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권경진 ( Kyoung Jin Kwon ),김도정 ( Do Jung Kim ),김상섭 ( Sang Seop Kim ),최유빈 ( Yu Bin Choi ),김미정 ( Mi Jeong Kim ),최명신 ( Myeong Sin Choi ),최보경 ( Bo Kyung Choi ),김동섭 ( Dong Sup Kim ) 대한화장품학회 2010 대한화장품학회지 Vol.36 No.3
탈모 방지의 목적으로 사용되는 양모제는 현재 우리나라에서 의약외품이며 약사법으로 관리되고 있다. 최근 탈모에 대한 사회적 관심이 증가하면서 양모제에 대한 수요도 증가하고 있는 실정이지만 양모제는 생약추출물, 비타민류, 보존제 등 다양한 종류의 성분이 혼합되어 있어 분석이 쉽지 않다. 본 연구에서는 양모제의 주성분으로 많이 쓰이는 니코틴산아미드, 덱스판테놀, 살리실산, 초산토코페롤, 니코틴산벤질에 대한 동시분석법을 확립하고자 하였다. 시판 중인 양모제를 구입하여 C18 컬럼, 아세토니트릴과 인산염완충액을 용매로 사용하여 HPLC로 분석하였다. 검출은 자외부흡광광도계를 이용하여 220, 270, 300 nm 파장에서 분석하였으며, 12.5 ∼ 800 μg/mL 농도범위에서 검량선을 작성하였다. 회수율은 액상기제의 경우 97.3 ∼ 103.5 % (상대표준편차 0.9 ∼ 2.8 %), 샴푸기제의 경우 101.9 ∼ 115.9 % (상대표준편차 0.7 ∼ 7.7 %)로 양호한 결과를 나타냈다. 시판중인 검체의 함량 시험결과 기준에 적합하였으며, 본 분석법을 이용하여 품질관리 및 추후 양모제 개발에 유용하게 활용함으로써 우수한 품질의 양모제 유통에 크게 기여할 것으로 기대된다. The hair nourisher products are used for prevention of hair loss and classified as quasi-drug in Korea. As concerns about hair loss has been increased, the demand for hair nourisher products has been growing. It is difficult to analyze their main ingredients because they contain various ingredients including natural plant extracts, vitamins, preservatives and exfoliators. The purpose of this study was to develop and validate simultaneous analytical methods of active ingredients in hair nourisher products such as nicotinamide, tocopherol, salicylic acid, dexpanthenol and benzyl nicotinate by HPLC. The active ingredients were separated on a C18 column by using acetonitrile/ phosphate buffer as a mobile phase, and detected at UV 220, 270 and 300 nm. The calibration curve showed linearity in the range of 12.5 ∼ 800 μg/mL and the recoveries were 97.3 ∼ 103.5 % (RSD 0.9 ∼ 2.8 %) in liquid matrix and 101.9 ∼ 115.9 % (RSD 0.7 ∼ 7.7 %) in shampoo matrix. Validated method was applied to hair nourisher products obtained from distribution market. Fortunately, all samples met their criteria. This study might be expected to provide the method for determining active ingredients in hair nourisher products and lead to promote a rapid market entry.
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박소민,최명신,한규원,김길수 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15
PGE₁is an endogenous substance of potent vasodialator as well as inhibitor of platelet aggregation. It has been used therapeutically in peripheral arterial occlusive disease and impotence. Intracavernous injection of PGE₁ for erectile dysfunction has been established for several years as a treatment option for erectile dysfunction of diverse etiologies, but this mode of administration is limited by penile discomfort, pain at the injection site, inconvenience and noncompliance. As the matter of worse, the β-hydroxy moiety of PGE₁is extremely susceptile to dehydration in solution to give inactive PGA₁ and PGB₁. For the improvement of stability, rapid absorption at action site and the convenience of application, PGE₁was formulated as urethral suppositories of three types of formulations, such as PEG, witepsol, and the mixture of PEG and witepsol. The stability test of PGE₁and the release test in urinary suppositories were performed. Futhermore, the effect fo enhancers and vehicle composition on the penetration of PGE₁through excised rat skin was evaluated by permeability coefficient and enhancement ratio.
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