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성인발병 Still병의 피부 소견에 대한 임상 및 조직학적 고찰
한성협 ( Sung Hyub Han ),최광성 ( Gwang Seong Choi ),신정현 ( Jeonghyun Shin ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.4
Background: Adult-onset Still`s disease (AOSD), one of the causes of fever of unknown origin, is accompanied by skin rash. This is the reason why the clinical significance of skin lesions has been of interest. However, its skin manifestations and the histopathological findings are not clearly documented. Objective: This study aimed to identify characteristic clinical and histopathological features of skin manifestation of AOSD. Methods: We evaluated the medical records and histopathologic slides of five patients who had been diagnosed with AOSD in the rheumatology department and referred to our department between 1996 and 2009. Results: An asymptomatic evanescent salmon colored macular rash was seen in three patients (60%). A persistent brown plaque was seen in two patients (40%). Histopathologically, superficial perivascular infiltrates of neutrophils and lymphocytes were observed in all patients (100%) and necrotic keratinocytes were observed in the upper epidermis in three patients (60%). Conclusion: In addition to typical Still`s rash, atypical cutaneous findings such as persistent plaque lesions were found in AOSD patients. The results of this study may help clinicians to diagnose this rare disease more easily. (Korean J Dermatol 2010;48(4):283~289)
한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),홍원규 ( Won Kyu Hong ),이현숙 ( Hyun Sook Lee ),신정현 ( Jeong Hyun Shin ),최광성 ( Kwang Seong Choi ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Metastatic cancer of the umbilicus is very rare and is called Sister Mary Joseph`s nodule. Metastasis to the umbilicus usually presents as diffuse spreading of primary cancer or recurrence after treatment of primary cancer, carries very poor prognosis, and is generally inoperable. However, umbilical metastasis presents rarely as a first sign of primary cancer and can lead to its diagnosis. The diagnosis is usually made with the histologic examination and the most common primary cancer is an adenocarcinoma of the stomach. We report a case of umbilical metastasis as a first sign of gastric cancer which leads to its diagnosis. This report emphasizes the need for careful evaluation of any umbilical lesion. (Korean J Dermatol 2008;46(8):1103~1107)
Short Report : Acromegaloid Facial Appearance Syndrome with Generalized Hypertrichosis Terminalis
방찬일 ( Chan Yl Bang ),한성협 ( Sung Hyub Han ),변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.2
Acromegaloid facial appearance (AFA) syndrome is a rare autosomal dominant disease, consisting of an acromegaloid face, a bulbous nose, and narrowing of the palpaebral fissure. In 1996, Irvin first reported a case of a combination of acromegaloid facial appearance syndrome and congenital hypertrichosis, and reported this case as a new disease of acromegaloid facial appearance with generalized hypertrichosis terminalis, which is differentiated from both AFA syndrome and congenital hypertrichosis/gingival hyperplasia. We report herein the first Korean case of acromegaloid facial appearance with generalized hypertrichosis terminalis. (Korean J Dermatol 2011; 49(2):184~187)
송희진 ( Hee Jin Song ),한성협 ( Sung Hyub Han ),홍원규 ( Won Kyu Hong ),이현숙 ( Hyun Suk Lee ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.4
Rheumatoid neutrophilic dermatitis (RND) is a rare distinctive complication of rheumatoid arthritis (RA). Clinically, RND is characterized by slightly tender erythematous patches and papules, often associated with vesicles or pustules, which are symmetrically distributed on the extensor surfaces of the extremities. Histopathological findings revealed a dermal neutrophilic infiltration with leukocytoclasia without vasculitis. We report a case of rheumatoid neutrophilic dermatitis associated with seronegative RA. (Korean J Dermatol 2008;46(4):514~516)
에이퍼트 증후군에서 Isotretinoin로 치료한 난치성 여드름 1예
변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),양보희 ( Bo Hee Yang ),송희진 ( Hee Jin Song ),이현숙 ( Hyeon Sook Lee ),이승규 ( Seung Gyu Lee ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 大韓皮膚科學會 2009 大韓皮膚科學會誌 Vol.47 No.10
Apert syndrome is a rare genetic craniofacial disorder associated with premature fusion of multiple cranial sutures and syndactyly. It is caused by mutation in the fibroblast growth factor receptor 2 genes. The clinical findings are characterized by the typical dysmorphic facial features, including hypertelorism, proptosis and cleft palate. Most of these patients have widespread, severe acne involving the face, chest, back and forearms during puberty and the acne is unresponsive to conventional treatments. We report here on a patient with the recalcitrant acne of Apert syndrome and the patient had failed to respond to conventional acne treatment, but the acne was successfully treated with isotretinoin. (Korean J Dermatol 2009;47(10):1196∼1198)
변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ),이현숙 ( Hyeon Sook Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.2
Malalignment of the toenail is a rare deformity that is characterized by lateral deviation of the nail plate with respect to the longitudinal axis of the distal phalanx. The condition may be congenital or acquired. The acquired forms of malalignment may result from trauma or surgical intervention. However, there are only a few reports that have focused on surgical treatment for this condition. We present here a case of a 24-year-old woman who had this nail problem for 1 year and she was successfully treated with the surgical approach. We also discuss the probable mechanism of iatrogenic malalignment. (Korean J Dermatol 2010;48(2):148∼151)
양보희 ( Bo Hee Yang ),방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),신정현 ( Jeong Hyun Shin ),최광성 ( Gwang Seong Choi ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.2
Acantholytic squamous cell carcinoma is a well-defined, rare variant of squamous cell carcinoma in which significant portions of the neoplastic tissue show, on microscopy, a pseudoglandular or tubular pattern. It usually presents in aged patients as an erythematous nodule with scales, crust, and ulceration on sun-exposed areas. Herein we report a case of acantholytic squamous cell carcinoma that occurred on the Rt 4th toeweb of a 70-year-old man. (Korean J Dermatol 2011; 49(2):195~197)
경구 Isotretinoin으로 빠른 호전을 보인 염증성표재성파종성한공각화증
양보희 ( Bo Hee Yang ),방찬일 ( Chan Yl Bang ),변지원 ( Ji Won Byun ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),인승균 ( Seung Gyun In ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Disseminated superficial porokeratosis is a keratinization disorder characterized by multiple brown, atrophic patches with sharply demarcated and hypertrophic ridges. Atypical cases of disseminated superficial porokeratosis with acute exacerbation accompanied by severe pruritus have been reported as eruptive pruritic papular porokeratosis or inflammatory disseminated superficial porokeratosis. We report a case of inflammatory disseminated superficial porokeratosis in a 53-year-old man who was successfully treated with oral isotretinoin.
변지원 ( Ji Won Byun ),양보희 ( Bo Hee Yang ),한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),이현숙 ( Hyeon Sook Lee ),최광성 ( Gwang Seong Choi ),신정현 ( Jeong Hyun Shin ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Pruritic urticarial papules and plaques of pregnancy (PUPPP), also known as a polymorphic eruption of pregnancy, is the most common dermatosis of pregnancy. Typically, PUPPP starts with erythema and urticarial papular eruption in the abdominal striae and may extend to the buttocks and thighs. It usually evolves in the third trimester and resolves rapidly in the postpartum. It is not usually recurrent in subsequent pregnancies. We report herein two patients with postpartum PUPPP. (Korean J Dermatol 2010;48(3):228~231)