Repositioning of a mucolytic drug to a selective antibacterial against Vibrio cholerae

정인영,Bi-o Kim,Hye-Jeong Jang,You-Hee Cho 한국미생물학회 2020 The journal of microbiology Vol.58 No.1

Drug repositioning, the approach to explore existing drugs for use in new therapeutic indications, has emerged as an alternative drug development strategy. In this study, we found that a mucolytic drug, N-acetylcysteine (NAC) showed antibacterial activity against Vibrio cholerae. NAC can provide acid stress that selectively inhibited the growth of V. cholerae among other bacterial pathogens. To address the antibacterial mechanism of NAC against V. cholerae, six acr (acetylcysteine- resistant) mutants were isolated from 3,118 random transposon insertion clones. The transposon insertion sites of the six mutants were mapped at the five genes. All these mutants did not display NAC resistance under acidic conditions, despite their resistance to NAC under alkaline conditions, indicating that the NAC resistance directed by the acr mutations was independent of the unusual pH-sensitivity of V. cholerae. Furthermore, all these mutants displayed attenuated virulence and reduced biofilm formation, suggesting that the acr genes are required for pathogenesis of V. cholerae. This study validates the relevance of drug repositioning for antibacterials with new modes of action and will provide an insight into a novel antibacterial therapy for V. cholerae infections to minimize side effects and resistance emergence.

치료레이저각막절제술과 양막이식술의 동시 시행에 의한 잘쯔만결절변성의 치료효과

정인영,윤경철,In Young Jeong,Kyung Chul Yoon 대한안과학회 2006 대한안과학회지 Vol.47 No.6

투과체에 적용된 채광방식이 사무소공간의 색도 및 색온도분포에 미치는 영향 분석

정인영,김정태,Jeong, In-Young,Kim, Jeong-Tai 한국조명전기설비학회 2007 조명·전기설비학회논문지 Vol.21 No.3

투과체는 기본적으로 외부환경과 접촉할 수 있는 친화적이고 생태학적인 기능을 가지고 있으며, 이를 통해 유입되는 빛은 실내공간에 다양한 분위기를 연출할 수 있도록 해준다. 이에 본 연구는 투과체가 적용된 사무소건물을 대상으로 채광유입을 증대시킬 수 있는 채광방식을 설계하여 적용 시 실내의 색도와 색온도에 미치는 영향을 분석하였다. 이를 위하여 1/10축소모형을 제작하였으며, Prometric 1421이라는 측정기기를 이용하여 실험을 수행하였다. 측정결과 투과체가 갖는 파장대별 투과특성이 실내의 색도에 영향을 미치는 것으로 나타났으며, 빛의 유입을 증대시키는 채광방식을 설치할 경우 천정면의 색온도에 많은 영향을 주었으며, $5{\sim}20[%]$정도의 색온도를 증가시키는 것으로 나타났다. 따라서 채광시스템을 설치할 경우 활동적인 분의기의 공간이 연출될 수 있을 것으로 기대된다. One basic function of glazing system has always been the maintenance of visual contact with the natural environment-a fundamentally ecological function. In addition, penetration light through glazing system have an effect on variable atmosphere of interior. In this study, a typical office space was selected as a evaluation model and a 1/10 scale model was made. The conventional window, differentiated window and interior lightshelf were designed to enhance daylighting performance. The chromaticity and color temperature of interior space was measured using Prometric 1421. The result showed that transmittance by wavelength range of the glazing had an effect on chromaticity and color temperature. Also, color temperature of indoor environment were increased by $5{\sim}20[%]$ using differentiated window and interior lightshelf. Accordingly, it is thought that the use of a daylighting system will create activate indoor atmosphere.

부분 조절 내사시의 근거리각 기준 수술 후 장기간의 경과 관찰

정인영,박영걸,박상우,In Young Jeong,Yeoung Geol Park,Sang Woo Park 대한안과학회 2008 대한안과학회지 Vol.49 No.4

Purpose: To analyze the long-term outcome of near geared standard surgery with full hyperopic correction for partially accommodative esotropia. Methods: The medical records of a total of 24 patients with partially accommodative esotorpia, who had undergone bilateral or unilateral medial rectus recession were retrospectively reviewed. The amount of medial rectus recession was measured based on the near deviation after full hyperopic correction. During the follow-up period the changes of refractive error and angle of deviation were evaluated, and the titmus test and Worth 4-Dot test were performed. Results: The mean ages were 36.63±13.38 months (14~59 months) at the time of wearing glasses and 61.25±25.55 months (25~132 months) at the time of operation. The average follow-up period was 59.67±32.12 months (18~120 months) and preoperative refractive errors were +3.93±1.73 D sph and refractive errors at final visit were +3.64±2.07 D sph (p=0.53). The mean amount of esodeviation were 26.08±8.13PD and 4.25±6.63PD for pre- and post-operatively respectively. Nineteen patients showed postoperative deviation of 10PD or less, one patient was overcorrected, and four patients were undercorrected. Worth 4-Dot test resulted in a fusion response at near and far in one patient preoperatively and in 17 patients postoperatively (p=0.30). A titmus stereotest of less than 100 seconds of arc resulted in 1 of 7 patients and 6 of 14 patients at the time of preoperation and postoperation each (p=0.34). The results were not statistically significant. Four of ten high hyperopic patients (≥ +4.00 diopter) had under- or over-correction (p=0.12), though it was not statistically significant. There were no significant differences in combined conditions. Conclusions: Near geared standard surgery with full hyperopic correction in partially accommodative esotropia patients gave a good surgical result for patients in the mean follow-up duration of 59.67 months.

COLUMN - 축산관련 종사자 의무교육 내 가축 질병보호 '첫걸음'

정인영,Jeong, In-Yeong 한국오리협회 2016 오리마을 Vol.158 No.-

감염성 각막궤양에 의한 절박천공에서 구조 전층각막이식술의 효과

정인영,유인천,박영걸,윤경철,In-Young Jeong,In-Cheon You,Yeoung-Geol Park,PhD,Kyung Chul Yoon 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: To investigate the effect of tectonic penetrating keratoplasty for the treatment of impending perforations caused by infectious corneal ulcers. Methods: We analyzed preoperative and postoperative visual acuity, lesion location and size, graft size, postoperative outcome, and complications in 19 patients (19 eyes) with impending perforations due to infectious corneal ulcers. All patients underwent tectonic penetrating keratoplasty and had a minimum follow-up period of 6 months. Results: In our study, eight eyes (42.1%) had herpes simplex keratitis, 6 eyes (31.6%) had bacterial keratitis, and 5 eyes (26.3%) had fungal keratitis. Twelve eyes had a lesion located in the central cornea, while 7 eyes had a lesion located in the paracentral cornea. Visual acuity improved in 13 eyes (68.4%) and anatomical success was achieved in 16 eyes (84.2%). Three eyes (15.8%) developed a graft melting secondary to rejection. Complications included bullous keratopathy (3 eyes, 15.8%), graft infection (3 eyes, 15.8%), neovascularization (2 eyes, 10.5%), and secondary glaucoma (1 eye, 5.3%). Conclusions: Tectonic penetrating keratoplasty maintains ocular integrity and effectively treats impending perforations caused by infectious corneal ulcers.

각막이식술 후 재발한 단순포진바이러스 각막염에 대한 분석

정인영,이광훈,유인천,윤경철,In Young Jeong,MD,Kwang Hoon Lee,MD,In Cheon You,MD,PhD,Kyung Chul Yoon,MD,PhD 대한안과학회 2009 대한안과학회지 Vol.50 No.5

Purpose: To analyze the clinical aspects and risk factors for recurrent herpes simplex keratitis (HSK) after penetrating keratoplasty (PKP). Methods: Records from 78 eyes of 41 patients who underwent PKP for HSV keratitis with a mean follow-up duration of 31.83±21.35 months (24~97 months) were reviewed. The clinical aspects of recurrent keratitis, rejection, and survival rate were evaluated. Previous operation history, preoperative inflammation and neovascularization, graft size, suture methods, and antiviral use were analyzed to elucidate the risk factor for recurrent HSK after PKP. Results: HSK recurred in 47.4% of the patients at a mean time of 18.36±21.02 months after PKP. The mean duration of keratitis was 2.16±1.71 months and the mean frequency of recurrence was 1.41±0.69 times. Epithelial keratitis developed in 46.2% of the patients, and epithelial keratitis combined with stromal inflammation developed in 36.5%. Previous graft failure due to recurrent HSK and preoperative inflammation were significant risk factors for recurrent HSK after PKP (p=0.019, p=0.006). There were no statistically significant differences in graft rejection and survival rate between the two groups with and without recurrent HSK. Conclusions: The majority of cases of recurrent HSK after PKP were epithelial keratitis or epithelial keratitis combined with stromal inflammation, and risk factors for the recurrence of HSK were previous graft failure due to recurrent HSK and preoperative inflammation.

채광성능평가용 IEA 모니터링 프로토콜의 Mock-up모델 적용에 관한 연구

정인영(Jeong In Youmg),도진석(Do Jin Seok),김정태(Kim Jeong Tai) 한국태양에너지학회 2004 한국태양에너지학회 학술대회논문집 Vol.- No.-

가변 유리투과체로 구성된 실내공간의 채광성능평가

정인영(In Young Jeong),김정태(Jeong Tai Kim) 한국조명·전기설비학회 2004 한국조명·전기설비학회 학술대회논문집 Vol.2004 No.11월

본 연구는 우리나라 유리건축에서 적용되고 있는 유리투과체를 조사하여 투과율이 다른 4종류 즉, 투명유리, 색유리, 파스텔유리, 로이유리를 선정하여 복층유리로 제작하였다. 투과체에 따른 실내공간의 채광성능평가를 위하여 축소모형을 1/10으로 제작하였으며, 투과체의 구성을 일반형과 이중분할형으로 구성하여 기준실과 실험실에 설치하였다. 또한, 채광성능평가시 IEA모니터링 프로토콜을 적용하여 작업면, 벽면, 천정면에 대하여 조도를 외부조도와 동시에 측정하였고, 본 논문에서는 작업면에 대한 채광성능평가를 중심으로 분석하였다. 평가지표로서 주광조도비를 사용하였으며, 일반형과 이중분할형에 대한 가변 유리투과체를 변화시켰을 경우 투과율에 따른 실내공간의 채광성능을 평가하였다. 가변 유리투과체로 구성된 실내공간의 채광성능평가는 다음과 같이 분석되었다. 첫째, 실내공간에 일반형을 적용하여 서로 다른 투광성능을 가진 유리투과체가 적용된 경우 외부조도에 대한 내부조도 비율은 투과율이 증가할수록 일정하게 증가하는 것으로 나타났다. 이는 투과체가 갖는 투과성능의 영향으로 판단된다. 둘째, 일반형에 비해 이중분할형은 채광창으로 유입되는 채광학적 기여가 증가하여 실 전체의 조도를 증가시키며 특히, 실 중간부와 후면부의 경우 채광적 잠재력이 증대되어 실의 쾌적함과 시 환경적 질이 증대될 것으로 사료된다. 현재 유리건축물에 많이 적용되고 있는 저 투과체에 이중분할형을 적용할 경우 채광학적으로 많은 효과가 있을 것으로 기대된다.

채광시스템 유형별 실내공간의 시각적 쾌적성에 관한 평가

정인영(Jeong, In Young),최윤석(Choi, Yoon Seck),안현태(Ahn, Hyun Tae),김정태(Kim, Jeong Tai) 한국생태환경건축학회 2006 한국생태환경건축학회 논문집 Vol.6 No.1