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이애영,홍양의 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Mechanisms of cognitive impairments in idiopathic Parkinson's disease are still controversial. To assess the clinical value of frontal lobe dysfunctions affecting on the level of overall intelligence in parkinsonian patients, I evaluated many clinical and neuropsychological variables which are representative of frontal lobe functions. Thirty one patients with idiopathic Parkinson's disease were included. The mean value of intelligence using the Korean-Mini Mental State Examination was 24.7 and there was no correlation between the Korean Mini-Mental-State Examination score and the severity of disease. Parkinsonian patients showed severe depression on the base of` the Beck Depression Inventory score but there was no relationship between the severity of depression and level of cognition. The frontal lobe functions evaluated with Category Fluency Test and Wisconsin Card Sorting Test were impaired markedly in parkinsonian patients. In conclusion, the frontal lobe dysfunctions in patients with Parkinson's disease may play an important role in deterioration of cognition.