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홍한나 ( Han Nah Hong ),이윤희 ( Yoon Hee Lee ),이원수 ( Won Soo Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.9
Milia are small, white to yellow, benign, superficial keratinous cysts. They are divided into primary or secondary cysts. Secondary milia are associated with disease, medication, and trauma. We report a case of a 45 year-old woman with grouped yellowish papules and brownish patches on her left ankle after bullous cellulitis. This case shows that bullous cellulitis may be one of the causes of secondary milia. (Korean J Dermatol 2011;49(9):840~842)
홍한나 ( Han Nah Hong ),이윤희 ( Yoon Hee Lee ),전수영 ( Soo Young Jeon ),이상훈 ( Sang Hoon Lee ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.12
A 52-year-old man presented with a brown to black nodule on his left cheek. Histological examination revealed nests of nevus cells throughout the upper and mid-dermis. An eosinophilic oval-shaped bony structure was found within the nevus. We report here on a case of nevus of Nanta combined with metastatic renal cell carcinoma. (Korean J Dermatol 2010;48(12):1111∼1113)
강원지역에서 10년간(1999~2008) 내원 환자 중 피부악성종양과 피부암전구증에 관한 임상적 고찰
홍한나 ( Han Nah Hong ),지재홍 ( Jae Hong Ji ),최응호 ( Eung Ho Choi ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.2
Background: The incidence of cutaneous malignant tumors and premalignant lesions has recently increased according to extended life span, social and medical environment changes. However, a few clinical data have been reported on the survey of cutaneous malignant tumors and premalignant lesions in Gangwon province. Objective: To investigate the incidence and clinical patterns of cutaneous malignant tumors and premalignant lesions in Gangwon province. Methods: We reviewed 485 cases of cutaneous malignant tumors and premalignant lesions from January 1999 to December 2008, at the Department of Dermatology at Wonju Christian Hospital. Results: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 0.51% and that of premalignant lesions was 0.48%. Both incidences tended to increase with time in 10 year intervals. The most common cutaneous malignant tumor was basal cell carcinoma (47.98%), followed by squamous cell carcinoma (24.19%), extramammary paget`s disease (7.26%), metastatic cancer (5.65%), malignant melanoma (4.44%), and lastly, lymphoma (4.44%). Among premalignant lesions, actinic keratosis (74.68%) and Bowen`s disease (25.32%) were common. The mean age of onset was 67.53 years in cutaneous malignant tumors and 70.51 years in premalignant lesioins. The most common site for both, the cutaneous malignant tumors and premalignant tumors, was the face (63.97% and 81.43%, respectively). The ratio of men to women was 1.11:1 in cutaneous malignant tumors and 1:2.48 in premalignant lesions. Conclusion: The incidence of cutaneous malignant tumors and premalignant lesions has gradually increased in Gangwon province. This data will be made available for the study about the association of cutaneous malignant tumors and premalignant lesions. (Korean J Dermatol 2012;50(2):95~100)
홍한나 ( Han Nah Hong ),이성율 ( Sung Yul Lee ),전수영 ( Soo Young Jeon ),박하나 ( Ha Na Bak ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.8
A cholesterol embolism is a systemic disease resulting from the occlusion of arteries by cholesterol crystals released from atheromatous plaques. It has been associated with inflammation, sheering forces from blood flow due to hypertension, aneurysm formation, infection, mechanical manipulation during surgery or vascular procedures, and anticoagulation. We report a case of a cutaneous cholesterol embolism in a 66-year old man who had purpuric skin lesions on both feet associated with diabetes mellitus, hypertension, and anticoagulation for a cerebral infarction. (Korean J Dermatol 2011;49(8):762∼764)
이해진 ( Hae Jin Lee ),정예진 ( Ye Jin Jung ),김재홍 ( Jae Hong Kim ),홍한나 ( Han Nah Hong ),최응호 ( Eung Ho Choi ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.10
Dystrophic epidermolysis bullosa is a rare, chronic non-inflammatory bullous disease with a hereditary pattern of occurrence, and this disease easily produces bullae that heal with scarring and milium formation. A 13-month-old female baby was brought to the department of dermatology with multiple variable sized bullae and erythematous to dark brownish patches and crusts on both her feet. The histopathologic findings showed subepidermal non-inflammatory blisters and the electron microscopic findings showed vacuolization of the sublamina densa and broken anchoring fibrils. On the basis of the clinical and microscopic findings, she was diagnosed as having dominant dystrophic epidermolysis bullosa. We report here on a case of dominant dystrophic epidermolysis bullosa with the clinical, histological and electron microscopic findings, as well as the family history of the patient. (Korean J Dermatol 2010;48(10):889~892)
알레르기접촉피부염 환자(영서지역, 2005~2010년)의 첩포검사(TRUE Test) 결과에 관한 고찰
설근동 ( Geun Dong Sul ),이성율 ( Sung Yul Lee ),김재홍 ( Jae Hong Kim ),홍한나 ( Han Nah Hong ),천재순 ( Jae Sun Chun ),안성구 ( Sung Ku Ahn ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Background: Since 2005, the commercial patch test panel, the TRUE-test, has been available. However, there have been no reports regarding the results of the TRUE-test compared with previously used Korean Standard Series in Korea. Objective: This study aimed to evaluate the prevalence of the contact allergy, causative allergens, and source of allergens in patients who were diagnosed with allergic contact dermatitis, and to compare the findings with previously used Korean Standard Series. Methods: We reviewed the results of the TRUE-test from 2005~2010 in Wonju Christian Hospital. We patch-tested 843 patients who were diagnosed with allergic contact dermatitis. The patch test reading was performed on day 2 and days 3 or 4, according to the patients` needs. Epidemiologic findings of patients and the results of the patch tests were analyzed. Results: A total of 843 patch-tested cases were compiled and analyzed. Of 843 patch-tested patients (male, 309; female, 534), 65.8% had at least 1 positive reaction and 30.2% at least 2 positive reactions. The highest age distribution was the 5th decade in females. The face, with the exception of the eyelids, ears, and lips, was the most frequently affected site (comprising 50.3%). The highest sensitization rates were found with nickel (29.1%), thiomersal (10.9%), and cobalt dichloride (9.7%). The lowest positivity included caine mix (0.7%), mercaptobenzothiazole (1.2%), and quinolone mix (1.2%). Metal allergens displayed higher positive rates than any other standard allergens. The overall prevalence was similar with a recent report in Korea. Conclusion: There was no significant difference in the overall prevalence of the most sensitized allergen compared with the reports about previously used Korean standard series.
MTHFR 유전자 돌연변이로 인한 고호모시스테인혈증 환자에게서 발생한 울혈반모양 혈관병증
전인경 ( In Kyung Jeon ),김보경 ( Bo Kyung Kim ),이해진 ( Hae Jin Lee ),홍한나 ( Han Nah Hong ),최응호 ( Eung Ho Choi ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.4
Livedoid vasculopathy is a hyalinizing vascular disease characterized by thrombosis and ulceration of the lower extremities. It can be caused by an alteration in control of coagulation with the formation of thrombi within dermal blood vessels. We report a case of livedoid vasculopathy with hyperhomocysteinemia due to MTHFR mutation, which is treated by folic acid and which also showed very unusual clinical manifestations. A 38-year-old male visited the department of dermatology with a 1 year history of purplish-brown purpura with punched-out ulcers on both lower legs. He had a history of homocysteinemia due to methylene tetrahydrofolate reductase (MTHFR) mutation. The histopathologic findings of the lesional skin revealed dense superficial and deep perivascular and perifollicular infiltrates of lymphocytes and fibrin deposition within the vessels in the dermis. On the basis of clinical and pathological findings, livedoid vasculopathy with hyperhomocysteinemia due to MTHFR mutation was diagnosed and improved by the treatment of 1 mg of folic acid daily. (Korean J Dermatol 2013;51(4):276∼279).