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정윤노,박상규 한국데이터정보과학회 2008 한국데이터정보과학회지 Vol.19 No.4
Maximum likelihood estimator (MLE) and restricted maximum likelihood estimator (REMLE) approaches are available in analyzing the linear mixed model (LMM) like bioequivalence trials. US FDA (2001) guides that REMLE may be useful to assess bioequivalence (BE) test. This paper studies the statistical behaviors of the methods in assessing BE tests when some of observations are missing at random. The simulation results show that the REMLE maintains the given nominal level well and the MLE gives a bit higher power. Considering the levels and the powers, the REMLE approach is recommended when the sample sizes are small to moderate and the MLE approach should be used when the sample size is greater than 30.
박상규,남봉현,정윤노,이재영,정규진,Park, Sang-Gue,Nam, Bong-Hyun,Chung, Yun-Ro,Lee, Jae-Young,Jeong, Gyu-Jin 한국통계학회 2010 Communications for statistical applications and me Vol.17 No.1
제제간의 생물학적 동등성을 입증하는데 실패했을 때 추가시험을 허용하는 새로운 생물학적 동등성 시험 기준이 2008년 7월부터 시행하게 되었다. 추가시험의 의미나 시험 기준에서 제시하는 절차를 살펴보고 추가시험의 통계학적 의미를 고찰한다. 또한 사례를 통해 추가시험을 고려할 경우 어떤 점에 유의하여야 성공 할 수 있을 것인가 논의한다. The newly revised bioequivalence guideline of Korea allows the add-on test since July 1, 2008 and some discussion from statistical point of view would be needed for a practical use. The statistical model of add-on test is introduced and its two stage testing procedures are discussed. Meaningful statistical points of the add-on test are delivered through an illustrated example.
박동환,노명자,이아진,곽동욱,정윤노,김재홍 한국분자세포생물학회 2021 Molecules and cells Vol.44 No.12
BLT2 is a low-affinity receptor for leukotriene B4, a potent lipid mediator of inflammation generated from arachidonic acid via the 5-lipoxygenase pathway. The aim of this study was to investigate whether BLT2 plays any role in sepsis, a systemic inflammatory response syndrome caused by infection. A murine model of cecal ligation and puncture (CLP)-induced sepsis was used to evaluate the role of BLT2 in septic inflammation. In the present study, we observed that the levels of ligands for BLT2 (LTB4 [leukotriene B4] and 12(S)-HETE [12(S)-hydroxyeicosatetraenoic acid]) were significantly increased in the peritoneal lavage fluid and serum from mice with CLP-induced sepsis. We also observed that the levels of BLT2 as well as 5-LO and 12-LO, which are synthesizing enzymes for LTB4 and 12(S)-HETE, were significantly increased in lung and liver tissues in the CLP mouse model. Blockade of BLT2 markedly suppressed the production of sepsis-associated cytokines (IL-6 [interleukin-6], TNF-α [tumor necrosis factor alpha], and IL-1β [interleukin-1β] as well as IL-17 [interleukin-17]) and alleviated lung inflammation in the CLP group. Taken together, our results suggest that BLT2 cascade contributes to lung inflammation in CLP-induced sepsis by mediating the production of inflammatory cytokines. These findings suggest that BLT2 may be a potential therapeutic target for sepsis patients.