http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 진송효 (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
김성근,김영미,염정은,진송효,채규태,이성범 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.6
Rifampicin is a macrocyclic antibiotic which is used extensively for treatment against Mycobacterium tuberculosis and other mycobacterial infections. Recently, a number of studies have focused on the immune-regulatory effects of rifampicin. Therefore, we hypothesized that rifampicin may influence the TLR2 expression in LPS-activated RAW 264.7 cells. In this study, we determined that rifampicin suppresses LPS-induced TLR2 mRNA expression. The down-regulation of TLR2 expression coincided with decreased production of TNF-α. Since NF-κB is a major transcription factor that regulates genes for TLR2 and TNF-α, we examined the effect of rifampicin on the LPS-induced NF-κB activation. Rifampicin inhibited NF-κB DNA-binding activity in LPS-activated RAW 264.7 cells, while it did not affect IKKα/β activity. However, rifampicin slightly inhibited the nuclear translocation of NF-κB p65. In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-κB p65, suggesting pregnane X receptor interferes with NF-κB binding to DNA. Taken together, our results demonstrate that rifampicin inhibits LPS-induced TLR2 expression, at least in part, via the suppression of NF-κB DNA-binding activity in RAW 264.7 cells. Thus, the present results suggest that the rifampicin-mediated inhibition of TLR2 via the suppression of NF-κB DNA- binding activity may be a novel mechanism of the immune-suppressive effects of rifampicin.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
