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채병문,김종문 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.3
The effect of taxol on the production of nitric oxide(NO) and reactive oxygen radicals(O₂^(-) and H₂O₂) and the function of phagocytic activity of murine microglial cells were investigated. Stimulated cells with taxol showed more phagocytic activity than the cells which were incubated with medium alone. Taxol-treated cells also showed increased production of such reactive oxigen radicals as superoxide and hydrogen peroxide measured by luminometer after stimulated with phorbol myristate acetate (PMA). Taxol alone had only being small effect on NO synthesis, whereas taxol in combination with rIFN-γ synergistically increased NO synthesis in a dose dependent manner. The production of NO by taxol plus rIFN-γ was reduced by such L-arginine analogues as N^(G)-mono-metyl-L-arginine monohydrate(N^(G)MMA), and N-amino-L-arginine (NAA) and arginase which decomposes L-arginine. Collectively, the data illustrate the potential for taxol to activate microglia-mediated anticancer mechanisms in the brain in addition to its better characterized effects on ovarian, breast, and lung cancer.
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교통성 뇌수종 환자에서 요추강 복막강간 도관술의 효능 및 예후 인자에 대한 분석
채병문,김태영,한병갑,김종문 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.9
The effect of lumboperitoneal(LP) shunt and the prognostic factors of 40 cases of communicating hydrocephalus confirmed by brain computerized tomography(CT) and/or magnetic resonance imaging(MRI) and radioisotope cisternography(RI) were analyzed. Possible prognostic factors such as disease entity, CT or MRI findings, and the type of radioisotope cisternography were compared to improvement of clinical status after LP shunt. The etiology of communicating hydrocephalus in the analyzed 40 cases included trauma in 13 cases(32.5%), subarachnoid hemorrhage(SAH) in 12 cases(30%), intracerebral hemorrhage(ICH) in 10 cases(25%), and idiopathic in 5 cases(12.5%). An overall clinical improvement after LP shunt was seen in 22 cases(55%). Howcver, in 17 cases of SAH and idiopathic group, improvement after LP shunt was seen in 13 cases(75%), indicating that LP shunt is more effective in SAH/idiopathic group than trauma/ICH group(p < 0.05). Many findings of brain CT/MRI such as Evan's index, periventricular low density, 3rd ventricular width, obliteration of cerebral sulci, rounding of frontal horn, and cortical atrophy were analyzed as prognostic factors. Except for the absence of cortical atrophy(P < 0.05), none of the factors were related to the patient's outcome. The type of abnormal RI cisternography findings(Type Ⅰ,Ⅱ,Ⅲ) also did not show any relationship with the effectiveness of LP shunt. These findings suggest that SAH/idiopathic group were more favorable candidates for LP shunt than trauma/ICH group, and that there are no reliable brain CT/MRl findings indicating a good prognosis after LP shunt except for the absence of cortical atrophy. RI cisternography findings are also not a reliable diagnostic tool in evaluating the indication of LP shunt in communicating hydrocephalus.
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