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RISS 인기검색어
- 검색키워드
- 저자 : 정택조 ( Taek Jo Jeong ) (검색결과 4 건)
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Sunitinib에 의해 발생한 수족증후군과 수포성 고정약진 1예
정택조 ( Taek Jo Jeong ),이은주 ( Eun Ju Lee ),정기헌 ( Ki Heon Jeong ),신민경 ( Min Kyung Shin ),김낙인 ( Nack In Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Sunitinib is multitargeted tyrosine kinase inhibitor, and this drug was approved for use to treat gastrointestinal stromal tumor and advanced renal cell carcinoma. It has also been shown to be efficacious in treating neuroendocrine, colon and breast cancer. Sunitinib therapy is often complicated by cutaneous adverse effects such as hand-foot syndrome, hair depigmentation, subungal splinter hemorrhage, xerosis, alopecia and seborrheic dermatitis-like reactions. But there have been no reports on patients presenting with a bullous fixed drug eruption associated with sunitinib administration. We report here on a case of a bullous fixed drug eruption and hand-foot syndrome, and these maladies were caused by this agent. (Korean J Dermatol 2009;47(6):739∼742)
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결절성 병변과 반피부위축증양 병변을 함께 보인 융기피부섬유육종
정택조 ( Taek Jo Jeong ),신민경 ( Min Kyung Shin ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Atrophic dermatofibrosarcoma protuberans (DFSP) is an uncommon clinical variant, which clinically mimics other atrophic dermatological conditions. Given the typical `protuberant` morphology of DFSP, such atrophic lesions may be difficult to diagnose clinically. We report a 44-year-old man who presented with an 8-month history of an asymptomatic, depressed, anetoderma-like plaque on the right subclavicular area. He also presented with a 1-year history of a 1.5×1.5 cm, asymptomatic, firm, erythematous nodule above an atrophic lesion. Biopsy specimens were taken from each lesion. These specimens, along with histochemical staining for CD34, established the diagnosis of dermatofibrosarcoma protuberans. (Korean J Dermatol 2009;47(3):361∼364)
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High Sensitivity C-reactive Protein을 이용하여 분석한 전신 염증과 단기간 저용량 Cyclosporine의 건선 치료효과의 상관관계
정택조 ( Taek Jo Jeong ),신민경 ( Min Kyung Shin ),김낙인 ( Nack In Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Background: Cyclosporine is an immunosuppressant that acts on T-cells and cytokines. Although the efficacy of systemic cyclosporine in the treatment of psoriasis has been established, the relationship between response to cyclosporine and systemic inflammation using the high sensitivity C-reactive protein (hs-CRP) immunoassay is still unclear. Objective: The aim of this study is to investigate whether systemic inflammation with clinical and laboratory findings indicate a response after 8 weeks of oral 3 mg/kg cyclosporine therapy in patients with psoriasis. Methods: Thirty-five patients with psoriasis were treated with oral cyclosporine for 8 weeks. The clinical response to oral cyclosporine was determined using the PASI score. The correlation between hs-CRP and the treatment response to cyclosporine was analyzed. Also, descriptive characteristics of psoriatic patients with psoriatic arthritis, metabolic syndrome, and high BMI (BMI≥25) were investigated. Results: Hs-CRP levels and PASI scores were significantly reduced after 8 weeks of oral cyclosporine treatment. Eight patients showed excellent response, fifteen a good response, and twelve a moderate response. The baseline hs-CRP levels in excellent and good response groups (1.35±0.59 mg/L and 1.32±0.86 mg/L, respectively) to oral cyclosporine were significantly higher than the moderate response group (0.51±0.20 mg/L, p=0.004). Psoriatic patients with psoriatic arthritis, metabolic syndrome, and high BMI demonstrated higher levels of baseline hs-CRP. Patients with psoriatic arthritis and metabolic syndrome showed greater response to cyclosporine treatment. Conclusion: Patients with greater inflammatory burden, as demonstrated by elevated baseline hs-CRP, have better treatment responses to cyclosporine compared to patients with lesser inflammation. (Korean J Dermatol 2010; 48(3):171~178)
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이은주 ( Eun Ju Lee ),오유진 ( Eu Jin Oh ),정택조 ( Taek Jo Jeong ),신민경 ( Min Kyung Shin ),김낙인 ( Nack In Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.9
Pyogenic granuloma (lobular capillary hemangioma) is a very common benign vascular lesion that frequently appears as a red to purple colored papule or polypoid mass. Any cutaneous or mucous membrane surface may be affected, they are rarely found intravascular or subcutaneous area. A 67-year-old female presented with a single, 0.5×0.5 cm sized movable subcutanous nodule on the right arm. A biopsy specimen showed multilobulated angiomatous nodule consisted of proliferative capillaries with fibrous septum in the subcutaneous layer. The tumor cells were positive for CD31, CD34, vimentin and smooth muscle actin. The lesion was excised and pyogenic granuloma was given as diagnosis by histopathological evaluation. The Subcutaneous type of pyogenic granuloma is rare but it should be part of the differential diagnosis of solitary nodule of extremities. (Korean J Dermatol 2010;48(9):776~779)
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