http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 한현정(Hyun J. Han) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Eicosanoids가 뇌허혈증 흰쥐의 에너지대사 및 Ca++ 이동에 미치는 영향
한현정(Hyun J. Han),이용규(Youg K. Lee),신정희(Jeung H. Shin),윤재순(Jae S. Yun) 대한약학회 1994 약학회지 Vol.38 No.1
We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca++([Ca++]i) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100mg/ml/Kg/day) or DHA(16mg/ml/Kg/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of [Ca++]i under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of [Ca++]i under ischemia by N2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca++ concentration.
-
Eicosanoids가 뇌허혈증 흰쥐의 에너지대사 및 Ca^++이동에 미치는 영향
한현정,이용규,신정희,윤재순 梨花女子大學校 藥學硏究所 1994 藥學硏究論文集 Vol.- No.4
We studied the effect of eicosanoids on the content of energy metabolites and the intrasynaptosomal Ca^++ (〔Ca^++〕_1) concentration in cerebral ischemic rats. An ischemic model was made by bilateral carotid artery ligation (BCAL) and by incubation of synaptosomes under aglycemic and N_2 gas bubbling condition. The content of ATP, creatine phosphate and glucose decreased at 15 minutes after BCAL while that of lactate increased in male Wistar rats. Oral administration of EPA(100 ㎎/㎖/㎏/day) or DHA(16 ㎎/㎖/㎏/day) for 6 weeks improved both the decreases and the increase of the cerebral energy metabolites. In addition, the increase of 〔Ca^++〕_1 under BACL was suppressed by EPA or DHA treatment. When the both Wistar rats and SHR were administered orally with EPA or DHA for 6 weeks, the effect on the increase of 〔Ca^++〕_1 under ischemia by N_2 gas bubbling were protected. From these results, it may be that EPA or DHA treatment were greatly contributed to preservation of ischemic cerebral energy metabolism and Ca^++ concentration.
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
