http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 진선필 ( Seon Pil Jin ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Particulate Matter Penetrates into Barrier-Disrupted Skin in Vivo
진선필 ( Seon-pil Jin ),( Soyun Cho ) 한국피부장벽학회 2018 한국피부장벽학회지 Vol.20 No.2
In addition to the sunlight, the damaging effects of pollutants on human skin have been the subject of intense research recently. Particulate matter (PM) in air pollution is a mixture of particles suspended in the air. Major components of PM are metals, organic compounds, ions, and particle carbon core. Gases are also contained that are adsorbed onto the particles. Recently, PM has been reported to be associated with increased risks of skin diseases. It demonstrates that chronic traffic-related PM exposure is associated with premature skin aging, with 20% increase in pigment spots on the forehead and cheeks. In addition, literatures showed that pollutants may increase the incidence of atopic dermatitis in young people and aggravate their symptoms, particularly the itching sense, and may also be the cause of increased urinary ROS in the children with atopic dermatitis. These epidemiologic reports suggest that PM may penetrate the skin barrier to increase ROS, which aggravates skin inflammation. Since PM is a mixture of insoluble particles and soluble components such as gases or ions, PM might still induce harmful effects through soluble components, even though the particles cannot penetrate into the skin. Nevertheless, because there is no direct evidence whether particles can penetrate into the skin, we investigated if particles from locally collected PM penetrates into mice skin in vivo and if PM causes inflammation via ROS-dependent manner. Keratinocyte cytotoxicity increased in a dose-dependent manner by PM treatment. IL-8 and MMP-1 mRNA expression and protein levels were significantly increased compared to control by qPCR and ELISA, respectively. Cellular ROS production was increased by PM treatment, and antioxidant N-acetyl cysteine pretreatment prevented induction of inflammatory cytokines IL-8 and MMP-1. In PM-treated keratinocytes, electron-dense subcellular particles were observed by transmission electron microscopy. PM was observed inside hair follicles in both intact and barrier-disrupted skin in vivo. Additionally, intercellular penetration of PM was seen in the barrier-disrupted skin. Repeated PM application induced epidermal thickening and dermal inflammation with neutrophil infiltration. Finally, N-acetyl cysteine could ameliorate skin inflammation induced by PM application. In conclusion, PM penetrates into the barrier-disrupted skin, causing inflammation, demonstrating detrimental effects in the skin.
-
-
염꽃보라 ( Kkot Bora Yeom ),진선필 ( Seon Pil Jin ),최재우 ( Jae Woo Choi ),권순효 ( Soon Hyo Kwon ),윤상웅 ( Sang Woong Youn ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10
Seborrheic keratosis is one of the most common benign epithelial tumors, especially in elderly patients. Squamous cell carcinoma is the second most common malignant tumor of the skin. Despite the fact that both tumors are common, malignant transformation of seborrheic keratosis rarely occurs. Herein we report a case of squamous cell carcinoma arising in a patient with pre-existing seborrheic keratosis. (Korean J Dermatol 2011;49(10):923∼926)
-
Methyl 5-aminolaevulinic Acid 국소 광역동 요법을 이용한 광선각화증의 치료
박현선 ( Hyun Sun Park ),진선필 ( Seon Pil Jin ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.10
Background: Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizer, oxygen and a light source to induce selective targeted cell death. It is used for various skin conditions, including actinic keratosis (AK). Both 5-aminolevulinic acid and methyl aminolevulinic acid (MAL) are currently available as photosensitizers. Although there are several studies on the treatment of AK using 5-aminolevulinic acid-PDT in Korea, there are few studies on using MAL-PDT for the treatment of AK. Objective: The purpose of this study is to evaluate the efficacy and safety of MAL-PDT for the treatment of AK. Methods: We performed a retrospective study and reviewed 64 AK lesions from 28 patients who were treated by MAL-PDT between January 2008 and April 2010. The data was collected through the medical records, the clinical photographs and the biopsy specimens. Results: The patients were treated with either a single treatment or double treatments 1 week apart. The treatment results were assessed after 12 weeks. Overall, complete remission was achieved in 42/64 lesions (65.6%). Although a single treatment was effective for thin lesions, the complete response rates were significantly lower for the moderately thick and severely thick lesions (100% vs 71.3% vs 22.2%, respectively). Repeated treatment tended to improve the complete response rate of the severely thick lesions. A favorable cosmetic outcome was achieved and only tolerable local side effects were reported after MAL-PDT. The patients were followed up for an average period of 6 months and 4 lesions recurred. Conclusion: MAL-PDT is an effective and well-tolerated treatment option for thin and moderately thick AK. However, further study is required for determining the optimal regimen for thicker lesions and the long-term treatment results of MAL-PDT. (Korean J Dermatol 2010;48(10):837~843)
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
