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Ciprofloxacin에 대한 집중 약물이상반응 모니터링
정선회,한동신,박경호,손인자,박병주,약물이상반응모니터링소위원회 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Ciprofloxacin has been associated with various adverse drug reaction such as headache, skin rash, nausea, vomiting, diarrhea and abdominal pain. A 60-year-old female developed skin rash, itching, urticaria following the line of vein in injection site. After cessation of the infusion, these symptoms disappeared soon. Because there were three more patients who experienced these symptoms, intensive monitoring for evaluating this phenomenon more thoroughly. From July 11, 2002 to September 6, 2002, Seoul National University Hospital Adverse Drug Reaction SNUH ADR) Monitoring Subcommittee conducted intensive monitoring for all patients prescribed ciprofloxacin and then we identified 27 cases of adverse drug reactions among 88 patients during the monitoring period. The incidence of ciprofloxacin was 30.7 per 100 patients, 0.36 per 100 drug prescriptions. The contents of adverse drug reaction were skin rash, itching, urticaria, nausea, vomiting, dizziness and general weakness. Dose of ciprofloxacin was 200㎎/100㎎.bag and the Lot. No. were 2011~2016. The administration sites were mostly dorsum of the hand or forearm. The incidence of the adverse drug reactions was not related to the infusion rate of ciprofloxacin, but was less frequent when the anticubital vein was used for infusion than the smaller peripheral veins were used.