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계피로부터 Malassezia 종에 대한 항균물질 분리 및 동정
엄지영(Ji-Young Um),진방민(Bang-Min Jin),조용권(Yong-Kweon Cho) 한국화장품미용학회 2020 한국화장품미용학회지 Vol.10 No.3
To overcome side effects of dandruff medications, many researches on natural anti-dandruff compounds are actively being conducted. Here, we tried to isolate and identify antifungal compounds against four Malassezia species (M. restricta, M. globosa, M. furfur, M. sympodialis) from Cinnamomoum cassia Blume. Cinnamomum cassia Blume was extracted with 80% (v/v) ethanol for 7 days. The extracts were purified by solvent fractionation, silica gel column chromatography and HPLC. The purified compound was identified for the active peak with 1H-NMR and <SUP>13</SUP>C-NMR. Among 5 solvent fractions, only hexane fraction (CHF) showed antifungal activity. The data showed that CHF has higher activity than that of Zinc pyrithione (ZPT) in M. furfur, and lower than that of ZPT in M. restricta, M. globosa and M. sympodialis. Thus, CHF has been further purified by silica gel column chromatography and Prep-HPLC. The analysis of 1H-NMR and <SUP>13</SUP>C-NMR revealed that structure of isolated compound is coumarin. Coumarin showed the antifungal activity of 11.5 mm, 10.1 mm, 14.2 mm and 19.8 mm for M. furfur, M. restricta, M. globosa and M. sympodialis, respectively. MIC50 values of coumarin were 79.09 μg/mL, 133.91 μg/mL, 63.41 μg/mL and 19.72 μg/mL for M. furfur, M. restricta, M. globosa and M. sympodialis, respectively. The anti-inflammatory activity of coumarin at concentrations of 0.013∼0.855 nM showed that coumarin inhibited nitric oxide production by 18∼22% in RAW 264.7 cell. These data suggest that Cinnamomum cassia Blume extracts and its isolated coumarin are good candidates for dandruff medications.
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쇠별꽃 메탄올추출물의 항산화능 및 B16F10 세포에서 광보호 효능
전근영 ( Geun Yeong Jeon ),진방민 ( Bang Min Jin ),조용권 ( Yong Kweon Cho ),김영철 ( Young Chul Kim ) 대한미용학회(구 대한미용과학회) 2021 대한미용학회지 Vol.17 No.2
The aim of the current study was to investigate the antioxidant ability of Stellaria aquatica L. methanol extract (SAME) and its photoprotection efficacy of B16F10 cells irradiated with UVA. Total polyphenol and flavonoid contents in SAME were estimated to be 284.4 TAE mg/g and 210.5 RE mg/g, respectively. At 1,000 μg/mL, the electron-donating ability of SAME was found to be 58.0% and its SC50 for free radical scavenging was 748.2 μg/ mL. The viabilities of B16F10 cells treated with SAME at 25 and 50 μg/mL were 87.7% and 73.1%, respectively. On the other hand, the viabilities of B16F10 cells treated with IBMX at 25 and 50 μg/mL were 81.3% and 76.1%, respectively. The maximum permissible levels for treating the B16F10 cells with SAME and IBMX were calculated to be 25 μg/mL. Irradiation with 5 and 10 mJ/㎠ UVA decreased the viabilities of the B16F10 cells by 21.6% and 25.1%, respectively, which, however, increased viabilities by 13.0% (p < 0.001) and 11.5% (p < 0.001), respectively on treatment with 25 μg/mL SAME. On the other hand, when 5 and 10 mJ/㎠ UVA-irradiated B16F10 cells was treated with 25 μg/mL IBMX, the viabilities increased by 8.7% (p < 0.05) and 4.7% (p < 0.01), respectively. These results suggest that SAME can be used as a natural cosmetic ingredient for photoprotection of melanocytes from UVA irradiation.
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B16F10 세포에서 쇠별꽃 메탄올추출물의 멜라닌 생성 촉진 효능
전근영 ( Geun Yeong Jeon ),진방민 ( Bang Min Jin ),조용권 ( Yong Kweon Cho ),김영철 ( Young Chul Kim ) 대한미용학회 2021 대한미용학회지 Vol.17 No.3
The present study investigated into the efficacy of Stellaria aquatica L. methanol extract (SAME) on melanin production and photoprotection in B16F10 cells irradiated with or without UVA and elucidated the associated molecular and cellular mechanisms. The melanin content of B16F10 cells treated with 25 μg/mL of SAME and 3-isobutyl-1-methylxanthine (IBMX) was found to increase by 18.0% and 37.2%, respectively. On the other hand, tyrosinase activities of B16F10 cells treated with 1,000 μg/mL of SAME and IBMX increased by 35.2% and 27.8%, respectively. Additionally, the levels of reactive oxygen species (ROS) in B16F10 cells irradiated with 5 mJ/㎠ UVA increased by 66.1% (p<0.001). By contrast, when 5 mJ/㎠ UVA-irradiated B16F10 cells were treated with 25 μg/ mL SAME and IBMX the ROS production decreased by 10.8% (p<0.001) and 10.4% (p<0.001), respectively. Taken together, the melanin production-promoting and photoprotective efficacy of SAME in B16F10 cells appeared to be mediated through an increase in tyrosinase activity and a decrease in ROS production in these cells.
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