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홍재익 中央醫學社 1971 中央醫學 Vol.20 No.4
Fifty male and female albino rats were divided into five groups; I. control group, II. total body X-irradiation group (400r, single dose), III. prednisolone administration group (2mg/kg/day), IV. Imur an administration group (5mg/kg/day), and V. splenectomized group. The prednisolone and Imuran administration were started 7 days before graft and continued until completion of rejection. X-irradiation and splenectomy were done 24 .hours before graft. Full thickness skin homograft of about 2cmX2cm in size was transplanted on the back of ten rats of each group and the grafts were studied histologically from the 3rd day of operation. The results were as follows. 1. In control group, early neutrophilic infiltration started on the 3rd or 4th day of operation, followed by lymphocytic infiltration on the 4th or 5th day. Vascular proliferation and recanalization was noted from the 4th day, followed by degenerative changes on the 5th or 6th day. The epidermis showed vacuolization of the cells or homogenization from the 5th or 6th day. The grafted junction appeared firmly connected on the 5th day, soon followed by splitting from the 6th day. 2. In total body X-irradiation group, the histologic changes were similar as control group, but the splitting of the grafted junction was delayed until 13th day of operation. 3. In the group of Imuran administration, all the histologic changes described on the control group were delayed, i.e., 3 to 4 days. 4. In the group of prednisolone, all of the histologic changes were similar to those of control group except that the splitting was delayed for 2 to 3 days.
매독환자 혈청의 Immune Globulin 정량에 관한 연구
홍재익 대한피부과학회 1971 大韓皮膚科學會誌 Vol.9 No.3
The sera of 86 patients with untreated secondary syphilis were anaIyzed by immunoelectrophoresis with the specific antisyphilitic rabbit serum. Twenty-seven out of the 86 sera (31. 4%) showed more prominent IgA precipitate arcs as compared to the precipitate arcs of the normal serum. Fourteen out of the 86 scra (16. 3%) showed more promincnt IgM precipitate arcs as compared to the normal. However there was no speciific abnormal precipitate line for the syphilis serum, Quantitative analyscs of the 86 sera from the syphilitics by the Lim's modification of the Oudin capillary tube method showed that the mean of the IgG level is 2.415+53.2mg/100ml, IgA 293+8.3mg/100mI and Igm 102+3.6mg/100ml. This result represents a statistically significant increases of immune globulin levels in the syphilitics as compared with the normal controls (p$lt;0.05).
슬관절(膝關節)에 발생한 심상성낭창(尋常性狼瘡)의 1예
임수덕,홍재익,홍정자 대한피부과학회 1971 大韓皮膚科學會誌 Vol.9 No.2
A case of lupus vulgaris who has the typical skin lesion on the patella region of the right knee was presented. The patient is 9 years old, the generally healthy male, and is no special finding of chest X-ray but tuberculin test was strong positive. The skin lesion started about 2 years ago as baby's palm sized erythematous patch with apple jelly nodule on the right knee joint region. Diagnosis was made by characteristic of clinical appearance and histulagial finding including other laboratory data. The treatment was done with INAH, PAS, streptomycin and pyridoxine for 3 months. Now,The skin lesion is almost healed and still continue treatment and observation go on.
신실,홍재익 대한피부과학회 1971 大韓皮膚科學會誌 Vol.9 No.2
One case of malignant acanthosis nigicans associated with gastric adenocarcinoma (scirrhous type) and papilloma on the oral mucosa is presented. The patient, 36 year old Korean male, visited S.N.U.H, complaining of sore-mouth and sore-tongue of 20 days duration. He had been affected with severe papillomatosis on the oral mucosa and with hyperkeratosis on the periorbital area, the perioral area, the neck, the axillae, the palms, the umbilical area, the inguinal area, the anogenital area and the soles which were moderately hyperpigmented with grayish to brown color. He had not been complaining of G-I troubles except sore-mouth and sore-tongue, but he was diagnosed as stomach carcinoma by gastroendoscopy, He got an operation of extended total gastrectomy with isoperistaltic jejunal interposition. Post-operative histopathologic examination rvealed well differentiated adenocarcinoma of the stomach which had already metastasized to the neighboring lymph nodes. After operation the papillomatosis on the oral mucosa and skin eruptions had been improved but becarne aggravated again one and half month after discharge.
유극세포암 (有棘細胞癌) 을 병발한 색소성건피증의 Bleomycin 에 의한 치험예 (治驗例)
임수덕,김풍명,홍재익 대한피부과학회 1971 대한피부과학회지 Vol.9 No.2
Xeroderma pigmentosum, a rare, genetically determined dermatosis, is often cornplicated by malignant chagnes of various types-most commonly, basal-cell epithelioma, squamous cell epithelioma, less frequently malignant meIanoma, keratoacanthoma, fibrosarcoma, and endothelioma have been reported. In Korea, no case has ever been reported in literature except four cases at a symposium for dermatology, two of them complicated by basal-cell epithelioma, and the others by squamous cell epithelioma. This case reported was complicated by squamous cell epithelioma. As one of the anticancer treatments, especially for skin cancer, Bleomycin is, now, drawing the attention for its high therapeutic index with only few side effects. For this case, we injected Rleomycin 15mg at once, twice a week, for 8 weeks, So total injection was 16 times and 240mg of Bleomycin was given in total. While this amount given for this case was not enough for the complete treatment of squamous cell epithelioma, we got the following results: 1. Clinically, the ulcerated lesion of the cancer on the right ala nasi had shrunken in size with reepithelialization at the margin showing clear surface, and 2. microscopically, the atypical cancer cell masses and individual cell keratinizations had been decreased in size and in number, and less remarkable comparing to those in untreated stage at his first visit to the hospital.