coefficients of HOMA-IR and HOMA β-cell showed the highest value among weight, BMI and WC.

자동혈구분석기 Coulter Counter GEN-S(USA)로 측정한 백혈구 백분율 참고치

김영활,나영악 대구보건대학 2005 대구보건대학 論文集 Vol.25 No.-

The correlation and reference value between Coulter GEN-S and the manual leukocyte shows as fellows : 1. Reference value of WBC count : 3.5-9.9×10^(3)/㎣ (Male: 4.1-10.5, Female: 3.6-9.2). 2. Correlation for neutrophils for neutrophils(r=0.88), Reference value of neutrophils : 37.2-71.2% (Male: 38.0-71.2, Female: 36.5-71.3). 3. Correlatioin for lymphocytes(r=0.76), Reference value of lymphocytes : 20.5-52.5% (Male: 19.9-51.1, Female: 21.4-53.4). 4. Correlation for monocytes(r=0.52), Reference value of monocytes : 3.2-9.6% (Male: 3.2-10.0, Female: 3.0-9.4). 5. Correlation for eosinophils(r=0.89), Reference value of eosinophils : 0.0-5.9% (Male: 0.0-6.5, Female: 0.0-5.4). 6. Correlation for basophils (r=0.18), Reference value of basophils : 0.0-1.4% (Male: 0.0-1.1, Female:0.0-1.7).

우리나라 성인에서 성별과 연령에 따른 이상지질혈증의 분포 및 특성

권세영,나영악 대구보건대학 2013 대구보건대학 論文集 Vol.33 No.-

Dyslipidemia is a major risk factor of cardiovascular disease(CVD). NCEP-ATP Ⅲ guideline has been most commonly used for the management of dyslipidemia. However, new guideline was lately proposed by the Korean Society of Lipidology and Atherosclerosis(KSLA). In this study, data form the 2009 Korean National Health and Nutrition Examination Survery (NHNES) was used and analysed, using strict guideline in korea. Analysis was done for 1,992 subjects with Lipid results(T-CHO, LDL-C, HDL-C, TG). When KSLA guidelines was used, the rate of each study result showed as follows: hypercholesterolemia(≥230) was 12.8%, hyperLDLcholesterolemia(≥150) was 10.9%, hypoHDLcholesterolemia(<40) was 26.4%, hypertriglyceridemia(≥200) was 17.4%. The rate of dyslipidemia was higher when KSLA guidelines were applied than NCEP-ATP Ⅲ guidelines were used. The rate of hypoHDLcholesterolemia was 26.4% among Korean adults which is the highest. The normal rate of dyslipidemia in males was 50.3%, especially 38.6% among 50's showing lowest rate. The rate of dyslipidemia in males who have one item was 28.4%, ones who have tow items was 25.9%, ones who have more than 3 items was 7.1%. The normal percentage of dyslipidemia in females was 64.9%, while female in their 70's showed the lowest. As age is higher, the number of dyslipidemia increases.

작업의 특징적인 특성에 따른 톨루엔 노출 근로자에서 요중 마뇨 산의 농도

권세영,나영악,김상락 대한임상검사과학회 2012 대한임상검사과학회지(KJCLS) Vol.44 No.1

This study is assessed the urinary hippuric acid (HA) concentration in toluene-exposed workers. Toluene is widely used in the coating, printing, painting and petroleum industries. We analyzed the hippuric acid level of toluene-exposed workers (males: 198, females: 63) from 2008 to 2010 and examined the relationship between hippuric acid and the characteristics of their work. The measurements of the urinary hippuric acid were confirmed by high-performance liquid chromatography. Among the subjects, males had on average more work experience than females (males: 9.17 years, females: 4.45 years), but females showed a higher hippuric acid concentration levels than males (males: 0.26 g/L, females: 0.75 g/L). The mean of the HA concentration according to the age group was 0.19 g/L in 30’s, 0.30 g/L in 40’s, 0.54 g/L in 50’s, 1.36 g/L in 60’s. Those in their 60’s had the highest concentration. The mean of HA concentration according to the type of work was 0.70 g/L for the coating, 0.52 g/L for the painting, and 0.16 g/L for the printing industries, revealing that the workers in the coating industry had the highest concentration. By the highest order, the mean of HA concentration by working period was as follows; less than 5 years, ≤5 years~<10 years. The factors that influence the HA concentration are not only how long one is exposed to toluene but also the type of work, worker’s age, and their gender. .

우리나라 청소년에서 혈청과 뇨의 크레아티닌 농도

권세영,나영악 대한임상검사과학회 2014 대한임상검사과학회지(KJCLS) Vol.46 No.4

Creatinine is a general marker as a screening test for renal disease. This study was conducted to provide basic data about pediatric concentration for serum and urine creatinine. The data from the 2011 Korean National Health and Nutrition Examination Survey was used. Analysis was done on 488 Children and Adolescents (boys 278, girls 210) aged 10 to 19, the Jaffe reaction method was used to gather the data. The highest serum creatinine levels were found in boys aged 19 to 20 years, the mean being 0.97 mg/dL (min 0.81 mg/dL, max 1.14 mg/dL). The levels showed increase over those in the 10 year old group. The highest urine creatinine levels were found aged 19 to 20 years, and the mean was 222.68 mg/dL (min 133 mg/dL, max 324 mg/dL). In the case of girls, the highest serum creatinine levels were found with those aged between 18 and 19, the mean being 0.71 mg/dL (min 0.49 mg/dL, max 0.84 mg/dL). The levels showed increase over the 11 to 18 year old group. The highest urine creatinine levels were found aged 14 to 15 years, and the mean was 218.44 mg/dL (min 131 mg/dL, max 321 mg/dL). The mean difference in serum creatinine in all age groups was statistically significant except for those aged 10 to 14, that of urine creatinine in all age groups was not significant statistically except for those aged 12 to 13, 17 to 18. Therefore, it is suggested that reference values for children and adolescents should be divided into different groups according to gender, further studies are needed using complementing data of the pediatrics.