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융모종양에 대한 약물치료의 고찰 - Methotrexate 저항성을 중심으로
김두상(DS Kim),표지수(JS Pyun),김효숙(HS Kim) 대한산부인과학회 1967 Obstetrics & Gynecology Science Vol.10 No.3
Methotrexate treatments were done for 4 cases of metastatic choriocarcinoma and one case of chorioa- denoma destruens, with the result that the complete clinical healing was gained in one, while in 4 the resistance to methotrexate treatment developed. The followings are the summary of the result: 1)It seems that delayed initiation of treatment is followed with more liable resistance formation. 2)Effect of methotrexate was more pronounced on the vaginal metastatic growth than the pulmonary metastasis. The vaginal new growth could not be observed even after the resistance developed, whereas in the lung new growth or exacerbation of the old tumor could be observed. 3)The repeated cures or increments of the durg were not effective to reduce the resistance to meth- otrexate. Review of the literature and athor`s own clinical experience showed taht treatment in meth- otrexate-resistant cases should be switched on other anticarcinogenic agent. 4)Formation of resistance to methotrexate can reasonably be judged by Friedman rabbit unit, when the unit remains unchanged even after 2 cycle treatment of methotrexate or the suppressed unit shows increase with cessation of treatment or even under methotrexate regimen.
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