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최재청,허양훈 대한물리치료학회 1998 대한물리치료학회지 Vol.10 No.2
Twelve Spraque-Dawley healthy male rats(average weight : 250g)were used to study the morphological changes of mitochondria, myofibrit; muscle cell nucleus, triad, They were devided into 3 groups : normal daily activity (Group 1), 2 weeks immobilization (Group 2), 4 weeks immobilization (Group 3). Left ankle of Group 2 and 3 were immobilized with plaster cast in 65° plantarflexed position. The gastronemius were removed from 12 rats. Muscle fibers were observed electronmicroscopically by double staining with uranyl acetate and lead citrate. All the variables of Group 2 and 3 that selected in this study were significantly decreased when compared with control value (p$lt;.05) but also muscle fibers showed extensive damage, characterized by irregularity of mitochondrias and wide separation of myofibrils; irregularity and thinness of myofilaments and abnormal shape of muscle cell nucleus and unclear triad. Especially, sarcomere length of Group 3 were significantly decreased when compared with Group 2 (p$lt;.01).