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판정훈,이민국,장문한,Liana N. Crowley,Brandy L. Le,이다슬,김태균,김다혜,이강욱,고성규,이진협,이석희,김재겸 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.7
This study aimed to determine the optimal combination of three anti-inflammatory materials [i.e., Cervus nippon Temminck (CT), Angelica gigas Nakai (AN), and Rehmannia glutinosa (RG)] for the strongest anti-inflammatory potential. Eighteen combinations of the three materials were tested in LPS-stimulated RAW264.7 cells via assessing nitric oxide (NO). The best combination from in vitro studies was administered to LPS-treated C57BL/6J mice for five days. Subsequently, plasma metabolites were profiled by bioinformatics analyses and validations. As results, 2, 20, and 50 µg/mL of CT, AN, and RG (TM) were the most effective combination suppressing inflammation. In mice, TM mitigated hepatic inflammatory markers. Similarly, the metabolomics indicated that TM may suppress NF-κB signaling pathway, thereby alleviating hepatic inflammation. TM also decreased systemic and hepatic pro-inflammatory cytokines. Collectively, we found the optimal combination of TM for mitigating inflammation; thus further studies on safety, mechanisms, and clinical models are warranted for human applications.
A Study on Anger Emotion in English and Chinese
판천시,임성출 미래영어영문학회 2016 영어영문학 Vol.21 No.4
The aim of this study is to compare the similarities and differences in the expression of anger as an emotion between English and Chinese. This paper examines the metaphorical linguistic expressions and conceptual metaphors so as to build a relationship between language and concept. In order to achieve this purpose, this study employs a comprehensive approach combining quantitative and qualitative analysis. It is shown that (ⅰ) the differences are more significant than the similarities between the two languages, which is reflected in the performance of words and collocations at the level of language on one hand, and in the selection of source domains, the manners of linguistic conduct, the productivity of conceptual metaphors, and the models of conceptualization at the level of concept on the other hand; (ⅱ) language to some extent restrictively influences concept, and concept places limits on the performance of language.