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폴리(에틸렌글라이콜), 폴리카프로락톤, 및 폴리(락타이드-co-글라이콜라이드)로 구성된 트리블록 공중합체의 합성과 임계 마이셀 농도 결정
조영호 ( Young Ho Cho ),현훈 ( Hoon Hyun ),이재호 ( Jae Ho Lee ),정성찬 ( Sung Chan Jeong ),송인범 ( In Bum Song ),이봉 ( Bong Lee ),김문석 ( Moon Suk Kim ),강길선 ( Gil Son Khang ),이종문 ( John M. Rhee ),이해방 ( Hai Bang Lee 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.4
To use macroinitiator, methoxy poly(ethylene glycol)-block-polycaprolactone (MPEG-PCL) diblock copolymer was synthesized by the ring opening polymerization of CL with MPEG as an initiator. Also, MPEG-PCL diblock copolymer as a macroinitiator was synthesized by the ring-opening polymerization of CL under the existence of HCl·Et2O at room temperature. Successively, we synthesized triblock copolymers, methoxy poly(ethylene glycol)-block-polycaprolactone-block-polycaprolactone (MPEG-PCL-PCL), methoxy poly(ethylene glycol)-blockpolycaprolactone- block-poly(L-lactic acid) (MPEG-PCL-PLLA), and methoxy poly(ethylene glycol)-block-polycaprolactone- block-poly(L-lactide-co-glycolide) (MPEG-PCL-PLGA (mole ratio 50:50)). The properties of synthesized triblock copolymer were analyzed by 1H-NMR, GPC, FT-IR, DSC, and XRD. Critical micelle concentration (CMC) of these triblock copolymer was determined by fluorescence spectrophotometer. Micelle formation of these triblock copolymer using D2O was confirmed by 1H-NMR. The diameter and shape of micelle was measured by ELS and AFM. In conclusion, we could prepare the triblock copolymer with different polyester blocks and found the dependance of CMC with respect to characteristic polyester blocks.
온도 감응성 MPEG-PCL 하이드로젤에 함유된 신경성장인자 BDNF의 서방화
조미희 ( Mi Hee Cho ),김선경 ( Sun Kyung Kim ),현훈 ( Hoon Hyun ),신유나 ( Yu Na Shin ),김문석 ( Moon Suk Kim ),이봉 ( Bong Lee ),이정식 ( Jeong Sik Lee ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ),이일우 ( Il Woo Lee ) 한국조직공학과 재생의학회 2006 조직공학과 재생의학 Vol.3 No.1
Methoxy poly(ethyleneglycol) (MPEG)-b-poly(ε-caprolactone) (PCL) diblock copolymer was synthesized by ring-opening of ε-caprolactone (ε-CL) in the presence of HCl · Et2O as a monomer activator with the terminal alcohol of methoxy poly(ethyleneglycol) (MPEG) as an initiator. The temperature sensitive behavior of the prepared MPEG-PCL diblock copolymer was examined in aqueous. The MPEG-PCL diblock copolymer was dissolved in water at 80 oC. The polymer solutions formed translucent sol around at the room temperature. The formed sol became gel at 31 oC as the temperature increased. On further increase of the temperature, the gel changed to sol at 52 oC. This indicates the diblock copolymer solutions at room temperature can form gel at body temperature. Albumin or brain derived neurotrophic factor (BDNF) loaded MPEG-PCL diblock copolymer solution was prepared to observe the release behavior of protein or growth factor. The release profile of albumin or BDNF in MPEG-PCL gel showed the sustained zero-order release for 20 days. In conclusion, we confirmed that MPEG-PCL diblock copolymer solutions is useful as protein or BDNF carriers.
온도 감응성 MPEG-PCL 하이드로젤을 이용한 단백질의 서방화
서광수 ( Kwang Su Seo ),홍금덕 ( Keum Duck Hong ),현훈 ( Hoon Hyun ),김문석 ( Moon Suk Kim ),강길선 ( Gil Son Khang ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.2
The temperature sensitive hydrogels were synthesized by the terminal alcohol of methoxy poly(ethyleneglycol) (MPEG) as an initiator via ring-opening of ε-caprolactone (ε-CL) in the presence of HCl·Et2O as a monomer activator. The gel-to-sol transitions of MPEG-PCL diblock copolymer solutions were also examined in deionized water according to polymer concentration. The MPEG-PCL block copolymers were dissolved in water at 80oC and stored at 4oC for 15 hours. The polymer solutions formed sol around at the room temperature. The formed sol became gel from 31oC to 53oC by increasing the temperature. To observe the release behavior of protein based on MPEG-PCL block copolymers, hydrogels loaded proteins such as albumin, insulin, and dextran were easily fabricated by mixing polymer solution and proteins. The release profile of proteins in MPEG-PCL hydrogels showed the sustained zero-order release without initial burst for 20 days. In conclusion, we confirmed that MPEG-PCL temperature sensitive hydrogels is useful as controlled protein carriers.