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- 저자 : 황치원(Chee Won Whang) (검색결과 1 건)
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한의학(韓醫學)에서 분류하는 사상체질(四象體質)에 따른 이식항원(移植抗原) HLA-DR 유전자(遺傳子) polymorphism에 관한 연구
권택부(Taek Boo Kwon),황치원(Chee Won Whang),설인찬(In Chan Sul),이경옥(Kyung Ok Lee),황규원(Kyu Yoon Hwang),양동호(Dong Ho Yang),홍세용(Sae Yong Hong) 대한내과학회 2000 대한내과학회지 Vol.58 No.1
N/A Background : In Korean traditional medicine, human beings are classified into 4 groups accordance with the characteristics of physical constitution, named ; Taeum, Taeyang, Soum, and Soyang. Most of Korean traditional doctors believe that the back ground of pathophysiology is differ among each group in many diseases. HLA is the most polymorphic gene and related with human immune response. It has been used for determination of individual identification, genetic diversity and a study of disease association in different ethnic group. It has well known that the most human inflammatory disease which thought to have some autoimmune basis are in some way promoted by genes of the HLA region. The purpose of this study is to observe the distribution of HLA-DR genotypes in 4 types of physical constitution in Korean traditional medicine. Methods : Three hundred and ten Korean subjects(Soyang : 58cases, Soum :142cases, Taeum : 92cases, Taeyang : 18cases) were enrolled for this study. Genomic DNAs extracted by phenol/chroloform were amplified with allele specific primers and determined by 2% agarose gel electrophoresis with ethidium bromide staining for analysis of HLA-DR polymorphism. Results : The genotype frequency of HLA-DR in a total or 310 Koreans was DR1 ; 7.2%, DR 2; 10.5%, DR 3;1.7%, DR 4; 19.9%, DR 5; 11.9%, DR 6;19.9%, DR 7; 7.0%, DR 8; 10.6%, DR 9; 8.7%, DR10;1.9%. There was no significant diffrence of HLA-DR genotype distribution among four physical constitution groups classified by Korean traditional medicine. Conclusion : Our results suggest that the classification of physical constitution in Korean traditional medicine is not related to HLA-DR genotypes.(Korean J Med 58:91-101, 2000)
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