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상황버섯 자실체로부터 분리된 수용성 다당류의 특성 분석 및 이의 베타 시크리타아제 활성 저해효과
조항수 ( Hang Soo Jo ),최두진 ( Doo Jin Choi ),정미자 ( Mi Ja Chung ),박제권 ( Jae Kweon Park ),박용일 ( Yong Ii Park ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4
알츠하이머병(Alzheimer`s disease, AD) 의 진행과정의 주요 분자는 베타아밀로이드 펩타이드(B-amyloid peptide, AB)이며, AB 생성에 가장 중요한 작용을 하는 효소가 B-secretase이다. 본 연구에서는 상황버섯 자실체로부터 수용성 고분자물을 분리, 정제하였고, 이들 고분자물이 주로 glucose, galactose, mannose 등으로 구성되어 있고, 특히, glucose 함량이 가장 많은 glucan의 일종으로서, FT-IR 구조분석, laminarinase 효소분석에 의한 결합구조 분석 등의 결과로부터, 최소한 일정 부분 beta-(1,3)-결합구조를 갖는 beta-glucans 들의 일종이고, beta-(1,6)-결합의 분지를 갖는 beta-(1,3)(1,6)-glucan은 아닌 beta-(1,3)-glucans 임을 확인하였다. Et-P는 분자량이 각각 1,629, 1,294, 21kDa인 다당류들로서, FT-IR 분석과 원소분석의 결과로 볼 때, Et-P가 페놀성(phenolic) 물질과 복합체 형태로 존재하는 다당류일 것으로 판단되었다. 상황버섯 자실체 열수 추출물로부터 분리된 수용성 다당류인 Et-P는 DPPH radical 소거능을 보이고, 특히, 뇌신경세포 사멸에 의한치매 유발 물질로 알려진 베타-아밀로이드 펩타이드(AB)를 생성하는 B-secretase 효소의 활성을 현저히 저해하는 효과를 나타냈다. 이는 상황버섯 자실체 유래 수용성 다당류인 Et-P가 향 후 보다 심도 깊은 연구를 통해 항치매 효과를 나타내는 건강 식의약소재로 개발될 가능성이 있음을 보였다. A key molecule in the pathogenesis of Alzheimer`s disease (AD) is the B-amyloid peptide (AB) generated by B-secretase activity, an aspartic protease. This study was designed to evaluate inhibitory effect of the highmolecular weight water-soluble polysaccharides (Et-P) isolated and purified from Phellinus linteus fruiting body on ß-secretase activity. The Et-P was purified from the hot water extract of Phellinus linteus fruiting body mainly by 75% ethanol precipitation and DEAE-Cellulose column chromatography. From the DEAE-Cellulose chromatogram and molecular weight analysis, the Et-P was shown to be a mixture of three polysaccharides with molecular mass of 1,629, 1,294, and 21 kDa, respectively. The monosaccharide composition of Et-P was determined to be glucose, galactose, and mannose as major sugars, glucose being the most prominent one (48% in mole percentage). The elemental analysis and FT-IR analysis suggested that Et-P is typical polysaccharides having at least partially B-linkages and possible existing as complex with phenolic compounds. The laminarinase digestion and HPAEC-PAD analysis suggested that Et-P is a variant of beta-(1,3)-glucans. The Et-P showed DPPH radical scavenging activity and, especially, a significant inhibitory activity on B-secreatase activity (48% inhibitin at 100ug/mL), suggesting that they may inhibit the formation of AB which is the major causative of Alzheimer`s disease. The results of this study suggest that the water soluble polysaccharides of Phellinus linteus fruiting body can be a potent material for the development of preventive or therapeutic agents for AD.
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영산강,섬진강수계 호소환경조사 -하동호 등 10개 호소 중심으로-
김신조 ( Shin Jo Kim ),송효정 ( Hyo Jeong Song ),박태진 ( Tae Jin Park ),황문영 ( Moon Young Hwang ),조항수 ( Hang Soo Cho ),송광덕 ( Kwang Duck Song ),이형진 ( Hyung Jin Lee ),김영석 ( Young Suk Kim ) 한국물환경학회 2015 한국물환경학회지 Vol.31 No.6
Yearly mean temperature in the 29 lakes surveyed ranges from 12.6 (Suncheon) to 13.9°C (Mokpo), the lowest in -2.7°C (January) and the highest in 25.9°C (July). Monthly mean the amount of rainfall recorded the highest of 336.7 mm in August and the lowest with 4.9 mm in January. A total of 424 species of phytoplankton were identified. They were 157 Chlorophyceae, 161 Bacillariophyceae, 39 Cyanophyceae, and 67 other algal taxa. The phytoplankton diversity were low in stream type reservoirs such as Guemho, Youngsan and Youngam. The population density of phytoplankton ranged from 19 to 53,161 cells/ml. Annual mean of total zooplankton abundance in 45 sites was 369±827 ind./L (n=180). Rotifers were the most common taxa and their relative abundance was high (65~77%). The benthic microinvertebrate fauna of 10 reservoirs of Jeonnam province were 71 species of 61 genera of 44 families of 16 orders of 7 classes of 4 phyla. Aquatic insects of Phylum Arthropoda were 50 species of 44 genera of 28 families of 6 orders. The number of individuals was 6,132. Diptera was highiest (41.3%), and Ephemeroptera (31.0%), Trichoptera (17.5%), Anellida (3.8%), Mollusca (3.3%), Crustacea (0.4%). Large hydrophytes were identified 32 taxa, 2 varieties 30 species 26 genera and 20 families. Especially, Jijung and Juam lakes require management such as physical remove of this ecosystem disturbance field plants. Fishes were identified total 44 taxa, such as 25 Cyprinidae (56.8%), 8 Cobitidae (17.0%), 3 Gobiidae (6.4%), 2 Bagridae (4.3%), 2 Osmeridae (4.3%), 2 Odontobutidae (4.3%), 2 Centrachidae (4.3%), 1 Siluridae (2.1%), and 1 Centropomidae (2.1%). A pale chub was dominant species (18.9%).
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