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      • 소염 효소제 Danzen의 임상적 관찰

        김인철,주상용,안긍섭,고용복,이용각 中央醫學社 1974 中央醫學 Vol.27 No.2

        The so called protease constitutes the principal parts of enzymotherapy and trypsin, chymotrypsin, streptokinase, plasmin, ?pronase-P, and bromelain are widely used. The basic activity of protease is to specifically split the molecular chain of protein. That is, it hydrolyzes abnormal proteins or from the clinical point of view, this may be described as (1) anti-inflammatory and anti-edematous activities, (2) necrotic tissue liquefying action, (3) anticoagulant activity, and (4) mucus liquefying activity. The direct mechanism of action of protease has been known to be a process whereby an oral protease in absorbed, binds with its inhibitor and the balance between plasmin-inhibitor and plasmin is destroyed, transiently producing such a state where plasmin is dominant, and this causes a therapeutic effect in one way or another. Danzen is a preparation of Serratio-peptidase, an anti-inflammatory oral enzyme, developed by the Research Laboratories of the Takeda Chemical Industries in Japan. It is more potent in anti-inflammatory activity and anti-tumefacient effect than heretofore available anti-inflammatory enzymes and has less side effect. We obtained the clinical experience of Danzen administered to 45 patients; inflammatory diseases 10 cases, swelling and hematoma after injury 8 cases, and postoperative swelling and hematoma 27 cases. The results are as follows: 1) Danzen was effective in reducing the induration of lesions; inflammatory lesion after 5 days of administration, traumatic lesion in 3 days and operative wound in 3 days. 2) Danzen was effective in decreasing the elevated skin temperature of lesions; 3 days after administration in all cases. 3) No particular toxicity or side effect of Danzen was seen, except for mild indigestion in 2 cases. 4) The effective rates were 80% in inflammatory diseases, 87. 5% in swelling and hematoma after injury, and 81. 5% in postoperative swelling and hematoma.

      • SCOPUSKCI등재

        냉수처치가 흰쥐의 화상조직에 미치는 영향

        마흥수,함기선,주상용,박경희,안용팔 大韓成形外科學會 1982 Archives of Plastic Surgery Vol.9 No.1

        Lewis(1930) & Langohr (1949) suggested that cold water therapy (CWT) reduces tissue metabolism, oxygen debt and dilates minute vessels, therefore increasing blood flow, on the burned tissue in rats. So this method diminishes tissue damage due to impaired circulation and may retard the development of infection. These experiments were performed to study the effects of CWT on the burned tissue in rats. Full thickness scald burns(‘80c’10sec)were inflicted on the backs of the 42 rats. Burned rats were divided into 2 groups: 27 rate as an experimental group (immediate and delayed CWT) and 15 rats as an untreated control. The untreated control was sacrificed on the 1/2th, 1st, 8th, 24th and 72th hour after burn. Immediate CWT group was immersed immediately into the cold water (1-2℃, 10min) after burn and sacrificed as same as the time of untreated control. Delayed CWT group was burned and CWT was performed after 5 min, 10min and 30 min delay. They were sacrificed on the 24th hour after burn. The specimens taken from all experimental animals were fixed in 10% neutral formalin embedded in paraffin wax, sectioned at a thickness of 5um, and stained with hematoxylineosin for general histologic findings. Observation was made of morphological changes in the collagen fibers, capillaries and separations between collagen fibers located in the skin of rats. The results were as follows: 1. The tissue injury of immediate CWT group was less severe than untreated control. 2. The more CWT is delayed, the more tissue injury is aggravated. So immediate CWT is the most effective modality in the CWT of bumed tissue.

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