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- 저자 : 주현영(Hyung Young Ju) (검색결과 1 건)
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Indomethacin 이 말기 신부전증 환자의 자율신경계 기능에 미치는 영향에 관한 연구
하성규(Sung Kyu Ha),한대석(Dae Suk Han),주현영(Hyung Young Ju),김형직(Hyung Jik Kim),구철회(Chul Hoe Koo),김문재(Moon Jae Kim),이호영(Ho Yung Lee) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A The authors studied autonomic nervous system fucntion in 63 patients with uremia and 56 normal control subjects. Among these, automonic nervous system function was evaluated in 11 normal control subjects, 18 hemodialysis patients and 6 CAPD patients before and after indomethacin administration. The results were as follow: 1) The valsalva ratio and heart rate variation ratio were significantly lower in CRF group than normal control group (p<0.05); however, there was no statistically significant differences among CRF patient group (p<0.l). 2) The change of diastoloic blood pressure after orthostasis was significantly lower in CRF group than normal control group (p<0.05). The heart rate was more rapid in normal cantrol group, hemoidalysis patients group and CAPD patient group than predialysis patient group (p<0.05). 3) The change of blood pressure after hand grip exercise was lower in predialysis (p<0.05), The degree of increase in heart rate was lower in predialysis patients than normal control group. 4) Although the valsalva ratio and heart rate variation ratio seem to improve after indomethacin administration, they were not statistically significanct (p<0.1), The change of heart rate in response to valsalva maneuver after indomethacin administration was not sign-ficiant (p<0.1). 5) The change in blood pr re and heart rate before and after indomethacin administration were not statistically significant (p>0.05). However, there was significant increase in systologic and diastolic blood pressure in CAFD patients with hand grip exercise after indomethacin administration (p<0.025). In summary, the function of ANS in patients with CRF was significantly reduced than the normal control group. Although, the function of ANS seemed to improve slightly after indomethacin administration in patients with CRF, the results were not satatistically significant, The prostaglandin has been proposed to play a role in ANS dysfunction. However, the results of this study does not seem to support this theory. Futher studies would be required in odrer to show the role of prostaglandin in ANS dysfunction in patients with CRF.
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