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      • 과량의 Vitamin A가 Rat 태자에 미치는 영향

        조순곤,김수일,곽명순,김원식 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

        For the study on the effects of vitamin A on the rat fetuses, 500mg/kg of retinol palmitate was administered orally once at the day 8.5 of gestation. In this study, the Sprague-Dawley rats were used as an experimental animal, which was divided into control and retinol palmitate treated groups. The animals were sacrificed under ether anesthesia at the day 12.5, 13.5, 14.5, 15.5 and 16.5 of gestation, laparotomized and hysterectomized. After counting the pregnant sacs, opened the sacs and removed the fetuses under stereoscopic observations, - fetal status, congenital malformations and other external anomalies etc.. The weight of live fetuses was measured and analysed it statistically, and compared the growth curves between 2 groups. The results were as follows ; 1. The survival rate of fetuses in the retinol palmitate treated group was lower significantly than that of control group except the day 12.5 of gestation. The rate was lowered daily from the day 12.5 to the day 16.5 of gestation. 2. The mean body weight of fetuses was lowered in the retinol palmitate treated group significantly from the day 12.5 to the day 16.5 of gestation, daily. 3. The congenital anomalies induced by retinol palmitate in this experiment were anencephaly, exencephaly and severe underdevelopment. According to the above results, it is considered that the retinol palmitate induces intrauterine fetal death caused by major congenital anomalies such as exencephaly and anencephaly, and delay the fetal growth by inhibition of differentiation and proliferation during organogenesis. But the exact mechanism of action cannot be known. And it is necessary to study the effects of retinol palmitate on the growth of fetuses with its congenital anomalies should be done with changing the dose, method of administration and the duration of treatment.

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