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한승석 ( Seung Seog Han ),윤우진 ( Woo Jin Yun ),정혜진 ( Hae Jin Jung ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.10
Background: Neuroimmunocutaneous system alteration can be responsible for the induction and maintenance of the inflammatory process of psoriasis. Objective: This study was carried out to examine the expression of Substance P (SP), calcitonin gene-related peptide (CGRP), somatostatin (SOM), neutral endopeptidase (NEP), SP receptor, and CGRP receptor in psoriatic lesions. Methods: A skin biopsy was obtained from 10 psoriatic patients and 10 normal control subjects. Confocal laser scanning microscopy was performed. Results: The SP and CGRP receptors consistently increased in psoriatic lesions, compared to the normal controls. Conclusion: The increased expression of neuropeptides and their receptors may be involved in the pathogenesis of psoriasis. (Korean J Dermatol 2006;44(10):1191~1194)