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하신우,이현제,조애신,황성일,이학종 대한초음파의학회 2020 ULTRASONOGRAPHY Vol.39 No.1
Purpose: The purpose of this study was to evaluate the ability of contrast-enhanced ultrasonography (CEUS) with microbubbles to detect metastatic lymph nodes (LNs) for treatment planning and prognosis. Methods: For the metastatic LN model, ground VX2 tumor tissues were injected subcutaneously in 12 rabbits, just below the right hind limb. The rabbits were classified into three groups based on the LN area: group A (n=4, >1.9 cm2), group B (n=4, 1-1.9 cm2), and group C (n=4, <1 cm2). The LNs were monitored on CEUS for 10 seconds after injecting 2.5 mL of microbubbles. The percent area of metastatic LNs was calculated on pathologic images and compared with CEUS images. Results: In group A, the mean percent area of metastasis was 40.7%±19.4%. In all cases of metastasis, round-shaped perfusion defects were clearly observed in CEUS images. The metastatic areas were strongly correlated with pathologic findings. The mean percent area in group B was 21.5%±14.4%. The CEUS findings showed multiple nodular perfusion defects, clearly revealing the metastatic areas. In group B, the CEUS and pathologic findings were concordant for three of the four cases. The mean percent area in group C was 9.1%±6.4%. However, in this group, CEUS only detected a small perfusion defect in one case. Conclusion: CEUS has the potential to depict characteristic imaging features of metastatic LNs but still has limitations in early detection.
유방암 동물모델에서의 저강도 집속초음파를 이용한 마이크로버블 및 마이크로버블-나노물질 복합체 기반 항암제 전달 효율 검증
백희규,하신우,허형규,정병진,한문,문형원,김상균,이학종,박주영 대한의용생체공학회 2019 의공학회지 Vol.40 No.2
Ultrasound sonication along with microbubble (MB) could enhance drug delivery to promote the absorption of anticancer drugs into cancers in a noninvasive and targeted manners. In this study, we verify the acute drug delivery enhancement (within an hour) of two representative focused ultrasound driven drug delivery enhancement methods (MB and Doxorubicin-coated Nanoparticle complex (MB-NP) based). Experiments were conducted using in vivo mouse model with MDA-MB-231 breast cancer cell line. Ultrasound generated by single-element 1 MHz focused ultrasound transducer was delivered in pulsed sonication consisted of 0.125 msec bursts at a pulse repetition frequency of 2 Hz for 20 seconds without a significant increase in local temperature (less than 0.1oC) or hemorrhage. Doxorubicin concentrations in tumors were improved by 1.97 times in the case of MB-NP, and 1.98 times by using Doxorubicin and MB separately. These results indicate anticancer drug delivery based on MB and MB-NP can sig-nificantly improve the effect of anticancer drugs delivered to tumors in a short time period by using low-intensity focused ultrasound.
류승진,Eric Arifin,하신우,이진규 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.10
A highly sensitive on-site colorimetric forensic sensor has been developed for the quantitative detection of hydrogen sulfide and ammonia gases. The sensor consists of metal-ion-modified silica-gel powders placed in a glass tube. The powder color changes upon reaction with toxic hydrogen sulfide and ammonia gases. It is capable of easily detecting toxic gases in the concentration range between 100 ppm, which is considered as immediately dangerous to life and health, and 3000 ppm, which may cause death, by using a glass tube with an inner diameter of 3 mm. As the sensor reported here is insensitive to environmental conditions such as temperature or humidity, and is featured by simplicity, fast response, high sensitivity, and easily understandable results based on absolute affirmative/negative response, it is expected to be effectively used for on-site applications such as testing the existence of toxic gases in confined working and industrial spaces.
류승진,Eric Arifin,하신우,이진규 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.10
Immensely sensitive, accurate, and simple on-site colorimetric sensor has been developed for the quantitative detection of the sulfide ion in human blood plasma. The colorimetric sensor consists of lead-ion-modified silica-gel powders placed in a glass tube. The powder color changes upon reaction with sulfide ions in blood plasma. It is capable of easily detecting toxic sulfide ion by using a glass tube with an inner diameter of 3 mm. By employing the type of colorimetric sensor to a blood sample, it is possible to detect the sulfide ion with a concentration limit of 0.1 ppm and excellent reproducibility, thus making it superior to conventional analysis methods that need multiple preparation processes and various sophisticated instruments. Since the sensor reported here is insensitive to environmental conditions such as temperature or humidity, and is featured by simplicity, fast response, high sensitivity, and easily understandable results based on absolute affirmative/negative response, it is expected to be effectively used for on-site applications such as detecting poisonous ions in blood samples.