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배의 메탄올 추출물이 마우스의 비장세포 증식능과 Cytokine 생성능에 미치는 영향
황유경(Yoo-Kyung Hwang),표명윤(Myung-Yun Pyo) 대한약학회 2005 약학회지 Vol.49 No.1
This study was performed to investigate the potential of pear (Pyrus pyrifolia) as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokines (IFN-γ, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 ㎎/㎖) of pear methanol extracts (P-M) without mitogens, splenocytes proliferation (SP) was significantly increased. Also, SP to mitogens, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly increased by P-M when compared with controls. When splenocytes were cultured with P-M in the presence of Con A, cytokine (IFN-γ, IL-4) levels in culture supernatant were significantly enhanced in a dose-dependent manner except 2.5 ㎎/㎖ when compared with control group. Therefore, our study suggest that the pear has the potential of being an immune-modulating functional food.
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배양상황버섯 자실체의 승홍투여로 유도된 횐쥐 신기능에 미치는 영향
양기숙(Ki Sook Yang),정은주(Eun Joo Jung),표명윤(Myung Yun Pyo) 대한약학회 2002 약학회지 Vol.46 No.3
Phellinu linteus (Hymenocaetaceae) is a member of Basidiomycotinae, which has been used for the treatment of gastric cancer, Non-insulin-dependent diabetes mellitus, diarrhea, and menstrual irregularity: To investigate the diuretic action of Phellinu linteus, urinary volume, serum parameters and urinary electrolytes in HgCl2- induced acute renal failure rats in vivo were measured. The results showed that its MeOH extract produced significant increases on urinary volume, sodium and potassium excretion, and revealed lowering effects of the abnormally elevated BUN, creatinine and uric acid value in acute renal failure rats.
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Cisplatin이 1차 감작된 마우스의 IgM 용혈반 형성 세포수와 임파구 증식능에 미치는 영향
표명윤,강명옥,윤희은,주은영 숙명여자대학교 약학연구소 1996 약학논문집-숙명여자대학교 Vol.12 No.-
The effects of cisplatin on the IgM plaque forming cells and the lymphocyte proliferation in primarily sensitized mice were investigated. Cisplatin was i.p. injected with a single low does (0.825, 1.65, 3.3mg/kg, which is 5, 10, 20% of LD_50) to mice. The splenic IgM antibody plaque forming cell (PEC) was assayed after ICR mice had been treated in vivo with a combination of three different doses of Cisplatin at different time (day-2, day+2) plus SRBC(day 0). IgM PFC was significantly increased when drug was injected prior to immunization with SRBC, but it was decreased when administered after SRBC antigen. Splenocytes from mice injected with Cisplation(1.65, 3.3mg/kg) on the 2nd day before the test day were cultured with Con A and LPS. The splenocyte proliferation to Con A mitogen was slightly increased, but to LPS was significantly and markedly increased. It was found that Cisplatin at low dose showed either immunosuppression or immunostimulation, depending on the time of drug-application in relation to antigenic treatment.
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한순영,박귀례,홍진태,박기숙,김형식,오세동,최윤진,표명윤,장성재 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
Azole계 화학물질중 담배, 담배연기, 커피향등에 포함된 성분으로 보고된 benzothiazole유도체, benzoxanolem유초체, carbazole등의 최기형성을 in viro에서 검색하고, 같이 섭취하기 쉬운 알코올과 병용할 때 태자에 미치는 영향을 알아보고자 하였다.외부물질에 의한 배지의 신체 전반적 성장 발달에 대한 영향과 기형유발릉ㄹ 관찰할 수 있는 착상후 배자배양법을 사용, 임신 9.5일령의Wistar 흰쥐의착상우 배자에실험무질을 처리하고 48시간 배양한 후 형태 이상 유 ·무를 검색하고, 배자 각 기관의 성장 및 발달을 Van Maele-Fabry법에 따라 관찰하고 단백질함량을 측정 하였다. Benzothiazole (10-"~10-'M), 2-aminobenzothiaBole (10-"~5 f 10-"M), thiazole (10-"~10-'M), 2,5-dimethylbenzoxazole (10-"~10-"M), carbaBole (10-"~10-'M) 처리애 의하여 시험물질에 따라 짤현 부위 및 정로의 차이는 있으나 배자의 탈달 띤 성장의 지연을 유발하였는데, beRzothi,azole은 otic system, optic system 및 semite발달에, 2-aminobenzothiazole은 yolk sac diameter, head length, yotlt sac circulatory system에,thiazole은 yolk sac circulatory system, midbrain, otic system, optic system 및 forelimbfl , 2, S-djmethylbenzoxazole은 otic system, optic system 및 midbrain 발달에 , carbazole은 뇌발달에 특히 영향을 주었으며, t얀리 score의 유의적인 감소와 꼬리부분의 형태이상이 공통적으로 관찰되었다. Ethanol 처레로 심장, 뇌,otic, opt곯 3ystem, mandibular process 등의 발달에 영항을 미쳤고, 착상후 배자에 alcohol과 azole화합물을 복합처리할 메에 배자 발달 및 실장 지연의 심화경향이 관찰되었다. 따라서 담배, 커피등께 함유된 azole화합물의 양이 미량플지라도 배자독성 및 최기형성의 가능성과 알코올과 동시에 섭취할 때 배자독성증가의 가능성을 배제할 수는 없는 것으로 생각된다. Tobacco and coffee contain many compounds including azole group compounds, but a tie iBformatioB is available iri thesingle or the combinati㉠n with ethrandcultured for 48 h with diiferent doses of asole compounds [bengothiaBole & carbaBole (10-"~10--aBOM), 2-amino-benzothiazole (10-"~5×10-"M), thiazole (10-"~ 10-"H[), 2,5-dimethylbenzoxaBole (10-'-10-'M)] alone or the combination with 0.3% ethanol. Morphologicat ct.anges were determined uader mi.croscope for evaluation of e81bryo deITelopment and scored by the method of Van Maele-Fabrf. Atl ofcompound tested caused significant reduction of total score and abnormal tail development. In addition,benzothiazote, thiazole aBd 2,5-dimethylbenzoxazole inhibited otic and optic development. Thiasole aad2-nminobenpothiazole also inhibited the development of yollt sac circulatory system, yolk sack and headvelopment. Ethanol also cauE,ed reduction of heart, brain, otic, optic a.nd mandibular developraent. The embryotoxicity by the combirlation:-treatment of azole and ethanol was much greater than those by eachchemical alone. These data 1:uggest that some of azole compounds pi·esented in tobacco or/and coffeearoma may cause embryotoxicity, and the addition of ethanol increased their toxicity in cultured rat em-bryos.
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