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양성, 전암성, 암성 표피종양에서의 p21, p27 and β-catenin 발현에 대한 분석
류려선,최종환,서재홍 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Analysis of p21, p27 and β-catenin protein expression in the non cancerous, precancerous and cancerous epidermal skin tumors. Background: The epidermal skin tumors encompass a wide range of non cancerous, precancerous and cancerous conditions. The pathogenesis of seborrheic keratosis, keratoacanthoma, actinic keratosis, Bowen's disease and squamous cell carcinoma is not well understood. Objectives: The purpose of this study was to investigate the expression of p21, p27 and β-catenin in this lesions. Methods: Immunoperoxidase staining methods were applied to analyze p21, p27 and β-catenin expression in a total of 61 cases, including 21 seborrheic keratosis, 9 keratoacanthoma, 8 actinic keratoses, 6 Bowen's diseases and 17 squamous cell carcinoma. p21 is thought to mediate p53 signaling, induced by a DNA-damaged status, to arrest the cell cycle, the mechanism that controls p21 expression has not been clearly elucidated yet. p27 is a member of cip/kip family of cydin-dependent kinase inhibitors, which include the p21, p27, and p57 protein, the p27 protein is present in quiescent cells are stimulated by growth factors, a decrease or an absence of p27 protein expression has been suggested to be a powerful negative prognostic marker in patients with various malignancies, including breast, colon, and esophageal cancers. Results: p21 was expressed in 85.7% (18/21) of seborrheic keratsis, 33.3% (3/9) of keratoacanthoma, 75% (6/8) of actinic keratosis, 33.3% (2/6) of Bowen's Disease and 76.5% (13/17) of squamous cell carcinoma An increased expression of p21 was found 85.7% (18/21) of seborrheic keratosis. p27 was expressed in 100% (21/21) of seborrheic keratosis, 11.1% (1/9)of keratoacanthoma, 25% (2/8) of actinic keratosis, 83.3% (5/6) of Bowen's disease and 82.4% (14/17) of squamous cell carcinoma An increased expression of p27 was found 100% (21/21) of seborrheic keratosis. β-catenin expressed in 100% (21/21) of seborrheic keratosis 100% (8/8) of actinin keratosis, 100% (9/9) of actinic keratosis, 83.3% (5/6) of Bowen's disease and 88.2% (15/17) of squamous cell carcinoma in conclusion. Expression for p21 are low in seborrheic keratosis, keratoacanthoma, actinic keratosis, Bowen's disease and squamous cell carcinoma. In the seborrheic keratosis, strong expression of the cyclin-dependent kinase inhibitor. Our results support that p21, p27 protein and β -catenin play a role in keratinocyte differentiation and tumorigenesis of skin lesion.
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자궁내막증 판별에 대한 표지자로 β-catenin에 대한 연구
최종환,류려선,서재홍 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Backgrounds: β-catenin, a member of the catenin family, is an adhesion molecule normally present in the sub-plasmalemmal cell membrane. It is abnormally transferred to the nuclei when the adenomatous polyposis coli pathway, on which it depends, is altered. Abnormal β-catenin expression is documented in fibromatosis, intestinal polyps and endometrial carcinoma. The diagnosis of endometriosis is usually straightforward. However, it may be difficult to distinguish between endometriosis and other entities when the epithelial component is scare. There is currently no other marker that helps support the diagnosis of endometriosis. Design: This study aimed at: (a) determining whether β-catenin can identify normal endometrial tissue (proliferative phases and secretory phases), and (b) Validating the potential utility of β-catenin in identifying the stroma and glands in endometriosis. In addition to 22 cases of normal endometrial tissue. We tested 46 cases of endometriosis using β-catenin antibody (clone 14, transduction Labs) via immunohistochemistry. Results: 43 out of 46 cases of endometriosis showed Co-expression of β-catenin on both the gland and storma (either nuclear or membranous pattern). In the remaining 3 cases, β-catenin's expression was only focal. The stroma in 21 out of 22 cases of normal endometrium was detected by β-catenin, showing either a membranous or nuclear signal. In only 1 case, the signal distribution was very focal. No of the internal negative control tissues (ovarian stroma, myometrium) showed any significant levels of β-catenin expression. Conclusion: This study shows that β-catenin can successfully detect the glandular and stromal components of endometriosis, with a striking contrast to surrounding tissue, resulting in a very 'clean' background. β-catenin, thus, has the potential of identifying these lesions in morphologically equivocal situations. The mechanisms of abnormal expression of β-catenin on the stroma of endometriosis is unclear, and warrants further investigations.
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