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옻나무 플라보노이드가 수컷 백서의 성행동에 미치는 영향
나천수(Chun Soo Na),최범락(Bum Rak Choi),추동환(Dong Wan Choo),최원일(Won Il Choi),김진범(Jin Bum Kim),김현정(Hyun Jung Kim),정연준(Yun Jun Chung),박영인(Young In Park),동미숙(Mi Sook Dong) 대한약학회 2005 약학회지 Vol.49 No.6
Rhus verniciflua Stokes (RVS) has been used as a food supplement and a traditional herbal medicine for a men's sexual enhancement. In this study, we prepared a flavonoid fraction (RWE) from a hot water extract of RVS and its influence on sexual behavior was studied in male rats which were orally administered varying doses of RWE for 2 weeks. All doeses of RWE stimulated sexual behavior in male rats such as reducing mounting latency and enhancing mount frequencies. However, intermission numbers were not changed and none of group can observe the ejaculation during behavioral testing time 5 min. Testosterone levels were increased about 0~53% and 92~164% by the treatment of RWE for 1 and 2 weeks, respectively. However, estrogen levels in male rats teded to decrease in a dose dependent manner of RWE. At the dose of RWE 200㎎/㎏, estrogen level was reduced to 77.5% and 70.3% of control after 1 and 2 weeks treatment. These findings suggest that the Rhus flavonoid fraction can stimulate the androgen-dependent male sexual behavior and it can applied to the material of functional food for enhancing the sexual function.
옻나무(Rhus verniciflua STOKES) Flavonoid 분획 투여가 정자생성 및 생식관련 장기에 미치는 영향
나천수(Chun-Soo Na),최범락(Bum-Rak Choi),추동완(Dong-Wan Choo),최원일(Won-Il Choi),김진범(Jin-Bum Kim),김현정(Hyun-Chung Kim),박영인(Young In Park),동미숙(Mi-Sook Dong) 한국독성학회 2005 Toxicological Research Vol.21 No.4
Rhus verniciflua Stokes (RVS) has been used as a food supplement and a traditional herbal medicine. In this study, we prepared various flavonoid fractions (RS, RW1, RW2 and RWE) from a hot water extract of RVS and their influence on male reproductive organs and spermatogenesis were studied in rats which were orally administered 200 ㎎/㎏ of them for 8 weeks. All experimental groups did not show any significant changes in body weight and blood clinical chemistry for liver function. Plasma testosterone level was elevated about 3.7, 5.2 and 6.3 folds in RW1, RW2 and RWE groups, respectively. The weights of testes and epididymides tended to increase slightly without the statistical significance in RW2 and RWE. The spermatozoon motility and epididymal sperm concentration were significantly increased (P < 0.05) in RWE and RW1, respectively, when compared to the control group. There was no significant difference in histology and apparent shape of testes and epididymides among the control and the experimental groups. Collectively, RWE showed effectively the elevation of plasma testosterone level, spermatozoon motility and the epididymal sperm concentration without the significant increase of testis and epididymides weights. When the component HPLC profile among the flavonoids fractions of RVS was compared, the ratio of components were only different. These findings suggest that the Rhus flavonoid fraction, particularly RWE, can stimulate the androgen-dependent male sexual function and it can be applied to the material of functional food for enhancing the sexual function.