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경옥고의 생리활성 (Ⅱ) : 고혈당, 고혈압, 지구력 및 체중감소에 미치는 영향
황완균(Wan Kyunn Whang),오인세(In Se Oh),이숙희(Suk Hee Lee),최수부(Soo Bu Choi),김일혁(Il Hyuk Kim) 한국생약학회 1994 생약학회지 Vol.25 No.1
The studies were conducted to investigate the anti-diabetic activities on the hyperglycemia induced by streptozotocin in rats, anti-hypertensive activities in SHR, anti-fatigue and decrease of body weight activities in mice by Kyung Ok-Ko water extract and drink, which is a traditional preparation in Korea. 1. The blood glucose levels of streptozotocin-induced hyperglycemic rats were dosedependently decreased by administrations of various doses(300, 600, 1200 ㎎/㎏) of Kyung Ok-Ko water extract. Particularly, administration of 600, 1200Ing/kg were significantly shown to decrease glucose levels comparing with control group. 2. The serum total cholesterol levels of streptozotocin-induced hyperglycemic rats were dose-dependently decreased by administrations of various doses(300, 600, 1200 ㎎/㎏) of Kyung Ok-Ko water extract. Particularly, administration of 600, 1200 ㎎/㎏ were significantly shown to decrease total cholesterol levels comparing with control group. 3. The serum triglyceride levels of streptozotocin-induced hyperglycemic rats were dosedependently decreased by administrations of various doses(300, 600, 1200 ㎎/㎏) of Kyung Ok-Ko water extract. Particularly, administration of 600, 1200 ㎎/㎏ were significantly shown to decrease triglyceride levels comparing with control group. 4. The blood pressure in SHRs were dose-dependently lower descended by administration of Kyung Ok-Ko water extract 300, 600, and 1200 ㎎/㎏, respectively. The swimming time of Kyung Ok-Ko water extract (100, 200, 400 ㎎/㎏) and drink(0.7, 1.4, 2.1 ㎖/㎏) were significantly extended to all experimental group dose-dependantly. 6. The decrease of body weight of Kyung Ok-Ko water extract (100, 200, 400 ㎎/㎏) and drink(0.7, 1.4, 2.1 ㎖/㎏) were significantly evaluated dose-dependantly in all experimental group.
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