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공동정호(共同井戶)의 대장균군조사(大腸菌群調査)에 관(關)한 연구(硏究)
한규송,Han, Kyu-Song 대한예방의학회 1974 Journal of Preventive Medicine and Public Health Vol.7 No.1
A study was carried out for the purpose of grasping the status of bacteriological contamination of the public wells in Iri city, during the period from 1 to 15 August, 1974. Coliform groups were detected by membrane filter method and physical conditions of the wells were checked. As results of this study, following conclusion were obtained. 1. The households which used the piped water occupied 70.8 per cent (11,907 households) out of total householdsir Iri city. 2. Temperature of the well water was 38 out of 50 samples (72.0%) with 12.1 to $16.0^{\circ}C$ and 9 wells with 10.1 to $12.0^{\circ}C$. 3. The pH values range of the well water was 6.0 to 7.9, 11 cases or 22,0 per cent less than 6.5 and 8 cases or 16.0 per cent more than 7.5. 4. The residual chlorine was found at 15 samples (30.0%) contained 0.1 to 0.5ppm, 9 samples (18.0%), 0.6 to 1.0 ppm after 24 houres of chlorination. 5. Coliform groups were found at 49 out of 50 samples (98.0%) before chlorination when 100ml well waters was tested by membrane filter technique and 15 wells(30.0%) were potable for drinking within 24 houres after chlorination. 6. Coliform groups positves were 23 out of 26 samples (88.5%) with no residual chlorine, 12 out of 16 samples (80.0%) with 0.1 to 0.5ppm and none out of 9 with 0.6 to 1.0ppm.
剔出 白鼠 心臟에서 Norepinephrine效果에 미치는 Diphenhydramine의 影響
문보영,한규송,곽용근,조규박 의과학연구소 1988 全北醫大論文集 Vol.12 No.4
Influences of diphenhydramine on the contractile response of isolated rat auricle to norepinephrine were studied in order to clarify the mechanisms of depressant and stimulant actions of diphenhydramine. 1. Large dose of diphenhydramine(10μM) potentiated the contractile action of norepinephrine but small dose of diphenhydramine suppressed the contractile action of norepinephrine. 2. Cocaine did not affect, the stimulant action of diphenhydramine, but reversed the depressant action of this drug. 3. Ouabain did not affect the excitory and inhibitory action of diphenhydramine. 4. Verapamil did not change the excitory and inhibitory action of diphenhydramine. From the above results, it has appeared that diphenhydramine has stimulant ant depressant action on the contractile action of norepinephrine, and it is suggested that the potentiation of norepinephrine action by diphenhydramine is due to inhibition of amine pump, but the inhibition of norepinephrine action by diphenhydramine is not related to modification of amine pump or Ca flux.
剔出 家兎 腸片에서 5-Hydroxytryptamine 筋收縮效果에 對한 硏究
황호용,한규송,곽용근,조규박 의과학연구소 1988 全北醫大論文集 Vol.12 No.4
To investigate the mechanism of contractile action of 5-hydroxytryptamine(5-HT) on the isolated intestinal smooth muscle preparation of rabbit, the influence of cyproheptadine, atropine, hexamethonium, morphine and hemicholinium treatment on the action of 5-HT were studied in this experiment. Results obtained from this experiment were summerized as follows : 1. 5-HT caused contractile response of isolated intestinal smooth muscle in dose-dependent manner. 2. In the intestinal preparation of saline treated rabbit, contractile action of 5-HT was inhibited by cyproheptadine, atropine or morphine, but not influenced by hexamehonium. 3. In the hemicholinium-pretreated preparations, the contractile response of intestinal smooth muscle was significantly inhibited by cyproheptadine, but did not inhibited by atropine or morphine. And also, hexamethonium did not influenced on the action of 5-HT as in the preparation of saline-treated rabbit. These results suggest that there are two mechanisms responsible for contractile action of 5-HT in the isolated rabbit intestinal smooth muscle preparation. One is the 5-HT receptor on the smooth muscle(possibly D receptor), and the other is the receptor on the parasympathetic ganglia which different from the hexamethonium-sensitive sites. 가토 회장 평활근 표본에서 5-hydroxytryptamine의 약리작용에 대한 지견을 얻고자 정상 및 hemicholi-nium 처리 가토의 회장편에서 5-hydroxytryptamine의 수축효과에 대한 cyproheptadine, atropine, hexame-thonium 및 morphine의 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. 수조내 5hydroxytryptamine은 가토 회장 평활 근편을 용량에 비례하여 수축시켰다. 2. 정상 가토의 회장편에서 5-hydroxytryptamine의 평활근의 수축작용은 cyproheptadine, atropine 및 morphine에 의해 감약되었으며, hexamethonium에 의해서는 영향받지 않았다. 3. hemicholinium 처리 가토의 회장편에서 5-hydroxytryptamine의 평활근편 수축작용은 cyproheptadine에 의해 현저히 억제되었으며 atropine, hexamethonium 그리고 morphine에 의해서는 영향받지 않았다. 이상의 실험성적은 적출 가토 회장 평활근에 있어서 5-hydroxytryptamine의 근편수축작용은 평활근에 있는 5-HT 수용체와 말초 부교감신경에 연계된 신경절에 존재하는 수용체 두가지의 작용점에 공히 작용하여 초래되며 이 신경절은 hexamethonium 민감부위와는 다른 것으로 사료된다.
白鼠에서 Morphine의 鎭痛效果와 그 耐性發現에 미치는 Vasopressin의 影響
허광열,한규송,김기원,채수완,조규박 의과학연구소 1991 全北醫大論文集 Vol.15 No.3
Morphine and its derivatives are still the most widely used drugs for the relief of pain in modrate to severe intensity. However, development of tolerance to many of their pharmacoligical actions, particularly to the analgesia has limited its value of use. Recentlt, there are mant evidenced that it suggests the close relationship between de velopment of tolerance. Therefore, in this stidt, the influence of arginine vasopressin and its major metavolite AVPOsvl in-the debelopment of tolerancr to the analgrsic rffect of thr drug were examined in the ret. AVP produced significant analgesia in the rat. But the AVP Meta bolite, could not induce ant changes in the respinse to thernal stimuli of the rat. This analgesic effect of AVP was not affected by nalaxone but severely diminished by V1 vasopressin recrptor antagonist, Both of thesepeptide and its metabolite did not influencd the analgesic effict of morphine. Significant tolerance to analgesic effect of morphine was induced by repeated injection of morphine at 3rd day from the beginning of the injection, This development of tolerance to analgesic effect of morphine was not affected by small dose of AVP but facilitated by fairly large dose of AVP in its timing of development and in degree of tolerance. Though the small dose of have no influence on the development of tolerance to analgesic effect of morphine, small dose of 1μg/kg of restored the analgesic effect of morphine to its potency of control value. These results indicate that AVP could produce a analgesic action that mediate not by opioid transmission but by vasopressin receptor, certainly V1. And also, it is suggested that vasopressin and its surrogates could greatly influence the development of tolerance to analgesic effect of morphine.
剔出 白鼠Vas Deferens에서 Acetylcholine 效果에 미치는 Morphine의 影響
조규박,은홍배,한규송 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.1
Effect of acetylcholine (ACh) on cotractile force of isolate vas deferens in control and chronic morphine-treated rat was investigated in this experiment. Preparations were applied with field stimulation(0.1 Hz. 10 msec of duration and 100 volts). 1. ED_50 and maximal response of control preparation to ACh were 8.3 ± 0.6 μM and 1736.8±112.7mg/10mg wet weight respectively. 2. In chronic morphine-treated preparation, ED_50 of ACh(4.5±0.4μM) was significantly reduced, whereas maximal response (1946.8±132.2mg/10mg wet weight) was slightly increased. 3. In these preparations, dose of ACh in the presence of atropine was highly increased. 4. pA2 value(affinity index of antagonist) of the chronic morphine-treated group was higher than that of control group. From the above results, it is suggested that development of acetylcholine supersensitivity by chronic morphine treatment is due to increase of muscarinic receptor affinity and partly due to increase of responsibility of the preparation to acetylcholine.
白鼠의 腦內 Opiate Receptor 日中 變動에 미치는 Scopolamine의 影響
마기환,고명규,김기원,조규박,한규송 전북대학교 의과학연구소 1986 全北醫大論文集 Vol.10 No.4
To investigate the influence of scopolamine on the diurnal variations of opiate receptor binding, the amount of specifically bound(3H)-morphine and β-endorphin were measured in the midbrain of rat at 4-hr intervals in a day. Animals were housed and adapted to a controlled cycle of either 12-hr light, 12-hr dark, or 240hr constant darkness. After 3 weeks of adaptation, vehicle or scopolamine(10mg/kg/day) or methscopolamine was administered intraperitoneally twice a day for 2 weeks. Highly significant rhythms of opiate receptor binding was found with peak at 22:00-hr and 06:00-hr in control group. Even in the absence of time cues these circadian rhythms persisted with peak at 02:00-hr and 14:00-hr and the rhythms were highly modified with respect to the wave forms as well as to the timing of peak and nadir. In the scopolamine-treated group, these diurnal rhythms were also modified in shape, phase and amplitude, as well as in timing of peak and nadir, In this group, 24-hr mean of opiate receptor binding was significantly increased and immunoreactive β-endorphin content was significantly decreased. But in the methscopolamine-treated group, 24-hr mean of maximum(3H)-morphine binding, β-endorphin content or other characteristics of circadian rhythm were not changed. However, Kd values, affinity index of receptors, were not changed in all experimental groups, indicating that the differences in binding were due not to changes in affinity but to changes in the number of binding sites. Statistical analysis of regression lines revealed a close inverse correlation between change of both receptor binding and β-endorphin content. These results indicate that scopolamine may affect the diurnal rhythm of opiate receptors by changing β-endorphin content and may influence the action of morphine by changing the number of opiate receptor in central nervous system.