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- 저자 : 천기태(Gi Tae Chun) (검색결과 1 건)
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전창호(Chang Ho Jeon),이창환(Chang Hwan Lee),송항용(Hang Young Song),천기태(Gi Tae Chun),권철(Chul Kwon),이수택(Soo Taik Lee),김대곤(Dae Ghon Kim),안득수(Duek Soo Ahn) 대한내과학회 1994 대한내과학회지 Vol.47 No.5
N/A Objectives: Decreased glomerular filtration rate, low urine output, sodium retention, and ascites formation associated with impaired water excretion and dilutional hyponatremia often complicate the course of patients with cirrhosis of the liver. Somatostatin, an agent that causes selective splanchnic arteriolar vasoconstriction and decreases portal and collateral blood flow and portal pressure, is widely used in cirrhotic patients for the treatment of acute vriceal bleeding and cirrhotic patients with ascites. We performed this study to evaluate the effect of somatostatin analogue on renal function of cirrhotic patients with hepatorenal syndrome. Methods: The effect of somatostatin analogue on renal function was investigated in 15 cirrhotic patients with hepatorenal syndrome with low urine output, low serum sodium, and increased serum creatinine. somatostatin analogue (octreotide) 50 ug was injected subcutaneously for 3 days. Results: The probability of hepatorenal syndrome occurrence was more common in viral hepatitis induced cirrhosis than alcoholic cirrhosis. In the patients with hepatorenal syndrome, octreotide induces a significant increase in urine volume (before injection 450±35.9 vs. 1st day 620±46.2, 2nd day 1190±160.9, 3rd day 896±141.4 ml/dl), a significant decrease urine osmolarity (before injection 526±63 vs. 1st day 445±69, 2nd day 430±56, 3rd day 438±61 mOsm/kg), and significant increase in free water clearance (before injection-0.4±0.3 vs.-lst day 0.5±0.1, 2nd day 0.6±0.2, 3rd day 0.5±0.1 ml/min). Conclusion: The effect of somatostatin might be attributed to an improvement of renal hemodynamics through splanchnic vasoconstriction in hepatorenal syndrome. It is concluded that somatostain may have a role in the treatment of the renal abnormalities complicating liver disease.
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