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- 저자 : 최진욱 ( Jin Uck Choi ) (검색결과 1 건)
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소아의 두경부 피부염 환자에서 Malassezia 특이항체가 갖는 의미
최진욱 ( Jin Uck Choi ),황영진 ( Young Jin Hwang ),황윤하 ( Yoon Ha Hwang ),김성원 ( Sung Won Kim ) 대한천식알레르기학회 2016 Allergy Asthma & Respiratory Disease Vol.4 No.1
Purpose: Even though Malassezia yeast may play an important role in the exacerbation of atopic dermatitis (AD), only a few studies of Malassezia infection have been conducted in children with AD. Thus, we compared each of clinical findings, including the severity of head and neck dermatitis and laboratory results depending on specific IgE against Malassezia furfur. Methods: This cross-sectional study was carried out on 121 children aged 3 months to 18 years between April and July of 2014. Retrospective data was collected using the medical records, and patients were divided into 2 groups according to the presence of Malassezia sensitization. Results: Specific IgE against Malassezia (group 1) was observed in 28 of all patients (23.1%). Group 1 children were at an older age (9.1±6.9 vs. 2.1±3.7, P<0.001). Group 1 children had a higher SCORing Atopic Dermatitis (SCORAD) index (46.4±21.0 ng/mL vs. 37.2±13.4 ng/mL, P=0.001), and total IgE (1,324.2±1,166.0 IU/mL vs. 209.5±532.5 IU/mL, P<0.001) compared to group 2 children (Malassezia-). In the group 1, the correlation between the Malassezia-specific IgE and 25-hydroxyvitamin D3 was negatively weak (r=?0.106) and not statistically significant (P=0.246). Furthermore, Malassezia-specific IgE and the SCORAD index (r=0.281, P=0.002) or total IgE (r=0.380, P<0.001) were positively correlated. Conclusion: The results of this study suggest that specific IgE against M. furfur may be helpful in assessing the severity of prepubertal children and early adolescents with AD involving the head and neck.
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