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오메가-3 불포화지방산이 노인여성의 심혈관 반응 및 노르에피네프린에 미치는 효과
한송이(Song Yi Han),김경희(Kyung Hee Kim),조등(Cao Teng),김종경(Jong Kyung Kim) 한국발육발달학회 2013 한국발육발달학회지 Vol.21 No.4
It is generally known that Omega-3 polyunsaturated fatty acids (n-3 PUFAs) supplementations decrease risks of sudden death and cardiovascular diseases. A previous study showed that n-3 PUFAs supplements improved stroke volume and peripheral vasoconstriction in the young. On the other hand, in the elderly, systolic blood pressure increases because of arterial stiffness produced by structural alterations of arterial wall occurring with aging. However, the effect of n-3 PUFAs has not been revealed in older humans. Therefore, the purpose of this study was to investigate the effects of hemodynamic responses with n-3 PUFAs supplement at rest and during exercise in elderly women. Subjects (>60 yrs) were divided into only n-3 group (OG), n-3+Placebo group (CG), and placebo group (PG). All subjects completed submaximal exercise testing for 5-7 minutes (60% VO2peak) before and after the nutritional supplementation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), stroke volume (SV) were continuously measured from rest through exercise. Blood samples were collected at rest and during exercise. There were no differences in HR and SBP at rest across groups. SBP was significantly decreased in OG (p<.05) and CG (p<.001) during exercise after the n-3 supplement. DBP and mean arterial pressure (MAP) were not significantly different at rest and during exercise across groups (p<.05). There were no differences in SV, cardiac output (CO), and total vascular conductance (TVC) at rest across groups. Both SV and CO were significantly decreased in PG (p<.05), and TVC were significantly decreased in PG (p<.05). Both SV and TVC tended to be increased during exercise in OG and CG. There was no difference in norepinephrine (NE) concentration at rest across groups, while NE tended to be decreased in OG and CG. These results suggest that n-3 PUFAs supplement could improve SV and blood flow to active skeletal muscle. Thus, n-3 PUFAs supplement may prevent hypertension and enhance exercise performance in elderly women.
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