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홍성표(Sung Pyo Hong),이선주(Sun Ju Lee),이영식(Young Sik Lee),이상인(Sang In Lee),한지숙(Jee Sook Hahn),고윤웅(Yun Woong Ko),한상순(Sang Soon Hahn),윤홍섭(Hong Sup Yoon),이삼열(Samuel Y . Lee) 대한내과학회 1989 대한내과학회지 Vol.36 No.4
N/A Spur cell anemia is intense hemolytic anemia associated with alcoholic liver cirrhosis characterized by spiculated erythrocytes due to a striking increase in cholesterol content and in cholesterol to phospholipid ratio. Several attempts including splenectomy, plasmapheresis and calcium antagonists, have been tried to correct this anemia. Presented here is a case of a 60-year-old man with alcoholic liver cirrhosis who revealed jaundice and severe hemolyic anemia. The peripheral blood smear demonstrated spurred erythrocytes which are caused by serum factor. The cross incubation test, that is, spur cells with normal serum and normal red blood cells with the patient's serum, revealed reversability of the spur cells. The benefits of plasmapheresis were equivocal, while a calcium antagonist, flunarizine, was administered with discernible benefits. The authors suggest that spur cell anemia should be suspected in alcoholic liver cirrhosis with severe jaundice and anemia refractory to transfusion and that the calcium antagonist, flunarizine, is useful to treat it.