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조낙준 대한피부과학회 1979 大韓皮膚科學會誌 Vol.17 No.1
55 patients which were clinically erythema multiforme and were diagnosed by punch biopsy, were studied clinically and histologically. The results obtained were as follows: 1. Erythema multiforme was more common in female than in male and they were most frequently occured in 3rd decade. 2. In most patients individuaIs had various type of skin lesions (macule, papuIe, bullous and iris) and the skin lesions were scattered on the various sites of thc body. 3. 30 patients out of 55 patients had seasonal variation, especially frequently occured in spring & autumn. 4. In the histopathological study while dermal disturbance was a predominant finding in the macular lesion, epidermal necrosis was seen high frequency in bullous & iris lesions. 5. The papillary edema showed in most cases, however 2 cases out of 55 lesions had not papillary edema. 6. The dermal inflammatory infiltrates were composed chiefly of lyrnpho-histiocytic and significant number of eosinophils were present in the inflammatory infiltrate in 27 % of the bullous lesions.
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재발성 아프타구내염에 대한 Levamisole 의 치료효과
손숙자,조낙준,최달용 대한피부과학회 1979 대한피부과학회지 Vol.17 No.6
There have been no standard treatments for recurrent aphthous stomatitis, and clinical management is usually directed toward symptomatic relief. Recent immunological investigations have focused on possible imrnunopathogenesis of the disease. Several reparters suggested that levamisole, nonspecific immune-stimulator, had a beneficiaI effect in controlling attacks of recurrent a,phthous stomatitis and in reducing subsequent episodes. The present study was undertaken to evaluate the therapeutic effectiveness of levamisole in patients with recurrent aphthous stomatitis. A total of 8 patients who had had recurrent aphthous stomatitis for 2 to 20 years and who had experienced at least one episode per month were selected for this study from the department of dermatology, National Medical Center, through March 1979 to September 1979, Levamisole (Decaris') was given 150mg, p.o., once daily on 3 consecutive days every week for 2 months. The results were as follows. 1) One patient had to have levamisole discontinued due to a high fever and exacerbations of tbe oral ulcerations. 2) 5 patients showed beneficial effects in reducing tbe number, frequency, pain and severity of recurrent aphthous stomatitis. 3) One patient showed no therapeutic response. 4) One patient, who has experienced new oral ulcerations continuously before starting levamisole, showed no recurrences of the lesions during the follow-up period of 3 months. 5) Side effects during levamisole administration were transient and generally mild, They included nausea, headache, dizziness and high fever.
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급성 발열성 호중구성 (好中球性) 피부병 ( Sweer 증후군 ) 의 2 예
신실,손숙자,조낙준,최달용 대한피부과학회 1980 大韓皮膚科學會誌 Vol.18 No.5
Acute febrile neutrophilic dermatosis, which was introduced to the dermatologic literature by Sweet in 1964, is characterized by persistent high fever and preceding upper respiratory infection like symptoms, polymorphonuclear leukocytosis in the peripheral blood, raised painful plaques on the limbs, face and neck, histologically a dense dermal infiltration with polymorphonuclear leukocyte, dramatic response to corticosteroids, and the absence of scarring. Case 1 was a 35 year-old female who had suffered from malaise, sore throat, and fever 3 to 7 days before the each episode of the cutaneous manifestation. Painful, red, raised, well-demarcated plaques appeared on the face with tendency of recurrences, and was accompanied by a few, small, shallow ulcerations on the lower Iip and tongue, and conjunctivitis. Polymorphonuclear leukocytosis (10400 with 65%, 11600 with 75%) and elevated ESR(23mm/hr, 19mm/hr) were found on two occasions. Histologically a dense inflammatory cell infiltration composed predominantly of polymorphonuclear neutrophils, small round cells, and a few eosinophils were seen in the dermis and subcutis, especially around the dermal capillaries. Alao there were many nuclear debris and marked endothelial cell proliferations. Case 2 was a 41 year-old housewife who experience mild fever and sore throat one week before the onset of cutaneous manifestations. Skin manifestations showed vesicular eruption on erythematous infiltrated base on neck and Rt. forearm, and erythematous tender subcoutaneous nodules, some of which coalesced to form erythematous plaque on the both pretivial regions. At that times, knee and ankle joint arthralgias were accompanied. Polymorphonuclear elukocytosis(11500 with 93%) and elevated ESR(105mm/hr) were found. Skin biopsy from vesiculopapular eruption on Rt. forearm showed acnathosis, spongiosis and exocytosis in the epidermis, and a dense inflammatory cell infiltration composed predominantly of PMNL and a few eosinophils in the dermis and subcutis. However, biopsy from the plaque lesion on lower leg showed mild perivascular inlammatory cell infiltration on the dermis and subcutis, chiefly of the lymphohistiocytic cells. And sweeling of the endothelial cells were found. The symtoms and signs of our cases were responded well to orally administered prednisolone.
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신실,김이중,조낙준 대한피부과학회 1978 대한피부과학회지 Vol.16 No.5
Pyogenic granuloma is not an uncommon oral cavity lesion and is a benign soft tissue tumor arising from the connective tissue of the skin or mucous membrane. We have reported a pedunculated tumor on the junctional area of the left side of upper lip and buccal mucosa which was developed without any history of trauma and clinically it was composed with condyloma acuminatum. Histopathological findings showed many newly formed blood vessels with marked endothelial swelling and collarette formation of rete ridges of epidermis. The lesion was completely subsided after surgical excision.
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