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유증상성 터어키안 내 지주막 낭종의 수술적 치험 -증례보고-
박동혁 ( Dong Hyuk Park ),정용구 ( Yong Gu Chung ),임동준 ( Dong Jun Lim ),조태형 ( Tai Hyeung Cho ) 대한뇌종양학회 2002 대한뇌종양학회지 Vol.1 No.2
We report the presentation and surgical management of one case with symptomatic intrasellar arachnoid cyst. A 37-year-old female presented with a 2-month history of headache. On neurological examination and preoperative hormonal evaluation, she had no abnormalities. The preoperative magnetic resonance images revealed a intrasellar mass which was hyperintense on T1-weighted image without enhancement after Gd-DTPA administration, and hypointense on T2-weighted image. She underwent transsphenoidal surgery. The cystic lesion was incised, and the colorless cystic fluid like CSF was drained without any solid portion. Postoperative course was uneventful. With regards to intraoperative findings, this lesion was diagnosed as arachnoid cyst.
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실험적 척수손상에 미치는 Nimodipine의 효과에 대한 연구
조태형,박윤관,정용구,정흥섭,서중근,이훈갑,이기찬,주정화 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.8-9
Nimodipine, the potent, centrally active, calcium channel blocker, is known to increase cerebral and spinal blood flow. In the present study, the authors investigated the effect on Nimodipine on injured spinal cord. The experiment was a randomized blind study in which four groups of five cats received Nimodipine(0.05㎎/㎏) intravenously. and control groups of five cats received only Diluent As a step in the investigation of the possible effect of spinal cord trauma on biochemical and ultrastructural changes in the injured cord, activities of lipid peroxidation were measured in the frozed-dried sample of the spinal cord and fine structure of the mylinated nerve fiber in the white matter were observed. An increase of lipid peroxidation level was found as early as 1 hour after the injury and the highest concentration was reached at 5 hours after the injury(P<0.01). Fine structures of the myelinated nerve fibers were changed progressively with the lapse of time after the injury. The effect of Nimodipine on lipid peroxidation and fine ultrastructural changes of myelinated nerve fibers were studied, and the result of this study revealed that Nimodipine groups showed a lower level of lipid peroxidation with statistical significance (P<0.05) and preservation of ultrastructural myelinated nerve fiber was prominent.
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