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김종길,천자성 大韓神經精神醫學會 1989 신경정신의학 Vol.28 No.5
This study was conducted to determine reliable biochemical and hematologic markers of the Korean alcoholics. A comprehensive set of laboratory information was acquired from 44 alcoholics,33 non-alcoholic liver disease patients and 36 social drinkers. Then the data of the alcoholics were compared to those of the other groups. The results were as follows ; 1) The mean values of gamma-glutamyltranspeptidase(GGT), mean corpuscuhar volume(MCV) and mean corpuscular hemoglobin(MCH) were above normal in the alcoholics, and significantly differentiated the alcoholics from the non-alcoholic liver disease patients. 2) The mean values of aspartate aminotransferase(SGOT), alanine aminotransferase(SGPT), lactate dehydrogenase(LDHl), GGT and MCV were above normal in the alcoholics, and significantly differentiated the alcoholics from the social drinkers. The mean value of red blood cell count(RBC) was below normal in the alcoholics, and significantly differentiated the alcoholics from the social drinkers. 3) Both GGT and MCV significantly differentiated the alcoholics from the social drinkers, and the alcoholics from the non-alcoholic liver disease patients as well. Therefore, it seems that GGT and MCV can serve as biochemical and hematologic markers of alcoholism, and improve diagnostic objectivity.